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- W316353930 abstract "Objective To investigate inhibitory effect of Artmeter (Artm)on brain glioma angiogenesis in SD rat.Methods MTT (Methy thiazolyl tetrazolium) assay was used to evaluate the inhibitory effect of Artemether treatment on C6 glioma cells. Forty (20 male and 20 female) SD rats which was subcutaneous implantation with SD rat C6 glioma cell (1×106/μl) in cerebral cortex were divided into 5 grouTP randomly,each group had 8 rats.All were taken orally.After 3 day of implantation the treatment was started and continued until 10th day,and the rat killed 20th day. Whole brain was fixed and length-path (a mm) and short-path (b mm) of tumors were measured. Volume of tumor was calculated following formula:V (mm3) = a2bπ∕6. Micro-vascular dense (MVD) was observed under the microscopy by immunohistochemistry.Results The value of Micro-vascular dense in different therapy grouTP was groupⅠ(39±4),group Ⅱ(29±6),group Ⅲ (12±8)and group Ⅳ(10±5),normal saline control group is (52±7),respectively,Micro-vascular dense (MVD) in different therapy grouTP was significant lower than that in control group (P0.05,P0.01 respectively) and volume of brain glioma in different therapy grouTP is significant smaller than that in control group (P0.05,P0.01 respectively).Conclusion There is significant inhibitory effect of Artmeter on brain glioma angiogenesis in SD rat in some arrange dosage. The mechanism that Artemether inhibits brain glioma growth and metastasis may be penetrating the blood-brain barrier by inhibiting angiogenesis." @default.
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- W316353930 date "2009-01-01" @default.
- W316353930 modified "2023-09-24" @default.
- W316353930 title "Inhibitive effect of artemether on brain glioma angiogenesis in SD rat." @default.
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