Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163933192> ?p ?o ?g. }
- W3163933192 endingPage "966" @default.
- W3163933192 startingPage "958" @default.
- W3163933192 abstract "Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) show sex differences; and (ii) whether such sex differences may occur in cognitively intact elderly individuals.We first analysed the entire post-mortem brain collection of all non-demented 'controls' and AD donors from our Brain Bank (245 men and 403 women), for the presence of sex differences in AD hallmarks. Second, we quantitatively studied possible sex differences in Aβ, Aβ42 and p-Tau in the entorhinal cortex of well-matched female (n = 31) and male (n = 21) clinically cognitively intact elderly individuals.Women had significantly higher Braak stages for tangles and amyloid scores than men, after 80 years. In the cognitively intact elderly, women showed higher levels of p-Tau, but not Aβ or Aβ42, in the entorhinal cortex than men, and a significant interaction of sex with age was found only for p-Tau but not Aβ or Aβ42.Enhanced p-Tau in the entorhinal cortex may play a major role in the vulnerability to AD in women." @default.
- W3163933192 created "2021-05-24" @default.
- W3163933192 creator A5006717545 @default.
- W3163933192 creator A5007992589 @default.
- W3163933192 creator A5015779145 @default.
- W3163933192 creator A5026108717 @default.
- W3163933192 creator A5041129618 @default.
- W3163933192 creator A5052518485 @default.
- W3163933192 creator A5053722617 @default.
- W3163933192 creator A5064071210 @default.
- W3163933192 creator A5077660776 @default.
- W3163933192 date "2021-05-27" @default.
- W3163933192 modified "2023-09-27" @default.
- W3163933192 title "Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals" @default.
- W3163933192 cites W1481032361 @default.
- W3163933192 cites W1521517668 @default.
- W3163933192 cites W1644143258 @default.
- W3163933192 cites W1792810936 @default.
- W3163933192 cites W1808559002 @default.
- W3163933192 cites W1967464880 @default.
- W3163933192 cites W1975216966 @default.
- W3163933192 cites W1988332799 @default.
- W3163933192 cites W1993465897 @default.
- W3163933192 cites W1993571512 @default.
- W3163933192 cites W2002930469 @default.
- W3163933192 cites W2004385393 @default.
- W3163933192 cites W2013992160 @default.
- W3163933192 cites W2017059429 @default.
- W3163933192 cites W2025590886 @default.
- W3163933192 cites W2029580869 @default.
- W3163933192 cites W2042778267 @default.
- W3163933192 cites W2044241508 @default.
- W3163933192 cites W2052742260 @default.
- W3163933192 cites W2053116497 @default.
- W3163933192 cites W2066792703 @default.
- W3163933192 cites W2069121057 @default.
- W3163933192 cites W2084210522 @default.
- W3163933192 cites W2093282284 @default.
- W3163933192 cites W2096429475 @default.
- W3163933192 cites W2101077392 @default.
- W3163933192 cites W2128969673 @default.
- W3163933192 cites W2129497119 @default.
- W3163933192 cites W2133719476 @default.
- W3163933192 cites W2148080316 @default.
- W3163933192 cites W2151252981 @default.
- W3163933192 cites W2159285109 @default.
- W3163933192 cites W2233737392 @default.
- W3163933192 cites W2285813168 @default.
- W3163933192 cites W2295872797 @default.
- W3163933192 cites W2328745627 @default.
- W3163933192 cites W2415660587 @default.
- W3163933192 cites W2418237732 @default.
- W3163933192 cites W2472731799 @default.
- W3163933192 cites W2521386666 @default.
- W3163933192 cites W2557728905 @default.
- W3163933192 cites W2596231972 @default.
- W3163933192 cites W2600002013 @default.
- W3163933192 cites W2897712355 @default.
- W3163933192 cites W2902636119 @default.
- W3163933192 cites W3022734613 @default.
- W3163933192 cites W3163933192 @default.
- W3163933192 doi "https://doi.org/10.1111/nan.12729" @default.
- W3163933192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33969531" @default.
- W3163933192 hasPublicationYear "2021" @default.
- W3163933192 type Work @default.
- W3163933192 sameAs 3163933192 @default.
- W3163933192 citedByCount "5" @default.
- W3163933192 countsByYear W31639331922021 @default.
- W3163933192 countsByYear W31639331922022 @default.
- W3163933192 countsByYear W31639331922023 @default.
- W3163933192 crossrefType "journal-article" @default.
- W3163933192 hasAuthorship W3163933192A5006717545 @default.
- W3163933192 hasAuthorship W3163933192A5007992589 @default.
- W3163933192 hasAuthorship W3163933192A5015779145 @default.
- W3163933192 hasAuthorship W3163933192A5026108717 @default.
- W3163933192 hasAuthorship W3163933192A5041129618 @default.
- W3163933192 hasAuthorship W3163933192A5052518485 @default.
- W3163933192 hasAuthorship W3163933192A5053722617 @default.
- W3163933192 hasAuthorship W3163933192A5064071210 @default.
- W3163933192 hasAuthorship W3163933192A5077660776 @default.
- W3163933192 hasBestOaLocation W31639331922 @default.
- W3163933192 hasConcept C126322002 @default.
- W3163933192 hasConcept C15744967 @default.
- W3163933192 hasConcept C169760540 @default.
- W3163933192 hasConcept C2778945730 @default.
- W3163933192 hasConcept C2779134260 @default.
- W3163933192 hasConcept C2779483572 @default.
- W3163933192 hasConcept C2780130745 @default.
- W3163933192 hasConcept C2780715579 @default.
- W3163933192 hasConcept C2781161787 @default.
- W3163933192 hasConcept C502032728 @default.
- W3163933192 hasConcept C71924100 @default.
- W3163933192 hasConceptScore W3163933192C126322002 @default.
- W3163933192 hasConceptScore W3163933192C15744967 @default.
- W3163933192 hasConceptScore W3163933192C169760540 @default.
- W3163933192 hasConceptScore W3163933192C2778945730 @default.
- W3163933192 hasConceptScore W3163933192C2779134260 @default.
- W3163933192 hasConceptScore W3163933192C2779483572 @default.