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- W3163954673 endingPage "102641" @default.
- W3163954673 startingPage "102641" @default.
- W3163954673 abstract "Enzymes are promising catalysts with high selectivity and activity under mild reaction conditions. However, their practical application has largely been hindered by their high cost and poor stability. Metal-organic frameworks (MOFs) as host materials show potential in protecting proteins against denaturing conditions, but a systematic study investigating the stabilizing mechanism is still lacking. In this study, we stabilized enzyme cytochrome c (cyt c) by encapsulating it in a hierarchical mesoporous zirconium-based MOF, NU-1000 against denaturing organic solvents. Cyt c@NU-1000 showed a significantly enhanced activity compared to the native enzyme, and the composite retained this enhanced activity after treatment with five denaturing organic solvents. Moreover, the composite was recyclable without activity loss for at least three cycles. Our cyt c@NU-1000 model system demonstrates that [email protected] composites prepared via post-synthetic encapsulation offer a promising route to overcome the challenges of enzyme stability and recyclability that impede the widespread adoption of biocatalysis." @default.
- W3163954673 created "2021-06-07" @default.
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- W3163954673 creator A5081812461 @default.
- W3163954673 creator A5091444928 @default.
- W3163954673 date "2021-06-01" @default.
- W3163954673 modified "2023-10-18" @default.
- W3163954673 title "Stabilization of an enzyme cytochrome c in a metal-organic framework against denaturing organic solvents" @default.
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- W3163954673 doi "https://doi.org/10.1016/j.isci.2021.102641" @default.
- W3163954673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8192563" @default.
- W3163954673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34151233" @default.
- W3163954673 hasPublicationYear "2021" @default.
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