FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164261748> ?p ?o ?g. }

• W3164261748 abstract "Chlamydia psittaci ( C. psittaci ) is a common zoonotic agent that affects both poultry and humans. Interleukin 10 (IL-10) is an anti-inflammatory factor produced during chlamydial infection, while dendritic cells (DCs) are powerful antigen-presenting cells that induce a primary immune response in the host. However, IL-10 and DCs regulatory mechanisms in C. psittaci infection remain elusive. In vivo and in vitro investigations of the regulatory mechanisms were performed. IL-10 −/− mice, conditional DCs depletion mice (zinc finger dendritic cell-diphtheria toxin receptor [zDC-DTR]), and double-deficient mice (DD, IL-10 −/− /zDC DTR/DTR ) were intranasally infected with C. psittaci . The results showed that more than 90% of IL-10 −/− mice, 70% of wild-type mice, and 60% of double-deficient mice survived, whereas all zDC-DTR mice died. A higher lymphocyte proliferation index was found in the IL-10 inhibitor mice and IL-10 −/− mice. Moreover, severe lesions and high bacterial loads were detected in the zDC-DTR mice compared with double-deficient mice. In vitro studies revealed increased OX40-OX40 ligand (OX40-OX40L) activation and CD4 + T cell proliferation. Besides, the expression of indoleamine 2, 3-dioxygenase (IDO), and regulatory T cells were significantly reduced in the co-culture system of CD4 + T cells and IL-10 −/− DCs in C. psittaci infection. Additionally, the activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome increased to facilitate the apoptosis of DCs, leading to rapid clearance of C. psittaci . Our study showed that IL-10 −/− upregulated the function of deficient DCs by activating OX40-OX40L, T cells, and the NLPR3 inflammasome, and inhibiting IDO, and regulatory T cells. These effects enhanced the survival rate of mice and C. psittaci clearance. Our research highlights the mechanism of IL-10 interaction with DCs, OX40-OX40L, and the NLPR3 inflammasome, as potential targets against C. psittaci infection." @default.
• W3164261748 created "2021-06-07" @default.
• W3164261748 creator A5003980543 @default.
• W3164261748 creator A5013697180 @default.
• W3164261748 creator A5034733517 @default.
• W3164261748 creator A5044891796 @default.
• W3164261748 creator A5068778761 @default.
• W3164261748 creator A5069771802 @default.
• W3164261748 creator A5077361019 @default.
• W3164261748 date "2021-05-21" @default.
• W3164261748 modified "2023-09-26" @default.
• W3164261748 title "IL-10−/− Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways" @default.
• W3164261748 cites W1488485662 @default.
• W3164261748 cites W1511803669 @default.
• W3164261748 cites W1674006573 @default.
• W3164261748 cites W1771469525 @default.
• W3164261748 cites W1936607706 @default.
• W3164261748 cites W1992909270 @default.
• W3164261748 cites W1993070584 @default.
• W3164261748 cites W1998246799 @default.
• W3164261748 cites W2004750182 @default.
• W3164261748 cites W2070103685 @default.
• W3164261748 cites W2078252006 @default.
• W3164261748 cites W2078965027 @default.
• W3164261748 cites W2080933104 @default.
• W3164261748 cites W2089035904 @default.
• W3164261748 cites W2089503694 @default.
• W3164261748 cites W2106240937 @default.
• W3164261748 cites W2118080516 @default.
• W3164261748 cites W2133714264 @default.
• W3164261748 cites W2141214625 @default.
• W3164261748 cites W2151693216 @default.
• W3164261748 cites W2161103261 @default.
• W3164261748 cites W2338809467 @default.
• W3164261748 cites W2472040219 @default.
• W3164261748 cites W2583546598 @default.
• W3164261748 cites W2772866474 @default.
• W3164261748 cites W2790463169 @default.
• W3164261748 cites W2791652972 @default.
• W3164261748 cites W2886032131 @default.
• W3164261748 cites W2920651558 @default.
• W3164261748 cites W2922704064 @default.
• W3164261748 cites W2950869459 @default.
• W3164261748 cites W2953282956 @default.
• W3164261748 cites W2963736543 @default.
• W3164261748 cites W2964001285 @default.
• W3164261748 cites W3007531282 @default.
• W3164261748 cites W3011236945 @default.
• W3164261748 cites W3019008207 @default.
• W3164261748 doi "https://doi.org/10.3389/fimmu.2021.645653" @default.
• W3164261748 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8176032" @default.
• W3164261748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34093535" @default.
• W3164261748 hasPublicationYear "2021" @default.
• W3164261748 type Work @default.
• W3164261748 sameAs 3164261748 @default.
• W3164261748 citedByCount "6" @default.
• W3164261748 countsByYear W31642617482022 @default.
• W3164261748 countsByYear W31642617482023 @default.
• W3164261748 crossrefType "journal-article" @default.
• W3164261748 hasAuthorship W3164261748A5003980543 @default.
• W3164261748 hasAuthorship W3164261748A5013697180 @default.
• W3164261748 hasAuthorship W3164261748A5034733517 @default.
• W3164261748 hasAuthorship W3164261748A5044891796 @default.
• W3164261748 hasAuthorship W3164261748A5068778761 @default.
• W3164261748 hasAuthorship W3164261748A5069771802 @default.
• W3164261748 hasAuthorship W3164261748A5077361019 @default.
• W3164261748 hasBestOaLocation W31642617481 @default.
• W3164261748 hasConcept C203014093 @default.
• W3164261748 hasConcept C2776914184 @default.
• W3164261748 hasConcept C2777209026 @default.
• W3164261748 hasConcept C2777667758 @default.
• W3164261748 hasConcept C2780122209 @default.
• W3164261748 hasConcept C86803240 @default.
• W3164261748 hasConcept C8891405 @default.
• W3164261748 hasConcept C89423630 @default.
• W3164261748 hasConceptScore W3164261748C203014093 @default.
• W3164261748 hasConceptScore W3164261748C2776914184 @default.
• W3164261748 hasConceptScore W3164261748C2777209026 @default.
• W3164261748 hasConceptScore W3164261748C2777667758 @default.
• W3164261748 hasConceptScore W3164261748C2780122209 @default.
• W3164261748 hasConceptScore W3164261748C86803240 @default.
• W3164261748 hasConceptScore W3164261748C8891405 @default.
• W3164261748 hasConceptScore W3164261748C89423630 @default.
• W3164261748 hasFunder F4320326189 @default.
• W3164261748 hasLocation W31642617481 @default.
• W3164261748 hasLocation W31642617482 @default.
• W3164261748 hasOpenAccess W3164261748 @default.
• W3164261748 hasPrimaryLocation W31642617481 @default.
• W3164261748 hasRelatedWork W2056385328 @default.
• W3164261748 hasRelatedWork W2220102944 @default.
• W3164261748 hasRelatedWork W2283896247 @default.
• W3164261748 hasRelatedWork W2410956040 @default.
• W3164261748 hasRelatedWork W2577548098 @default.
• W3164261748 hasRelatedWork W3031852375 @default.
• W3164261748 hasRelatedWork W3112940496 @default.
• W3164261748 hasRelatedWork W3134238239 @default.
• W3164261748 hasRelatedWork W843877257 @default.
• W3164261748 hasRelatedWork W950050067 @default.
• W3164261748 hasVolume "12" @default.
• W3164261748 isParatext "false" @default.

• next