Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163451012> ?p ?o ?g. }
- W3163451012 abstract "Elicitation of broadly neutralizing antibodies (bnAbs) by an HIV vaccine will involve priming the immune system to activate antibody precursors, followed by boosting immunizations to select for antibodies with functional features required for neutralization breadth. The higher the number of acquired mutations necessary for function, the more convoluted are the antibody developmental pathways. HIV bnAbs acquire a large number of somatic mutations, but not all mutations are functionally important. Here we identified a minimal subset of mutations sufficient for the function of the naturally occurring V3-glycan bnAb DH270.6. Using antibody library screening, candidate envelope immunogens that interacted with DH270.6-like antibodies containing this set of key mutations were identified and selected in vitro. Our results demonstrate that less complex B cell evolutionary pathways than those naturally observed exist for the induction of HIV bnAbs by vaccination, and establish rational approaches to identify boosting sequential envelope candidate immunogens." @default.
- W3163451012 created "2021-05-24" @default.
- W3163451012 creator A5014301777 @default.
- W3163451012 creator A5017826715 @default.
- W3163451012 creator A5018055017 @default.
- W3163451012 creator A5029204805 @default.
- W3163451012 creator A5036586746 @default.
- W3163451012 creator A5041179950 @default.
- W3163451012 creator A5051827275 @default.
- W3163451012 creator A5051837710 @default.
- W3163451012 creator A5056331601 @default.
- W3163451012 creator A5057739482 @default.
- W3163451012 creator A5059261585 @default.
- W3163451012 creator A5072757239 @default.
- W3163451012 creator A5074729687 @default.
- W3163451012 creator A5084461087 @default.
- W3163451012 creator A5085482528 @default.
- W3163451012 date "2021-01-01" @default.
- W3163451012 modified "2023-10-16" @default.
- W3163451012 title "Rapid Selection of HIV Envelopes that Bind to Neutralizing Antibody B Cell Lineage Members with Functional Improbable Mutations" @default.
- W3163451012 cites W1534852475 @default.
- W3163451012 cites W1579246604 @default.
- W3163451012 cites W1969156908 @default.
- W3163451012 cites W1974431423 @default.
- W3163451012 cites W1978398372 @default.
- W3163451012 cites W1980696330 @default.
- W3163451012 cites W1980811933 @default.
- W3163451012 cites W1985145726 @default.
- W3163451012 cites W1993476635 @default.
- W3163451012 cites W2018295245 @default.
- W3163451012 cites W2055457867 @default.
- W3163451012 cites W2056710036 @default.
- W3163451012 cites W2059583074 @default.
- W3163451012 cites W2089766500 @default.
- W3163451012 cites W2093961711 @default.
- W3163451012 cites W2095706923 @default.
- W3163451012 cites W2107409328 @default.
- W3163451012 cites W2113236498 @default.
- W3163451012 cites W2116563764 @default.
- W3163451012 cites W2121096721 @default.
- W3163451012 cites W2134803208 @default.
- W3163451012 cites W2135151522 @default.
- W3163451012 cites W2146134187 @default.
- W3163451012 cites W2201713963 @default.
- W3163451012 cites W2281246504 @default.
- W3163451012 cites W2289942604 @default.
- W3163451012 cites W2464058430 @default.
- W3163451012 cites W2487638977 @default.
- W3163451012 cites W2514256437 @default.
- W3163451012 cites W2515557558 @default.
- W3163451012 cites W2515956381 @default.
- W3163451012 cites W2519123846 @default.
- W3163451012 cites W2520562417 @default.
- W3163451012 cites W2577540533 @default.
- W3163451012 cites W2582422151 @default.
- W3163451012 cites W2595317948 @default.
- W3163451012 cites W2597413779 @default.
- W3163451012 cites W2738428091 @default.
- W3163451012 cites W2780290167 @default.
- W3163451012 cites W2792079469 @default.
- W3163451012 cites W2794768685 @default.
- W3163451012 cites W2795237062 @default.
- W3163451012 cites W2804113494 @default.
- W3163451012 cites W2805330890 @default.
- W3163451012 cites W2811359070 @default.
- W3163451012 cites W2888011077 @default.
- W3163451012 cites W2890908940 @default.
- W3163451012 cites W2905369474 @default.
- W3163451012 cites W2939501350 @default.
- W3163451012 cites W2974273699 @default.
- W3163451012 cites W2982401945 @default.
- W3163451012 cites W2982412239 @default.
- W3163451012 cites W2993694092 @default.
- W3163451012 cites W2995806710 @default.
- W3163451012 cites W3010586097 @default.
- W3163451012 cites W4232674228 @default.
- W3163451012 doi "https://doi.org/10.2139/ssrn.3802020" @default.
- W3163451012 hasPublicationYear "2021" @default.
- W3163451012 type Work @default.
- W3163451012 sameAs 3163451012 @default.
- W3163451012 citedByCount "0" @default.
- W3163451012 crossrefType "journal-article" @default.
- W3163451012 hasAuthorship W3163451012A5014301777 @default.
- W3163451012 hasAuthorship W3163451012A5017826715 @default.
- W3163451012 hasAuthorship W3163451012A5018055017 @default.
- W3163451012 hasAuthorship W3163451012A5029204805 @default.
- W3163451012 hasAuthorship W3163451012A5036586746 @default.
- W3163451012 hasAuthorship W3163451012A5041179950 @default.
- W3163451012 hasAuthorship W3163451012A5051827275 @default.
- W3163451012 hasAuthorship W3163451012A5051837710 @default.
- W3163451012 hasAuthorship W3163451012A5056331601 @default.
- W3163451012 hasAuthorship W3163451012A5057739482 @default.
- W3163451012 hasAuthorship W3163451012A5059261585 @default.
- W3163451012 hasAuthorship W3163451012A5072757239 @default.
- W3163451012 hasAuthorship W3163451012A5074729687 @default.
- W3163451012 hasAuthorship W3163451012A5084461087 @default.
- W3163451012 hasAuthorship W3163451012A5085482528 @default.
- W3163451012 hasBestOaLocation W31634510122 @default.
- W3163451012 hasConcept C104317684 @default.
- W3163451012 hasConcept C154945302 @default.