Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164041179> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3164041179 endingPage "836" @default.
- W3164041179 startingPage "827" @default.
- W3164041179 abstract "Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly expanded; however, clinical trials excluded patients taking immunosuppressive medications such as those with inflammatory bowel disease (IBD). Therefore, we explored real-world effectiveness of coronavirus disease 2019 (COVID-19) vaccination on subsequent infection in patients with IBD with diverse exposure to immunosuppressive medications.This was a retrospective cohort study of patients in the Veterans Health Administration with IBD diagnosed before December 18, 2020, the start date of the Veterans Health Administration patient vaccination program. IBD medication exposures included mesalamine, thiopurines, anti-tumor necrosis factor biologic agents, vedolizumab, ustekinumab, tofacitinib, methotrexate, and corticosteroid use. We used inverse probability weighting and Cox's regression with vaccination status as a time-updating exposure and computed vaccine effectiveness from incidence rates.The cohort comprised 14,697 patients, 7321 of whom received at least 1 vaccine dose (45.2% Pfizer, 54.8% Moderna). The cohort had median age 68 years, 92.2% were men, 80.4% were White, and 61.8% had ulcerative colitis. In follow-up data through April 20, 2021, unvaccinated individuals had the highest raw proportion of SARS-CoV-2 infection (197 [1.34%] vs 7 [0.11%] fully vaccinated). Full vaccination status, but not partial vaccination status, was associated with a 69% reduced hazard of infection relative to an unvaccinated status (hazard ratio, 0.31, 95% confidence interval, 0.17-0.56; P < .001), corresponding to an 80.4% effectiveness.Full vaccination (> 7 days after the second dose) against SARS-CoV-2 infection has an ∼80.4% effectiveness in a broad IBD cohort with diverse exposure to immunosuppressive medications. These results may serve to increase patient and provider willingness to pursue vaccination in these settings." @default.
- W3164041179 created "2021-06-07" @default.
- W3164041179 creator A5058696857 @default.
- W3164041179 creator A5071070019 @default.
- W3164041179 date "2021-09-01" @default.
- W3164041179 modified "2023-09-30" @default.
- W3164041179 title "Effectiveness of SARS-CoV-2 Vaccination in a Veterans Affairs Cohort of Patients With Inflammatory Bowel Disease With Diverse Exposure to Immunosuppressive Medications" @default.
- W3164041179 cites W1968626666 @default.
- W3164041179 cites W2091962789 @default.
- W3164041179 cites W2110818436 @default.
- W3164041179 cites W2126049444 @default.
- W3164041179 cites W2172099787 @default.
- W3164041179 cites W2492495737 @default.
- W3164041179 cites W2782178538 @default.
- W3164041179 cites W2797152839 @default.
- W3164041179 cites W3006764495 @default.
- W3164041179 cites W3021115216 @default.
- W3164041179 cites W3022587459 @default.
- W3164041179 cites W3022795287 @default.
- W3164041179 cites W3087924281 @default.
- W3164041179 cites W3093912912 @default.
- W3164041179 cites W3111255098 @default.
- W3164041179 cites W3131688063 @default.
- W3164041179 cites W3136040564 @default.
- W3164041179 cites W3136504413 @default.
- W3164041179 cites W3199488937 @default.
- W3164041179 cites W4205483821 @default.
- W3164041179 cites W4237793533 @default.
- W3164041179 cites W4376596210 @default.
- W3164041179 doi "https://doi.org/10.1053/j.gastro.2021.05.044" @default.
- W3164041179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8146263" @default.
- W3164041179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34048782" @default.
- W3164041179 hasPublicationYear "2021" @default.
- W3164041179 type Work @default.
- W3164041179 sameAs 3164041179 @default.
- W3164041179 citedByCount "83" @default.
- W3164041179 countsByYear W31640411792021 @default.
- W3164041179 countsByYear W31640411792022 @default.
- W3164041179 countsByYear W31640411792023 @default.
- W3164041179 crossrefType "journal-article" @default.
- W3164041179 hasAuthorship W3164041179A5058696857 @default.
- W3164041179 hasAuthorship W3164041179A5071070019 @default.
- W3164041179 hasBestOaLocation W31640411791 @default.
- W3164041179 hasConcept C126322002 @default.
- W3164041179 hasConcept C203014093 @default.
- W3164041179 hasConcept C207103383 @default.
- W3164041179 hasConcept C22070199 @default.
- W3164041179 hasConcept C2775969662 @default.
- W3164041179 hasConcept C2776207728 @default.
- W3164041179 hasConcept C2778260677 @default.
- W3164041179 hasConcept C2779134260 @default.
- W3164041179 hasConcept C2780479503 @default.
- W3164041179 hasConcept C44249647 @default.
- W3164041179 hasConcept C71924100 @default.
- W3164041179 hasConcept C72563966 @default.
- W3164041179 hasConceptScore W3164041179C126322002 @default.
- W3164041179 hasConceptScore W3164041179C203014093 @default.
- W3164041179 hasConceptScore W3164041179C207103383 @default.
- W3164041179 hasConceptScore W3164041179C22070199 @default.
- W3164041179 hasConceptScore W3164041179C2775969662 @default.
- W3164041179 hasConceptScore W3164041179C2776207728 @default.
- W3164041179 hasConceptScore W3164041179C2778260677 @default.
- W3164041179 hasConceptScore W3164041179C2779134260 @default.
- W3164041179 hasConceptScore W3164041179C2780479503 @default.
- W3164041179 hasConceptScore W3164041179C44249647 @default.
- W3164041179 hasConceptScore W3164041179C71924100 @default.
- W3164041179 hasConceptScore W3164041179C72563966 @default.
- W3164041179 hasIssue "3" @default.
- W3164041179 hasLocation W31640411791 @default.
- W3164041179 hasLocation W31640411792 @default.
- W3164041179 hasLocation W31640411793 @default.
- W3164041179 hasOpenAccess W3164041179 @default.
- W3164041179 hasPrimaryLocation W31640411791 @default.
- W3164041179 hasRelatedWork W1864880157 @default.
- W3164041179 hasRelatedWork W2033059461 @default.
- W3164041179 hasRelatedWork W2064867978 @default.
- W3164041179 hasRelatedWork W2169313409 @default.
- W3164041179 hasRelatedWork W2221971298 @default.
- W3164041179 hasRelatedWork W2341879915 @default.
- W3164041179 hasRelatedWork W3007087481 @default.
- W3164041179 hasRelatedWork W4239741646 @default.
- W3164041179 hasRelatedWork W4244220285 @default.
- W3164041179 hasRelatedWork W4249500390 @default.
- W3164041179 hasVolume "161" @default.
- W3164041179 isParatext "false" @default.
- W3164041179 isRetracted "false" @default.
- W3164041179 magId "3164041179" @default.
- W3164041179 workType "article" @default.