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- W3163987893 abstract "Abstract Introduction Representation of Mexican Americans in Alzheimer's disease (AD) clinical research has been extremely poor. Methods Data were examined from the ongoing community‐based, multi‐ethnic Health & Aging Brain among Latino Elders (HABLE) study. Participants underwent functional exams, clinical labs, neuropsychological testing, and 3T magnetic resonance imaging of the brain. Fasting proteomic markers were examined for predicting mild cognitive impairment (MCI) and AD using support vector machine models. Results Data were examined from n = 1649 participants (Mexican American n = 866; non‐Hispanic White n = 783). Proteomic profiles were highly accurate in detecting MCI (area under the curve [AUC] = 0.91) and dementia (AUC = 0.95). The proteomic profiles varied significantly between ethnic groups and disease state. Negative predictive value was excellent for ruling out MCI and dementia across ethnic groups. Discussion A blood‐based screening tool can serve as a method for increasing access to state‐of‐the‐art AD clinical research by bridging between community‐based and clinic‐based settings." @default.
- W3163987893 created "2021-06-07" @default.
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- W3163987893 date "2021-05-31" @default.
- W3163987893 modified "2023-10-09" @default.
- W3163987893 title "A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community‐dwelling Mexican Americans and non‐Hispanic Whites: A method for increasing representation of diverse populations in clinical research" @default.
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- W3163987893 doi "https://doi.org/10.1002/alz.12382" @default.
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