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- W3163733787 abstract "In female mammals, meiotic prophase one begins during fetal development. Oocytes transition through the prophase one substages consisting of leptotene, zygotene, and pachytene, and are finally arrested at the diplotene substage, for months in mice and years in humans. After puberty, luteinizing hormone induces ovulation and meiotic resumption in a cohort of oocytes, driving the progression from meiotic prophase one to metaphase two. If fertilization occurs, the oocyte completes meiosis two followed by fusion with the sperm nucleus and preparation for zygotic divisions; otherwise, it is passed into the uterus and degenerates. Specifically in the mouse, oocytes enter meiosis at 13.5 days post coitum. As meiotic prophase one proceeds, chromosomes find their homologous partner, synapse, exchange genetic material between homologs and then begin to separate, remaining connected at recombination sites. At postnatal day 5, most of the oocytes have reached the late diplotene (or dictyate) substage of prophase one where they remain arrested until ovulation. This review focuses on events and mechanisms controlling the progression through meiotic prophase one, which include recombination, synapsis and control by signaling pathways. These events are prerequisites for proper chromosome segregation in meiotic divisions; and if they go awry, chromosomes mis-segregate resulting in aneuploidy. Therefore, elucidating the mechanisms regulating meiotic progression is important to provide a foundation for developing improved treatments of female infertility." @default.
- W3163733787 created "2021-05-24" @default.
- W3163733787 creator A5015537905 @default.
- W3163733787 creator A5077399002 @default.
- W3163733787 date "2021-05-20" @default.
- W3163733787 modified "2023-10-18" @default.
- W3163733787 title "Regulation of Meiotic Prophase One in Mammalian Oocytes" @default.
- W3163733787 cites W1510396537 @default.
- W3163733787 cites W1529934215 @default.
- W3163733787 cites W1639816383 @default.
- W3163733787 cites W1851148382 @default.
- W3163733787 cites W1963766206 @default.
- W3163733787 cites W1963998725 @default.
- W3163733787 cites W1969901238 @default.
- W3163733787 cites W1974717740 @default.
- W3163733787 cites W1978834783 @default.
- W3163733787 cites W1979291624 @default.
- W3163733787 cites W1981372238 @default.
- W3163733787 cites W1983844625 @default.
- W3163733787 cites W1986800638 @default.
- W3163733787 cites W1987995349 @default.
- W3163733787 cites W1990699200 @default.
- W3163733787 cites W1990850819 @default.
- W3163733787 cites W1994831927 @default.
- W3163733787 cites W1999301366 @default.
- W3163733787 cites W2002557721 @default.
- W3163733787 cites W2006059948 @default.
- W3163733787 cites W2006319417 @default.
- W3163733787 cites W2013313016 @default.
- W3163733787 cites W2013881895 @default.
- W3163733787 cites W2014988420 @default.
- W3163733787 cites W2016162945 @default.
- W3163733787 cites W2016464119 @default.
- W3163733787 cites W2024459631 @default.
- W3163733787 cites W2024629052 @default.
- W3163733787 cites W2027226662 @default.
- W3163733787 cites W2028597364 @default.
- W3163733787 cites W2028697124 @default.
- W3163733787 cites W2031743305 @default.
- W3163733787 cites W2032492109 @default.
- W3163733787 cites W2036459341 @default.
- W3163733787 cites W2036654302 @default.
- W3163733787 cites W2041002646 @default.
- W3163733787 cites W2042063022 @default.
- W3163733787 cites W2043396979 @default.
- W3163733787 cites W2043846400 @default.
- W3163733787 cites W2044994347 @default.
- W3163733787 cites W2046951954 @default.
- W3163733787 cites W2047657819 @default.
- W3163733787 cites W2050395183 @default.
- W3163733787 cites W2054305990 @default.
- W3163733787 cites W2054496326 @default.
- W3163733787 cites W2057310660 @default.
- W3163733787 cites W2057965747 @default.
- W3163733787 cites W2059204632 @default.
- W3163733787 cites W2059702765 @default.
- W3163733787 cites W2059821529 @default.
- W3163733787 cites W2061776278 @default.
- W3163733787 cites W2063292930 @default.
- W3163733787 cites W2064525704 @default.
- W3163733787 cites W2067135122 @default.
- W3163733787 cites W2067305429 @default.
- W3163733787 cites W2070744469 @default.
- W3163733787 cites W2071040218 @default.
- W3163733787 cites W2072401812 @default.
- W3163733787 cites W2080484525 @default.
- W3163733787 cites W2085188271 @default.
- W3163733787 cites W2093926676 @default.
- W3163733787 cites W2096413852 @default.
- W3163733787 cites W2097072453 @default.
- W3163733787 cites W2097891387 @default.
- W3163733787 cites W2099448734 @default.
- W3163733787 cites W2100876394 @default.
- W3163733787 cites W2101650794 @default.
- W3163733787 cites W2103553300 @default.
- W3163733787 cites W2104756642 @default.
- W3163733787 cites W2111131079 @default.
- W3163733787 cites W2111145503 @default.
- W3163733787 cites W2117082199 @default.
- W3163733787 cites W2121312894 @default.
- W3163733787 cites W2123283684 @default.
- W3163733787 cites W2130388722 @default.
- W3163733787 cites W2134710117 @default.
- W3163733787 cites W2136275081 @default.
- W3163733787 cites W2138919235 @default.
- W3163733787 cites W2139697025 @default.
- W3163733787 cites W2140164632 @default.
- W3163733787 cites W2140915850 @default.
- W3163733787 cites W2141757729 @default.
- W3163733787 cites W2143526409 @default.
- W3163733787 cites W2144089726 @default.
- W3163733787 cites W2146522923 @default.
- W3163733787 cites W2150490516 @default.
- W3163733787 cites W2150599578 @default.
- W3163733787 cites W2153820061 @default.
- W3163733787 cites W2156632388 @default.
- W3163733787 cites W2161758325 @default.
- W3163733787 cites W2171960324 @default.
- W3163733787 cites W2209015452 @default.
- W3163733787 cites W2213937301 @default.