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- W3163492759 abstract "Pseudopeptide analogs that feature acyl group, reduced-bond, and/or stable chemical-construct replacements for amino acids or peptide linkages mimic the biological activity of the insect kinin, sulfakinin, and myosuppressin peptide families. The non-peptide mimetic CP-96,345-1 demonstrated both agonism and antagonism of the cockroach hindgut myostimulatory activity of substance P, which shows sequence homology with the insect locustatachykinins. Biological evaluation of a rigid cyclic analog reveals the conformational preference of the pyrokinin/PBAN active-core during interaction with hindgut/oviduct contractile and pheromone production receptors. The importance of information on the conformational requirements for neuropeptide activity for the development of peptidomimetics is also discussed." @default.
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- W3163492759 date "1993-12-20" @default.
- W3163492759 modified "2023-09-27" @default.
- W3163492759 title "Pseudopeptide Mimetic Analogs of Insect Neuropeptides" @default.
- W3163492759 doi "https://doi.org/10.1021/bk-1994-0551.ch015" @default.
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