Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164030506> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3164030506 abstract "Abstract Background Acute myeloid leukemia (AML) is a heterogeneous malignant disease characterized by accumulation of different types of mutations commonly the CCAAT/enhancer binding protein-alpha ( CEBPA ). However, the dysregulations of CEBPA expression in AML is still a debatable issue. The aim of the current study was to assess CEBPA gene expression in bone marrow (BM) aspiration specimens of 91 AML patients, compared to 20 control donors of bone marrow transplantation (BMT), using RT-PCR. Data were correlated with patients’ clinico-pathological features, response to treatment, progression-free survival (PFS), and overall survival (OS) rates. Results There was overexpression of CEBPA gene in AML patients compared to normal control [1.7 (0.04–25.6) versus 0.17 (0–4.78), respectively, P < 0.001]. Upregulation of CEBPA expression associated significantly with increased BM hypercellularity, total leucocyte counts, peripheral blood blast cell count, and poor PFS ( P < 0.001, 0.002, 0.001, and 0.013, respectively). There was no significant association between CEBPA expression and any other relevant clinico-pathological features or OS rates ( P = 0.610) of the patients. ROC analysis for biological relevance of CEBPA expression with AML showed that sensitivity and specificity of CEBPA expression at a cut-off value of 0.28 are 92.3% and 78.6%, respectively ( P < 0.001). All patients who had CEBPA overexpression and mutant FLT3 showed BM hypercellularity, adverse cytogenetic risk, increased TLC, and PB blast cells count ( P = 0.007, P < 0.001, 0.016, and 0.002, respectively). Conclusion CEBPA overexpression could be used as a genetic biological marker for AML diagnosis, as well as a poor prognostic factor for disease progression. It has no impact on OS rates of the patients." @default.
- W3164030506 created "2021-06-07" @default.
- W3164030506 creator A5033406657 @default.
- W3164030506 creator A5044223188 @default.
- W3164030506 creator A5065287916 @default.
- W3164030506 creator A5066103848 @default.
- W3164030506 date "2021-04-22" @default.
- W3164030506 modified "2023-09-24" @default.
- W3164030506 title "Dysregulation of CCAAT/enhancer binding protein-alpha (CEBPA) expression in the bone marrow of acute myeloid leukemia patients" @default.
- W3164030506 cites W1255676896 @default.
- W3164030506 cites W1489323849 @default.
- W3164030506 cites W1965113891 @default.
- W3164030506 cites W2008946411 @default.
- W3164030506 cites W2015507761 @default.
- W3164030506 cites W2039905566 @default.
- W3164030506 cites W2040454446 @default.
- W3164030506 cites W2043216151 @default.
- W3164030506 cites W2056777862 @default.
- W3164030506 cites W2086915316 @default.
- W3164030506 cites W2092288325 @default.
- W3164030506 cites W2107277218 @default.
- W3164030506 cites W2122671437 @default.
- W3164030506 cites W2127621383 @default.
- W3164030506 cites W2131346805 @default.
- W3164030506 cites W2154625299 @default.
- W3164030506 cites W2310716991 @default.
- W3164030506 cites W2461928138 @default.
- W3164030506 cites W2559537906 @default.
- W3164030506 cites W2579083698 @default.
- W3164030506 cites W2584342052 @default.
- W3164030506 cites W2756171353 @default.
- W3164030506 cites W2770841484 @default.
- W3164030506 cites W2902725436 @default.
- W3164030506 cites W2956766018 @default.
- W3164030506 cites W2969647405 @default.
- W3164030506 doi "https://doi.org/10.1186/s43042-021-00154-z" @default.
- W3164030506 hasPublicationYear "2021" @default.
- W3164030506 type Work @default.
- W3164030506 sameAs 3164030506 @default.
- W3164030506 citedByCount "2" @default.
- W3164030506 countsByYear W31640305062022 @default.
- W3164030506 crossrefType "journal-article" @default.
- W3164030506 hasAuthorship W3164030506A5033406657 @default.
- W3164030506 hasAuthorship W3164030506A5044223188 @default.
- W3164030506 hasAuthorship W3164030506A5065287916 @default.
- W3164030506 hasAuthorship W3164030506A5066103848 @default.
- W3164030506 hasBestOaLocation W31640305061 @default.
- W3164030506 hasConcept C104317684 @default.
- W3164030506 hasConcept C126322002 @default.
- W3164030506 hasConcept C2778461978 @default.
- W3164030506 hasConcept C2778729363 @default.
- W3164030506 hasConcept C2779282312 @default.
- W3164030506 hasConcept C2780007613 @default.
- W3164030506 hasConcept C45091340 @default.
- W3164030506 hasConcept C501734568 @default.
- W3164030506 hasConcept C502942594 @default.
- W3164030506 hasConcept C55493867 @default.
- W3164030506 hasConcept C71924100 @default.
- W3164030506 hasConcept C86803240 @default.
- W3164030506 hasConceptScore W3164030506C104317684 @default.
- W3164030506 hasConceptScore W3164030506C126322002 @default.
- W3164030506 hasConceptScore W3164030506C2778461978 @default.
- W3164030506 hasConceptScore W3164030506C2778729363 @default.
- W3164030506 hasConceptScore W3164030506C2779282312 @default.
- W3164030506 hasConceptScore W3164030506C2780007613 @default.
- W3164030506 hasConceptScore W3164030506C45091340 @default.
- W3164030506 hasConceptScore W3164030506C501734568 @default.
- W3164030506 hasConceptScore W3164030506C502942594 @default.
- W3164030506 hasConceptScore W3164030506C55493867 @default.
- W3164030506 hasConceptScore W3164030506C71924100 @default.
- W3164030506 hasConceptScore W3164030506C86803240 @default.
- W3164030506 hasIssue "1" @default.
- W3164030506 hasLocation W31640305061 @default.
- W3164030506 hasOpenAccess W3164030506 @default.
- W3164030506 hasPrimaryLocation W31640305061 @default.
- W3164030506 hasRelatedWork W2007520265 @default.
- W3164030506 hasRelatedWork W2037525802 @default.
- W3164030506 hasRelatedWork W2089686547 @default.
- W3164030506 hasRelatedWork W2118645968 @default.
- W3164030506 hasRelatedWork W2121159001 @default.
- W3164030506 hasRelatedWork W2360105106 @default.
- W3164030506 hasRelatedWork W2588321737 @default.
- W3164030506 hasRelatedWork W3096241657 @default.
- W3164030506 hasRelatedWork W42711520 @default.
- W3164030506 hasRelatedWork W4320019111 @default.
- W3164030506 hasVolume "22" @default.
- W3164030506 isParatext "false" @default.
- W3164030506 isRetracted "false" @default.
- W3164030506 magId "3164030506" @default.
- W3164030506 workType "article" @default.