Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163485201> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3163485201 endingPage "889" @default.
- W3163485201 startingPage "875" @default.
- W3163485201 abstract "Aim: Ivosidenib is a potent and selective small molecule inhibitor of mutant isocitrate dehydrogenase 1. Accurate measurement of ivosidenib is the key to ivosidenib pharmacokinetics in clinical trials. Materials & methods: Quantitation of ivosidenib was conducted by using a stable isotope labeled compound (ivosidenib-d4) as the internal standard. Results: This assay was validated and successfully applied to support multiple clinical trials. Selected clinical samples were also tested by a chiral LC-MS/MS method against four ivosidenib isomer standards to exclude the possibility of in vivo racemization of ivosidenib. Conclusion: A robust LC-MS/MS method was validated for ivosidenib in human plasma. This is the first time for ivosidenib bioanalytical method in any human matrix to be reported." @default.
- W3163485201 created "2021-05-24" @default.
- W3163485201 creator A5020946252 @default.
- W3163485201 creator A5045410576 @default.
- W3163485201 creator A5051710730 @default.
- W3163485201 creator A5086035022 @default.
- W3163485201 creator A5087284633 @default.
- W3163485201 creator A5090731919 @default.
- W3163485201 date "2021-06-01" @default.
- W3163485201 modified "2023-10-13" @default.
- W3163485201 title "Quantitation of ivosidenib in human plasma via LC–MS/MS and its application in clinical trials" @default.
- W3163485201 cites W2002134084 @default.
- W3163485201 cites W2008777301 @default.
- W3163485201 cites W2014602198 @default.
- W3163485201 cites W2080452140 @default.
- W3163485201 cites W2094851085 @default.
- W3163485201 cites W2123385055 @default.
- W3163485201 cites W2131860315 @default.
- W3163485201 cites W2154313451 @default.
- W3163485201 cites W2551053117 @default.
- W3163485201 cites W2906252871 @default.
- W3163485201 cites W2918744718 @default.
- W3163485201 cites W2919003988 @default.
- W3163485201 cites W2942027709 @default.
- W3163485201 cites W2946454907 @default.
- W3163485201 cites W2983161553 @default.
- W3163485201 cites W2984052840 @default.
- W3163485201 cites W3017271793 @default.
- W3163485201 cites W3047460744 @default.
- W3163485201 doi "https://doi.org/10.4155/bio-2021-0034" @default.
- W3163485201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33998826" @default.
- W3163485201 hasPublicationYear "2021" @default.
- W3163485201 type Work @default.
- W3163485201 sameAs 3163485201 @default.
- W3163485201 citedByCount "6" @default.
- W3163485201 countsByYear W31634852012023 @default.
- W3163485201 crossrefType "journal-article" @default.
- W3163485201 hasAuthorship W3163485201A5020946252 @default.
- W3163485201 hasAuthorship W3163485201A5045410576 @default.
- W3163485201 hasAuthorship W3163485201A5051710730 @default.
- W3163485201 hasAuthorship W3163485201A5086035022 @default.
- W3163485201 hasAuthorship W3163485201A5087284633 @default.
- W3163485201 hasAuthorship W3163485201A5090731919 @default.
- W3163485201 hasConcept C185592680 @default.
- W3163485201 hasConcept C43617362 @default.
- W3163485201 hasConceptScore W3163485201C185592680 @default.
- W3163485201 hasConceptScore W3163485201C43617362 @default.
- W3163485201 hasIssue "11" @default.
- W3163485201 hasLocation W31634852011 @default.
- W3163485201 hasLocation W31634852012 @default.
- W3163485201 hasOpenAccess W3163485201 @default.
- W3163485201 hasPrimaryLocation W31634852011 @default.
- W3163485201 hasRelatedWork W1531601525 @default.
- W3163485201 hasRelatedWork W2319480705 @default.
- W3163485201 hasRelatedWork W2384464875 @default.
- W3163485201 hasRelatedWork W2606230654 @default.
- W3163485201 hasRelatedWork W2607424097 @default.
- W3163485201 hasRelatedWork W2748952813 @default.
- W3163485201 hasRelatedWork W2899084033 @default.
- W3163485201 hasRelatedWork W2948807893 @default.
- W3163485201 hasRelatedWork W4387497383 @default.
- W3163485201 hasRelatedWork W2778153218 @default.
- W3163485201 hasVolume "13" @default.
- W3163485201 isParatext "false" @default.
- W3163485201 isRetracted "false" @default.
- W3163485201 magId "3163485201" @default.
- W3163485201 workType "article" @default.