FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164174591> ?p ?o ?g. }

• W3164174591 endingPage "592" @default.
• W3164174591 startingPage "575" @default.
• W3164174591 abstract "Background: Microglia contribute to Alzheimer’s disease (AD) pathogenesis by clearing amyloid-β (Aβ) and driving neuroinflammation. Domestic dogs with age-related dementia (canine cognitive dysfunction (CCD)) develop cerebral amyloidosis like humans developing AD, and studying such dogs can provide novel information about microglial response in prodromal AD. Objective: The aim was to investigate the microglial response in the cortical grey and the subcortical white matter in dogs with CCD versus age-matched cognitively normal dogs. Methods: Brains from aged dogs with CCD and age-matched controls without dementia were studied. Cases were defined by dementia rating score. Brain sections were stained for Aβ, thioflavin S, hyperphosphorylated tau, and the microglial-macrophage ionized calcium binding adaptor molecule 1 (Iba1). Results were correlated to dementia rating score and tissue levels of Aβ. Results: Microglial numbers were higher in the Aβ plaque-loaded deep cortical layers in CCD versus control dogs, while the coverage by microglial processes were comparable. Aβ plaques were of the diffuse type and without microglial aggregation. However, a correlation was found between the %Iba1 area and insoluble Aβ 42 and N-terminal pyroglutamate modified Aβ(N3pE)-42. The %Iba1 area was higher in white matter, showing phosphorylation of S396 tau, versus grey matter. Perivascular macrophage infiltrates were abundant in the white matter particularly in CDD dogs. Conclusion: The results from this study of the microglial-macrophage response in dogs with CCD are suggestive of relatively mild microglial responses in the Aβ plaque-loaded deep cortical layers and perivascular macrophage infiltrates in the subcortical white matter, in prodromal AD." @default.
• W3164174591 created "2021-06-07" @default.
• W3164174591 creator A5005931795 @default.
• W3164174591 creator A5013379516 @default.
• W3164174591 creator A5018130591 @default.
• W3164174591 creator A5020701133 @default.
• W3164174591 creator A5040998184 @default.
• W3164174591 creator A5043887541 @default.
• W3164174591 creator A5053918337 @default.
• W3164174591 creator A5064953301 @default.
• W3164174591 creator A5082085282 @default.
• W3164174591 creator A5082156683 @default.
• W3164174591 creator A5085286387 @default.
• W3164174591 date "2021-07-21" @default.
• W3164174591 modified "2023-10-18" @default.
• W3164174591 title "Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer’s Disease" @default.
• W3164174591 cites W1537685484 @default.
• W3164174591 cites W1675018259 @default.
• W3164174591 cites W1964944610 @default.
• W3164174591 cites W1974145718 @default.
• W3164174591 cites W1980768099 @default.
• W3164174591 cites W1989240666 @default.
• W3164174591 cites W1991805788 @default.
• W3164174591 cites W1993305977 @default.
• W3164174591 cites W1994832173 @default.
• W3164174591 cites W1995111570 @default.
• W3164174591 cites W2001618696 @default.
• W3164174591 cites W2002275590 @default.
• W3164174591 cites W2011485908 @default.
• W3164174591 cites W2017615265 @default.
• W3164174591 cites W2018332716 @default.
• W3164174591 cites W2018708829 @default.
• W3164174591 cites W2028607330 @default.
• W3164174591 cites W2034758703 @default.
• W3164174591 cites W2036642860 @default.
• W3164174591 cites W2040872965 @default.
• W3164174591 cites W2044315549 @default.
• W3164174591 cites W2045321639 @default.
• W3164174591 cites W2046202110 @default.
• W3164174591 cites W2047964142 @default.
• W3164174591 cites W2056716542 @default.
• W3164174591 cites W2060937867 @default.
• W3164174591 cites W2063894419 @default.
• W3164174591 cites W2066060763 @default.
• W3164174591 cites W2068354213 @default.
• W3164174591 cites W2071970728 @default.
• W3164174591 cites W2072210142 @default.
• W3164174591 cites W2074274706 @default.
• W3164174591 cites W2074378436 @default.
• W3164174591 cites W2084453905 @default.
• W3164174591 cites W2087243986 @default.
• W3164174591 cites W2091159687 @default.
• W3164174591 cites W2096963202 @default.
• W3164174591 cites W2099540110 @default.
• W3164174591 cites W2100837475 @default.
• W3164174591 cites W2115779804 @default.
• W3164174591 cites W2119268123 @default.
• W3164174591 cites W2139496198 @default.
• W3164174591 cites W2161019904 @default.
• W3164174591 cites W2161400520 @default.
• W3164174591 cites W2291563861 @default.
• W3164174591 cites W2298695796 @default.
• W3164174591 cites W2304671403 @default.
• W3164174591 cites W2345745180 @default.
• W3164174591 cites W2615290258 @default.
• W3164174591 cites W2622807556 @default.
• W3164174591 cites W2625911761 @default.
• W3164174591 cites W2729351500 @default.
• W3164174591 cites W2731772702 @default.
• W3164174591 cites W2766400721 @default.
• W3164174591 cites W2774947569 @default.
• W3164174591 cites W2782163737 @default.
• W3164174591 cites W2793877399 @default.
• W3164174591 cites W2800466250 @default.
• W3164174591 cites W2800782157 @default.
• W3164174591 cites W2889474526 @default.
• W3164174591 cites W2891943095 @default.
• W3164174591 cites W2900026479 @default.
• W3164174591 cites W2903517662 @default.
• W3164174591 cites W2916749909 @default.
• W3164174591 cites W2967683178 @default.
• W3164174591 cites W2969940182 @default.
• W3164174591 cites W2979757494 @default.
• W3164174591 cites W3008145942 @default.
• W3164174591 cites W3080368133 @default.
• W3164174591 cites W3085066201 @default.
• W3164174591 cites W3118610300 @default.
• W3164174591 doi "https://doi.org/10.3233/jad-210040" @default.
• W3164174591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8385501" @default.
• W3164174591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34057083" @default.
• W3164174591 hasPublicationYear "2021" @default.
• W3164174591 type Work @default.
• W3164174591 sameAs 3164174591 @default.
• W3164174591 citedByCount "3" @default.
• W3164174591 countsByYear W31641745912021 @default.
• W3164174591 countsByYear W31641745912022 @default.
• W3164174591 countsByYear W31641745912023 @default.
• W3164174591 crossrefType "journal-article" @default.

• next