FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163722171> ?p ?o ?g. }

• W3163722171 endingPage "250" @default.
• W3163722171 startingPage "231" @default.
• W3163722171 abstract "<b><i>Background:</i></b> Corticotropin-releasing hormone (CRH) mediates physiological responses to stressors in mammals by triggering pituitary secretion of adrenocorticotropic hormone, which stimulates adrenal release of cortisol. CRH belongs to a family of related neuropeptides that include sauvagine, urotensin-I, and urocortins in vertebrates and the diuretic hormone DH44 in insects, indicating that the evolutionary origin of this neuropeptide family can be traced to the common ancestor of the Bilateria. However, little is known about CRH-type neuropeptides in deuterostome invertebrates. <b><i>Methods:</i></b> Here, we used mass spectrometry, mRNA in situ hybridization, and immunohistochemistry to investigate the structure and expression of a CRH-type neuropeptide (ArCRH) in the starfish <i>Asterias rubens</i> (phylum Echinodermata). <b><i>Results:</i></b> ArCRH is a 40-residue peptide with N-terminal pyroglutamylation and C-terminal amidation, and it has a widespread pattern of expression in <i>A. rubens</i>. In the central nervous system comprising the circumoral nerve ring and 5 radial nerve cords, ArCRH-expressing cells and fibres were revealed in both the ectoneural region and the hyponeural region, which contains the cell bodies of motoneurons. Accordingly, ArCRH immunoreactivity was detected in innervation of the ampulla and podium of locomotory organs (tube feet), and ArCRH is the first neuropeptide to be identified as a marker for nerve fibres located in the muscle layer of these organs. ArCRH immunoreactivity was also revealed in protractile organs that mediate gas exchange (papulae), the apical muscle, and the digestive system. <b><i>Conclusions:</i></b> Our findings provide the first insights into CRH-type neuropeptide expression and function in the unique context of the pentaradially symmetrical body plan of an echinoderm." @default.
• W3163722171 created "2021-05-24" @default.
• W3163722171 creator A5022475813 @default.
• W3163722171 creator A5039453346 @default.
• W3163722171 creator A5040614063 @default.
• W3163722171 creator A5071431269 @default.
• W3163722171 creator A5074477203 @default.
• W3163722171 date "2021-05-07" @default.
• W3163722171 modified "2023-10-17" @default.
• W3163722171 title "Molecular Identification and Cellular Localization of a Corticotropin-Releasing Hormone-Type Neuropeptide in an Echinoderm" @default.
• W3163722171 cites W1493629431 @default.
• W3163722171 cites W1531005638 @default.
• W3163722171 cites W1534986377 @default.
• W3163722171 cites W1580426270 @default.
• W3163722171 cites W1968446099 @default.
• W3163722171 cites W1972140586 @default.
• W3163722171 cites W1972482480 @default.
• W3163722171 cites W1978821174 @default.
• W3163722171 cites W1992338483 @default.
• W3163722171 cites W1994011041 @default.
• W3163722171 cites W2015865718 @default.
• W3163722171 cites W2016403923 @default.
• W3163722171 cites W2017168736 @default.
• W3163722171 cites W2020003088 @default.
• W3163722171 cites W2028587575 @default.
• W3163722171 cites W2028710649 @default.
• W3163722171 cites W2040131498 @default.
• W3163722171 cites W2049544574 @default.
• W3163722171 cites W2052530157 @default.
• W3163722171 cites W2068818952 @default.
• W3163722171 cites W2070813582 @default.
• W3163722171 cites W2082979723 @default.
• W3163722171 cites W2090329295 @default.
• W3163722171 cites W2091345848 @default.
• W3163722171 cites W2092951387 @default.
• W3163722171 cites W2095036452 @default.
• W3163722171 cites W2095646540 @default.
• W3163722171 cites W2119990334 @default.
• W3163722171 cites W2120123737 @default.
• W3163722171 cites W2133260119 @default.
• W3163722171 cites W2153327500 @default.
• W3163722171 cites W2166293213 @default.
• W3163722171 cites W2181621432 @default.
• W3163722171 cites W2284531539 @default.
• W3163722171 cites W2290000470 @default.
• W3163722171 cites W2304774801 @default.
• W3163722171 cites W2305782648 @default.
• W3163722171 cites W2398850086 @default.
• W3163722171 cites W2462151648 @default.
• W3163722171 cites W2547762298 @default.
• W3163722171 cites W2559112499 @default.
• W3163722171 cites W2607412291 @default.
• W3163722171 cites W2625671288 @default.
• W3163722171 cites W2730788898 @default.
• W3163722171 cites W2747308049 @default.
• W3163722171 cites W2753719784 @default.
• W3163722171 cites W2759114757 @default.
• W3163722171 cites W2774361525 @default.
• W3163722171 cites W2787755244 @default.
• W3163722171 cites W2807506564 @default.
• W3163722171 cites W2886295955 @default.
• W3163722171 cites W2889565365 @default.
• W3163722171 cites W2889854149 @default.
• W3163722171 cites W2921687230 @default.
• W3163722171 cites W2950404890 @default.
• W3163722171 cites W2964463082 @default.
• W3163722171 cites W3084081140 @default.
• W3163722171 cites W4376848280 @default.
• W3163722171 doi "https://doi.org/10.1159/000517087" @default.
• W3163722171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33965952" @default.
• W3163722171 hasPublicationYear "2021" @default.
• W3163722171 type Work @default.
• W3163722171 sameAs 3163722171 @default.
• W3163722171 citedByCount "5" @default.
• W3163722171 countsByYear W31637221712022 @default.
• W3163722171 countsByYear W31637221712023 @default.
• W3163722171 crossrefType "journal-article" @default.
• W3163722171 hasAuthorship W3163722171A5022475813 @default.
• W3163722171 hasAuthorship W3163722171A5039453346 @default.
• W3163722171 hasAuthorship W3163722171A5040614063 @default.
• W3163722171 hasAuthorship W3163722171A5071431269 @default.
• W3163722171 hasAuthorship W3163722171A5074477203 @default.
• W3163722171 hasBestOaLocation W31637221711 @default.
• W3163722171 hasConcept C104317684 @default.
• W3163722171 hasConcept C118303440 @default.
• W3163722171 hasConcept C126322002 @default.
• W3163722171 hasConcept C134018914 @default.
• W3163722171 hasConcept C150194340 @default.
• W3163722171 hasConcept C151730666 @default.
• W3163722171 hasConcept C170493617 @default.
• W3163722171 hasConcept C18903297 @default.
• W3163722171 hasConcept C2777929075 @default.
• W3163722171 hasConcept C2778175403 @default.
• W3163722171 hasConcept C2778458438 @default.
• W3163722171 hasConcept C2778534911 @default.
• W3163722171 hasConcept C2778961482 @default.
• W3163722171 hasConcept C2780546910 @default.
• W3163722171 hasConcept C54355233 @default.

• next