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- W3163753886 endingPage "5240" @default.
- W3163753886 startingPage "5240" @default.
- W3163753886 abstract "Adenoviruses are large (~950 Å) and complex non-enveloped, dsDNA icosahedral viruses. They have a pseudo-T = 25 triangulation number with at least 12 different proteins composing the virion. These include the major and minor capsid proteins, core proteins, maturation protease, terminal protein, and packaging machinery. Although adenoviruses have been studied for more than 60 years, deciphering their architecture has presented a challenge for structural biology techniques. An outstanding event was the first near-atomic resolution structure of human adenovirus type 5 (HAdV-C5), solved by cryo-electron microscopy (cryo-EM) in 2010. Discovery of new adenovirus types, together with methodological advances in structural biology techniques, in particular cryo-EM, has lately produced a considerable amount of new, high-resolution data on the organization of adenoviruses belonging to different species. In spite of these advances, the organization of the non-icosahedral core is still a great unknown. Nevertheless, alternative techniques such as atomic force microscopy (AFM) are providing interesting glimpses on the role of the core proteins in genome condensation and virion stability. Here we summarize the current knowledge on adenovirus structure, with an emphasis on high-resolution structures obtained since 2010." @default.
- W3163753886 created "2021-05-24" @default.
- W3163753886 creator A5017884647 @default.
- W3163753886 creator A5019301968 @default.
- W3163753886 creator A5043820913 @default.
- W3163753886 creator A5074341928 @default.
- W3163753886 date "2021-05-15" @default.
- W3163753886 modified "2023-10-16" @default.
- W3163753886 title "Adenovirus Structure: What Is New?" @default.
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