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• W3163960069 abstract "Metabotropic γ-aminobutyric acid G protein-coupled receptors (GABAB) represent one of the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act both pre- and postsynaptically by modulating the transmission of neuronal signals and are involved in a range of neurological diseases, from alcohol addiction to epilepsy. A series of recent cryo-EM studies revealed critical details of the activation mechanism of GABAB Structures are now available for the receptor bound to ligands with different modes of action, including antagonists, agonists, and positive allosteric modulators, and captured in different conformational states from the inactive apo to the fully active state bound to a G protein. These discoveries provide comprehensive insights into the activation of the GABAB receptor, which not only broaden our understanding of its structure, pharmacology, and physiological effects but also will ultimately facilitate the discovery of new therapeutic drugs and neuromodulators." @default.
• W3163960069 created "2021-06-07" @default.
• W3163960069 creator A5026017022 @default.
• W3163960069 creator A5035030436 @default.
• W3163960069 creator A5057336284 @default.
• W3163960069 creator A5063729267 @default.
• W3163960069 date "2021-05-28" @default.
• W3163960069 modified "2023-09-30" @default.
• W3163960069 title "Molecular mechanisms of metabotropic GABA _B receptor function" @default.
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