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• W3163996486 abstract "BackgroundHigher leptin and lower adiponectin levels have been linked to progressing systemic inflammation and diseases of aging. Among older adults with obesity and an inflammatory conditions, we quantified effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on leptin, adiponectin, and the leptin-to-adiponectin ratio (LAR). We also examined associations among adipokine and cytokine levels.MethodsUsing a randomized, double-blind, placebo-controlled design, participants (mean age 61.3 ± 2.1) received 1.5 g EPA + 1.0 g DHA (n = 14) or mineral oil (n = 18) daily. Plasma adipokine and cytokine levels were quantified by electrochemiluminescence at all study intervals.ResultsWhile no between-group differences were detected, there was a reduction in the LAR (by 23%, p=.065) between weeks 4 and 8 among the EPA+DHA group. Adiponectin levels were negatively associated with IL-1β levels at week 4 (p=.02) and TNF-α levels at week 8 (p=.03).ConclusionPotential benefits of EPA+DHA supplementation among aging populations warrant further study." @default.
• W3163996486 created "2021-06-07" @default.
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• W3163996486 date "2021-07-01" @default.
• W3163996486 modified "2023-09-27" @default.
• W3163996486 title "Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults" @default.
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• W3163996486 doi "https://doi.org/10.1016/j.plefa.2021.102302" @default.
• W3163996486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34077887" @default.
• W3163996486 hasPublicationYear "2021" @default.
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