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• W3163662136 endingPage "e1009606" @default.
• W3163662136 startingPage "e1009606" @default.
• W3163662136 abstract "The emergence of new pathogens is a major threat to public and veterinary health. Changes in bacterial habitat such as a switch in host or disease tropism are typically accompanied by genetic diversification. Staphylococcus aureus is a multi-host bacterial species associated with human and livestock infections. A microaerophilic subspecies, Staphylococcus aureus subsp. anaerobius, is responsible for Morel's disease, a lymphadenitis restricted to sheep and goats. However, the evolutionary history of S. aureus subsp. anaerobius and its relatedness to S. aureus are unknown. Population genomic analyses of clinical S. aureus subsp. anaerobius isolates revealed a highly conserved clone that descended from a S. aureus progenitor about 1000 years ago before differentiating into distinct lineages that contain African and European isolates. S. aureus subsp. anaerobius has undergone limited clonal expansion, with a restricted population size, and an evolutionary rate 10-fold slower than S. aureus. The transition to its current restricted ecological niche involved acquisition of a pathogenicity island encoding a ruminant host-specific effector of abscess formation, large chromosomal re-arrangements, and the accumulation of at least 205 pseudogenes, resulting in a highly fastidious metabolism. Importantly, expansion of ~87 insertion sequences (IS) located largely in intergenic regions provided distinct mechanisms for the control of expression of flanking genes, including a novel mechanism associated with IS-mediated anti-anti-sense decoupling of ancestral gene repression. Our findings reveal the remarkable evolutionary trajectory of a host-restricted bacterial pathogen that resulted from extensive remodelling of the S. aureus genome through an array of diverse mechanisms in parallel." @default.
• W3163662136 created "2021-05-24" @default.
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• W3163662136 date "2021-05-20" @default.
• W3163662136 modified "2023-10-16" @default.
• W3163662136 title "Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen" @default.
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• W3163662136 doi "https://doi.org/10.1371/journal.ppat.1009606" @default.
• W3163662136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8171923" @default.
• W3163662136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34015034" @default.
• W3163662136 hasPublicationYear "2021" @default.
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