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• W3163884014 abstract "AIMS/ BACKGROUND OF STUDY The von Willebrand Factor (vWF) is a large procoagulant multimeric glycoprotein synthesized exclusively in endothelial cells and megakaryocytes and stored in the Weibel –Palade bodies and platelet -granules, respectively1. It serves two major functions in haemostasis, as carrier for VIII and as the ligand mediating platelet GPIb adhesion to collagen.2 The mechanisms that control plasma vWF: Ag concentration are multifactorial and poorly elucidated. Approximately 70% of variability is due to genetic factors3, of which the ABO blood group has been identified as the major influence.4 Several studies have consistently reported that group O subjects have lower plasma vWF levels than their non –group O counterparts.5 From those reports, it was also observed that the normal range of vWF: Ag in group O individuals extends below 50 IU/dl, which is commonly accepted as the lower limit of normal. Accordingly, O group individuals may or may not be at greater risk for bleeding and are more likely to be diagnosed with mild von Willebrand Disease. However, there is no demonstrable effect of Rh blood group on plasma vWF: Ag level in the literature. This study therefore aims to establish the ABO –specific, and possibly RhD– specific reference range for vWF: Ag in Blood Donors for the purpose of determining its clinical value in estimating the prevalence of von Willebrand Disease. Methodology: A cross-sectional analytical study was conducted to determine the vWF: Ag levels and some haemostatic parameters among Blood Donors at University of Uyo Teaching Hospital, Uyo – Akwa Ibom State. One hundred (100), subjects who met the inclusion criteria were recruited into the study. A pre-tested and structured questionnaire was administered to each participant. Complete blood count along with red cell indices were determined using Haematology auto-analyzer. Baseline Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were done using PT/APTT reagent as described in Dacie and Lewis.69 14 Determination of ABO and RhD Blood Grouping was done using the standard tube method. 70 von-Willebrand Factor Antigen Levels were assayed using a quantitative sandwich immune assay technique. Data obtained were analyzed with EPI info version 3.5.1 August 2008 software. Chi-square was used to determine significant association and a P-value of <0.05 was considered statistically significant. Results: The mean age of the respondents was 31.7 years  6.39 with a range of 21 to 53 years. 85% of the subjects were younger than 40 years and 15% were 40 years and older. The prevalence of O, A, B and AB blood groups was 50%, 31%, 16% and 3%, respectively. RhD+ phenotype accounted for 95% while RhD- phenotype constituted 5%. The overall mean plasma vWF:Ag concentration of the subjects was 1:38  1.02IU/ml. The reference range for vWF:Ag in the index population was expressed as the interquartile range of 0.84 – 1.49 IU/Ml with a median of 1.14 and skewness of 2.66. There was a statistically significant relationship between the ABO blood groups but not RhD blood groups and the mean plasma vWF:Ag levels of the donors. Also, a statistically significant relationship was observed between the plasma vWF:Ag concentration and the sex of blood donors. There was no statistically significant relationship between the ethnic origins of the subjects or the age of the donor within the 21-53 year range and the mean plasma vWF:Ag levels. Conclusion: The plasma vWF:Ag levels in healthy Nigerian subjects vary widely. It is evident that ABO group but not RhD blood group and the gender of the subjects are important modulators of the plasma vWF:Ag levels and need to be taken into cognizance when establishing reference range for vWF:Ag. The study suggested that age and ethnic origins of the donors do not influence their plasma vWF:Ag levels. These observations may be due to the small sample size and the absence of elderly subjects in this study. This therefore reinforces the compelling need to conduct a larger study, including one that deliberately targets the elderly population in order to confirm or controvert the aforementioned findings." @default.
• W3163884014 created "2021-05-24" @default.
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• W3163884014 date "2014-01-01" @default.
• W3163884014 modified "2023-09-27" @default.
• W3163884014 title "A STUDY OF von-WILLEBRAND FACTOR ANTIGEN LEVELS AND SOME HAEMOSTATIC PARAMETERS AMONG BLOOD DONORS AT UNIVERSITY OF UYO TEACHING HOSPITAL (UUTH)" @default.
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