FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164167003> ?p ?o ?g. }

• W3164167003 endingPage "1286" @default.
• W3164167003 startingPage "1261" @default.
• W3164167003 abstract "Introduction There continues to be an exponential rise in the number of small molecule drugs that contain either a fluorine atom or a fluorinated fragment. While the unique properties of fluorine enable the precise modulation of a molecule’s physicochemical properties, strategic bioisosteric replacement of fragments with fluorinated moieties represents an area of significant growth.Areas covered This review discusses the strategic employment of fluorine substitution in the design and development of bioisosteres in medicinal chemistry. In addition, the classic exploitation of trifluoroethylamine group as an amide bioisostere is discussed. In each of the case studies presented, emphasis is placed on the context-dependent influence of the fluorinated fragment on the overall properties/binding of the compound of interest.Expert opinion Whereas utilization of bioisosteric replacements to modify molecular structures is commonplace within drug discovery, the overarching lesson to be learned is that the chances of success with this strategy significantly increase as the knowledge of the structure/environment of the biological target grows. Coupled to this, breakthroughs and learnings achieved using bioisosteres within a specific program are context-based, and though may be helpful in guiding future intuition, will not necessarily be directly translated to future programs. Another important point is to bear in mind what implications a structural change based on a bioisosteric replacement will have on the candidate molecule. Finally, the development of new methods and reagents for the controlled regioselective introduction of fluorine and fluorinated moieties into biologically relevant compounds particularly in drug discovery remains a contemporary challenge in organic chemistry." @default.
• W3164167003 created "2021-06-07" @default.
• W3164167003 creator A5006108649 @default.
• W3164167003 date "2021-06-10" @default.
• W3164167003 modified "2023-10-10" @default.
• W3164167003 title "Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery" @default.
• W3164167003 cites W1582137960 @default.
• W3164167003 cites W1911648303 @default.
• W3164167003 cites W1924350753 @default.
• W3164167003 cites W1965448901 @default.
• W3164167003 cites W1967995519 @default.
• W3164167003 cites W1968019680 @default.
• W3164167003 cites W1969235092 @default.
• W3164167003 cites W1974678115 @default.
• W3164167003 cites W1974833464 @default.
• W3164167003 cites W1975947882 @default.
• W3164167003 cites W1976236953 @default.
• W3164167003 cites W1977499678 @default.
• W3164167003 cites W1977534471 @default.
• W3164167003 cites W1977682721 @default.
• W3164167003 cites W1980253503 @default.
• W3164167003 cites W1980809338 @default.
• W3164167003 cites W1982134384 @default.
• W3164167003 cites W1982384322 @default.
• W3164167003 cites W1983068302 @default.
• W3164167003 cites W1983401069 @default.
• W3164167003 cites W1985794439 @default.
• W3164167003 cites W1988020745 @default.
• W3164167003 cites W1988566244 @default.
• W3164167003 cites W1990393354 @default.
• W3164167003 cites W1991660464 @default.
• W3164167003 cites W1991931105 @default.
• W3164167003 cites W1992084132 @default.
• W3164167003 cites W1992812460 @default.
• W3164167003 cites W1994888966 @default.
• W3164167003 cites W1996819821 @default.
• W3164167003 cites W1999989614 @default.
• W3164167003 cites W2000342456 @default.
• W3164167003 cites W2000441252 @default.
• W3164167003 cites W2006683822 @default.
• W3164167003 cites W2009121506 @default.
• W3164167003 cites W2010433936 @default.
• W3164167003 cites W2010654750 @default.
• W3164167003 cites W2013351505 @default.
• W3164167003 cites W2014364284 @default.
• W3164167003 cites W2017636510 @default.
• W3164167003 cites W2017663351 @default.
• W3164167003 cites W2018621056 @default.
• W3164167003 cites W2027171343 @default.
• W3164167003 cites W2028065660 @default.
• W3164167003 cites W2028503582 @default.
• W3164167003 cites W2029348880 @default.
• W3164167003 cites W2030145184 @default.
• W3164167003 cites W2030841140 @default.
• W3164167003 cites W2032672550 @default.
• W3164167003 cites W2033043158 @default.
• W3164167003 cites W2033770158 @default.
• W3164167003 cites W2035906823 @default.
• W3164167003 cites W2037050025 @default.
• W3164167003 cites W2039007413 @default.
• W3164167003 cites W2040822208 @default.
• W3164167003 cites W2040826404 @default.
• W3164167003 cites W2040978904 @default.
• W3164167003 cites W2041472239 @default.
• W3164167003 cites W2044400161 @default.
• W3164167003 cites W2044452648 @default.
• W3164167003 cites W2044728970 @default.
• W3164167003 cites W2051601643 @default.
• W3164167003 cites W2052473263 @default.
• W3164167003 cites W2053030051 @default.
• W3164167003 cites W2053112965 @default.
• W3164167003 cites W2054117275 @default.
• W3164167003 cites W2054582528 @default.
• W3164167003 cites W2055346737 @default.
• W3164167003 cites W2056328992 @default.
• W3164167003 cites W2057509100 @default.
• W3164167003 cites W2057640071 @default.
• W3164167003 cites W2058042750 @default.
• W3164167003 cites W2058443040 @default.
• W3164167003 cites W2059326113 @default.
• W3164167003 cites W2059374780 @default.
• W3164167003 cites W2061464562 @default.
• W3164167003 cites W2061957367 @default.
• W3164167003 cites W2063915017 @default.
• W3164167003 cites W2064570326 @default.
• W3164167003 cites W2069799943 @default.
• W3164167003 cites W2069892381 @default.
• W3164167003 cites W2072771433 @default.
• W3164167003 cites W2075254748 @default.
• W3164167003 cites W2075756317 @default.
• W3164167003 cites W2076090516 @default.
• W3164167003 cites W2076227819 @default.
• W3164167003 cites W2078578691 @default.
• W3164167003 cites W2078653978 @default.
• W3164167003 cites W2078810943 @default.
• W3164167003 cites W2079795589 @default.
• W3164167003 cites W2079991727 @default.
• W3164167003 cites W2080377507 @default.

• next