Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164095932> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3164095932 abstract "Abstract Recently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein, we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring mode for the simultaneous determination of four N-nitrosamines in sartan substances, namely, N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodibutylamine, and N-nitrosodiisopropylamine. The conditions of gas chromatography and mass spectrometry were optimized. The method was validated according to the International Council for Harmonization guidelines in terms of sensitivity, linearity, accuracy, precision, specificity, and stability. The limits of detection of N-nitrosamines in sartan substances ranged from 0.002 to 0.150 ppm, and the corresponding limits of quantification were in the range of 0.008-0.500 ppm, which met the sensitivity requirements for the limits set by the Food and Drug Administration of the United States. The internal standard curve of four N-nitrosamines showed good linearity of regression coefficients over 0.99. The recoveries of N-nitrosamines in selected sartan drugs ranged from 87.68 to 123.76%. The intraday and interday relative standard deviation values were less than 9.15%. Therefore, this proposed method exhibited good sensitivity and precision, high accuracy, and fast analysis speed, which provide a reliable method for quality control of N-nitrosamines in sartan products." @default.
- W3164095932 created "2021-06-07" @default.
- W3164095932 creator A5004145498 @default.
- W3164095932 creator A5017542783 @default.
- W3164095932 creator A5054979130 @default.
- W3164095932 creator A5058219030 @default.
- W3164095932 creator A5058381047 @default.
- W3164095932 creator A5078719624 @default.
- W3164095932 creator A5079989420 @default.
- W3164095932 creator A5085672523 @default.
- W3164095932 creator A5090626048 @default.
- W3164095932 date "2021-01-08" @default.
- W3164095932 modified "2023-10-07" @default.
- W3164095932 title "Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances" @default.
- W3164095932 cites W1579921232 @default.
- W3164095932 cites W1580554406 @default.
- W3164095932 cites W1980467529 @default.
- W3164095932 cites W1981011108 @default.
- W3164095932 cites W2008016632 @default.
- W3164095932 cites W2018620514 @default.
- W3164095932 cites W2045982281 @default.
- W3164095932 cites W2056068268 @default.
- W3164095932 cites W2062226211 @default.
- W3164095932 cites W2097774007 @default.
- W3164095932 cites W2100301199 @default.
- W3164095932 cites W2163433231 @default.
- W3164095932 cites W2328014372 @default.
- W3164095932 cites W2474711668 @default.
- W3164095932 cites W2558959170 @default.
- W3164095932 cites W2597037461 @default.
- W3164095932 cites W2606176826 @default.
- W3164095932 cites W2901115243 @default.
- W3164095932 cites W2913590482 @default.
- W3164095932 cites W2936940612 @default.
- W3164095932 cites W2943967011 @default.
- W3164095932 cites W2947654309 @default.
- W3164095932 cites W2969531068 @default.
- W3164095932 cites W2996828767 @default.
- W3164095932 doi "https://doi.org/10.1186/s40543-020-00254-2" @default.
- W3164095932 hasPublicationYear "2021" @default.
- W3164095932 type Work @default.
- W3164095932 sameAs 3164095932 @default.
- W3164095932 citedByCount "12" @default.
- W3164095932 countsByYear W31640959322021 @default.
- W3164095932 countsByYear W31640959322022 @default.
- W3164095932 countsByYear W31640959322023 @default.
- W3164095932 crossrefType "journal-article" @default.
- W3164095932 hasAuthorship W3164095932A5004145498 @default.
- W3164095932 hasAuthorship W3164095932A5017542783 @default.
- W3164095932 hasAuthorship W3164095932A5054979130 @default.
- W3164095932 hasAuthorship W3164095932A5058219030 @default.
- W3164095932 hasAuthorship W3164095932A5058381047 @default.
- W3164095932 hasAuthorship W3164095932A5078719624 @default.
- W3164095932 hasAuthorship W3164095932A5079989420 @default.
- W3164095932 hasAuthorship W3164095932A5085672523 @default.
- W3164095932 hasAuthorship W3164095932A5090626048 @default.
- W3164095932 hasBestOaLocation W31640959321 @default.
- W3164095932 hasConcept C114246631 @default.
- W3164095932 hasConcept C119128265 @default.
- W3164095932 hasConcept C123460561 @default.
- W3164095932 hasConcept C162356407 @default.
- W3164095932 hasConcept C178790620 @default.
- W3164095932 hasConcept C185592680 @default.
- W3164095932 hasConcept C2777395278 @default.
- W3164095932 hasConcept C43617362 @default.
- W3164095932 hasConceptScore W3164095932C114246631 @default.
- W3164095932 hasConceptScore W3164095932C119128265 @default.
- W3164095932 hasConceptScore W3164095932C123460561 @default.
- W3164095932 hasConceptScore W3164095932C162356407 @default.
- W3164095932 hasConceptScore W3164095932C178790620 @default.
- W3164095932 hasConceptScore W3164095932C185592680 @default.
- W3164095932 hasConceptScore W3164095932C2777395278 @default.
- W3164095932 hasConceptScore W3164095932C43617362 @default.
- W3164095932 hasFunder F4320321001 @default.
- W3164095932 hasFunder F4320321921 @default.
- W3164095932 hasIssue "1" @default.
- W3164095932 hasLocation W31640959321 @default.
- W3164095932 hasLocation W31640959322 @default.
- W3164095932 hasOpenAccess W3164095932 @default.
- W3164095932 hasPrimaryLocation W31640959321 @default.
- W3164095932 hasRelatedWork W1563160993 @default.
- W3164095932 hasRelatedWork W1980714464 @default.
- W3164095932 hasRelatedWork W2040542718 @default.
- W3164095932 hasRelatedWork W2106982482 @default.
- W3164095932 hasRelatedWork W2132790825 @default.
- W3164095932 hasRelatedWork W2328356236 @default.
- W3164095932 hasRelatedWork W2439878233 @default.
- W3164095932 hasRelatedWork W2605836324 @default.
- W3164095932 hasRelatedWork W2767494186 @default.
- W3164095932 hasRelatedWork W2165347555 @default.
- W3164095932 hasVolume "12" @default.
- W3164095932 isParatext "false" @default.
- W3164095932 isRetracted "false" @default.
- W3164095932 magId "3164095932" @default.
- W3164095932 workType "article" @default.