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- W3164126719 endingPage "380" @default.
- W3164126719 startingPage "365" @default.
- W3164126719 abstract "Microglia is the resident tissue macrophages of the central nervous system. Prolonged microglial activation often occurs after traumatic brain injury and is associated with deteriorating neurocognitive outcomes. Resolution of microglial activation is associated with limited tissue loss and improved neurocognitive outcomes. Limiting the prolonged pro-inflammatory response and the associated secondary tissue injury provides the rationale and scientific premise for considering microglia as a therapeutic target.In this review, we discuss markers of microglial activation, such as immunophenotype and microglial response to injury, including cytokine/chemokine release, free radical formation, morphology, phagocytosis, and metabolic shifts. We compare the origin and role in neuroinflammation of microglia and monocytes/macrophages. We review potential therapeutic targets to shift microglial polarization. Finally, we review the effect of cell therapy on microglia.Dysregulated microglial activation after neurologic injury, such as traumatic brain injury, can worsen tissue damage and functional outcomes. There are potential targets in microglia to attenuate this activation, such as proteins and molecules that regulate microglia polarization. Cellular therapeutics that limit, but do not eliminate, the inflammatory response have improved outcomes in animal models by reducing pro-inflammatory microglial activation via secondary signaling. These findings have been replicated in early phase clinical trials." @default.
- W3164126719 created "2021-06-07" @default.
- W3164126719 creator A5014998467 @default.
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- W3164126719 creator A5033942732 @default.
- W3164126719 creator A5051817613 @default.
- W3164126719 creator A5090373567 @default.
- W3164126719 date "2021-05-04" @default.
- W3164126719 modified "2023-10-06" @default.
- W3164126719 title "Microglia as therapeutic targets after neurological injury: strategy for cell therapy" @default.
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