FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163812047> ?p ?o ?g. }

• W3163812047 endingPage "107458" @default.
• W3163812047 startingPage "107458" @default.
• W3163812047 abstract "Considerable work indicates that instrumental responding is context-dependent, but the neural mechanisms underlying this phenomenon are poorly understood. Given the important role for the hippocampal formation in contextual processing, we hypothesized that reversible inactivation of the hippocampus would impair the context-dependence of active avoidance. To test this hypothesis, we used a two-way signaled active avoidance (SAA) task that requires rats to shuttle across a divided chamber during a tone CS in order to avoid a footshock US. After training, avoidance responding was assessed in an extinction test in both the training context and a novel context in a counterbalanced order. Rats performed significantly more avoidance responses in the training context than in the novel context, demonstrating the context-dependence of shuttle avoidance behavior. To examine the role of the hippocampus in the context-dependence of SAA, we reversibly inactivated either the dorsal (DH) or ventral hippocampus (VH) prior to testing. Inactivation of the VH eliminated the context-dependence of SAA and elevated avoidance responding in the novel context to levels similar to that expressed in the training context. In contrast, DH inactivation had no effect on avoidance in either context, and neither manipulation affected freezing behavior. Therefore, the integrity of the VH, but not DH, is required for the expression of the context-dependence of avoidance behavior." @default.
• W3163812047 created "2021-05-24" @default.
• W3163812047 creator A5029845153 @default.
• W3163812047 creator A5034789487 @default.
• W3163812047 creator A5037894723 @default.
• W3163812047 creator A5039619508 @default.
• W3163812047 creator A5042942785 @default.
• W3163812047 creator A5053569878 @default.
• W3163812047 date "2021-09-01" @default.
• W3163812047 modified "2023-09-29" @default.
• W3163812047 title "Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats" @default.
• W3163812047 cites W1921383166 @default.
• W3163812047 cites W1963854355 @default.
• W3163812047 cites W1964240411 @default.
• W3163812047 cites W1984624029 @default.
• W3163812047 cites W1997097282 @default.
• W3163812047 cites W2001417852 @default.
• W3163812047 cites W2003973418 @default.
• W3163812047 cites W2006664398 @default.
• W3163812047 cites W2006878506 @default.
• W3163812047 cites W2010947503 @default.
• W3163812047 cites W2012859237 @default.
• W3163812047 cites W2013413808 @default.
• W3163812047 cites W2019793714 @default.
• W3163812047 cites W2037877714 @default.
• W3163812047 cites W2043534501 @default.
• W3163812047 cites W2049549817 @default.
• W3163812047 cites W2051005796 @default.
• W3163812047 cites W2052329772 @default.
• W3163812047 cites W2053486952 @default.
• W3163812047 cites W2059354993 @default.
• W3163812047 cites W2060761472 @default.
• W3163812047 cites W2072240577 @default.
• W3163812047 cites W2082070038 @default.
• W3163812047 cites W2086721550 @default.
• W3163812047 cites W2086885179 @default.
• W3163812047 cites W2088358452 @default.
• W3163812047 cites W2091209465 @default.
• W3163812047 cites W2127114472 @default.
• W3163812047 cites W2128749725 @default.
• W3163812047 cites W2129868828 @default.
• W3163812047 cites W2140201388 @default.
• W3163812047 cites W2145465887 @default.
• W3163812047 cites W2163918857 @default.
• W3163812047 cites W2169214568 @default.
• W3163812047 cites W22541073 @default.
• W3163812047 cites W2534021820 @default.
• W3163812047 cites W2605576042 @default.
• W3163812047 cites W2724667872 @default.
• W3163812047 cites W2762344252 @default.
• W3163812047 cites W2797856206 @default.
• W3163812047 cites W2999723508 @default.
• W3163812047 cites W3083996110 @default.
• W3163812047 cites W3089184362 @default.
• W3163812047 cites W3112081239 @default.
• W3163812047 cites W4210615564 @default.
• W3163812047 cites W4239233660 @default.
• W3163812047 doi "https://doi.org/10.1016/j.nlm.2021.107458" @default.
• W3163812047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8319050" @default.
• W3163812047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34015439" @default.
• W3163812047 hasPublicationYear "2021" @default.
• W3163812047 type Work @default.
• W3163812047 sameAs 3163812047 @default.
• W3163812047 citedByCount "9" @default.
• W3163812047 countsByYear W31638120472021 @default.
• W3163812047 countsByYear W31638120472022 @default.
• W3163812047 countsByYear W31638120472023 @default.
• W3163812047 crossrefType "journal-article" @default.
• W3163812047 hasAuthorship W3163812047A5029845153 @default.
• W3163812047 hasAuthorship W3163812047A5034789487 @default.
• W3163812047 hasAuthorship W3163812047A5037894723 @default.
• W3163812047 hasAuthorship W3163812047A5039619508 @default.
• W3163812047 hasAuthorship W3163812047A5042942785 @default.
• W3163812047 hasAuthorship W3163812047A5053569878 @default.
• W3163812047 hasBestOaLocation W31638120472 @default.
• W3163812047 hasConcept C101991246 @default.
• W3163812047 hasConcept C146926590 @default.
• W3163812047 hasConcept C148762608 @default.
• W3163812047 hasConcept C151730666 @default.
• W3163812047 hasConcept C15744967 @default.
• W3163812047 hasConcept C169760540 @default.
• W3163812047 hasConcept C185592680 @default.
• W3163812047 hasConcept C199289684 @default.
• W3163812047 hasConcept C2779343474 @default.
• W3163812047 hasConcept C2781161787 @default.
• W3163812047 hasConcept C86803240 @default.
• W3163812047 hasConceptScore W3163812047C101991246 @default.
• W3163812047 hasConceptScore W3163812047C146926590 @default.
• W3163812047 hasConceptScore W3163812047C148762608 @default.
• W3163812047 hasConceptScore W3163812047C151730666 @default.
• W3163812047 hasConceptScore W3163812047C15744967 @default.
• W3163812047 hasConceptScore W3163812047C169760540 @default.
• W3163812047 hasConceptScore W3163812047C185592680 @default.
• W3163812047 hasConceptScore W3163812047C199289684 @default.
• W3163812047 hasConceptScore W3163812047C2779343474 @default.
• W3163812047 hasConceptScore W3163812047C2781161787 @default.
• W3163812047 hasConceptScore W3163812047C86803240 @default.
• W3163812047 hasFunder F4320306147 @default.

• next