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- W3163957076 abstract "Clinical efficacy of chemotherapy is often compromised by diabetogenic glucose on colorectal cancer (CRC). High glucose has been shown to diminish the cytotoxicity of anticancer drugs. The issue can potentially be addressed with natural products. Recently, we revealed that Ganoderma neo-japonicum exhibits inhibitory activities against human colonic carcinoma cells. In this study, the impacts of hexane fraction (Hex, sterol-enriched) and chloroform fraction (Chl, terpenoid-enriched) were further elucidated. The cellular responses, including oxidative stress, cell cycle, and apoptosis were compared between the presence of normal glucose (NG, 5.5 mM) and high glucose (HG, 25 mM). HG promoted cell viability with concomitant elevation of GSH level. Both Hex and Chl fractions stimulated NO production, in addition, induced cell cycle arrest. The apoptotic effect of Hex fraction was glucose-dependent, but Chl fraction triggered apoptosis with an equivalent extent in NG and HG conditions. Overall, the active fractions from G. neo-japonicum show therapeutic potential in managing hyperglycemia-associated CRC." @default.
- W3163957076 created "2021-06-07" @default.
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- W3163957076 date "2021-06-04" @default.
- W3163957076 modified "2023-09-26" @default.
- W3163957076 title "<i>In vitro</i>Anti-colorectal Cancer Potential of the Medicinal Mushroom<i>Ganoderma neo-japonicum</i>Imazeki in Hyperglycemic Condition: Impact on Oxidative Stress, Cell Cycle and Apoptosis" @default.
- W3163957076 cites W1806048655 @default.
- W3163957076 cites W1966761325 @default.
- W3163957076 cites W1976666971 @default.
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- W3163957076 cites W1984405841 @default.
- W3163957076 cites W1985207595 @default.
- W3163957076 cites W1988948899 @default.
- W3163957076 cites W1989764065 @default.
- W3163957076 cites W1990363059 @default.
- W3163957076 cites W1994995968 @default.
- W3163957076 cites W2007185373 @default.
- W3163957076 cites W2007668413 @default.
- W3163957076 cites W2008757142 @default.
- W3163957076 cites W2009618167 @default.
- W3163957076 cites W2011485160 @default.
- W3163957076 cites W2015026597 @default.
- W3163957076 cites W2020242649 @default.
- W3163957076 cites W2022059814 @default.
- W3163957076 cites W2025404088 @default.
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- W3163957076 cites W2055354965 @default.
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- W3163957076 doi "https://doi.org/10.1080/01635581.2021.1931701" @default.
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