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- W3163518006 abstract "The mechanisms by which the nuclear lamina of tumor cells influences tumor growth and migration are highly disputed. Lamin A and its variant lamin C are key lamina proteins that control nucleus stiffness and chromatin conformation. Downregulation of lamin A/C in two prototypic metastatic lines, B16F10 melanoma and E0771 breast carcinoma, facilitated cell squeezing through rigid pores, and reduced heterochromatin content. Surprisingly, both lamin A/C knockdown cells grew poorly in 3D spheroids within soft agar, and lamin A/C deficient cells derived from spheroids transcribed lower levels of the growth regulator Yap1. Unexpectedly, the transendothelial migration of both cancer cells in vitro and in vivo, through lung capillaries, was not elevated by lamin A/C knockdown and their metastasis in lungs was even dramatically reduced. Our results are the first indication that reduced lamin A/C content in distinct types of highly metastatic cancer cells does not elevate their transendothelial migration (TEM) capacity and diapedesis through lung vessels but can compromise lung metastasis at a post extravasation level." @default.
- W3163518006 created "2021-05-24" @default.
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- W3163518006 date "2021-05-14" @default.
- W3163518006 modified "2023-10-12" @default.
- W3163518006 title "Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis" @default.
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- W3163518006 cites W1996795546 @default.
- W3163518006 cites W2001971523 @default.
- W3163518006 cites W2002479625 @default.
- W3163518006 cites W2004268823 @default.
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- W3163518006 cites W2025710957 @default.
- W3163518006 cites W2028399621 @default.
- W3163518006 cites W2030637965 @default.
- W3163518006 cites W2035838778 @default.
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- W3163518006 cites W2116269551 @default.
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- W3163518006 cites W2179438025 @default.
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- W3163518006 cites W2754007808 @default.
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- W3163518006 doi "https://doi.org/10.3390/cancers13102383" @default.
- W3163518006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8157058" @default.
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