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- W3164274236 endingPage "796" @default.
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- W3164274236 abstract "Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (p = 0.014). A Bayesian regression also including age, gender, hypertension, and virus quantity confirmed that smoking was the most probable risk factor associated with low ACE-2 expression in the model. A direct relation was found between viral quantity and ACE-2 expression (p = 0.028). Finally, high ACE-2 expressors more frequently showed a prevalent pattern of vascular injury than low expressors (p = 0.049). In conclusion, ACE-2 levels were decreased in the lung tissue of smokers with severe COVID-19 pneumonia. These results point out complex biological interactions between SARS-CoV-2 and ACE-2 particularly concerning the aspect of smoking habit and need larger prospective case series and translational studies." @default.
- W3164274236 created "2021-06-07" @default.
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- W3164274236 date "2021-05-26" @default.
- W3164274236 modified "2023-10-18" @default.
- W3164274236 title "Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers With COVID-19Pneumonia" @default.
- W3164274236 cites W1998496562 @default.
- W3164274236 cites W2001788362 @default.
- W3164274236 cites W2029971767 @default.
- W3164274236 cites W2062817591 @default.
- W3164274236 cites W2091671824 @default.
- W3164274236 cites W2116703025 @default.
- W3164274236 cites W2152329221 @default.
- W3164274236 cites W2167384912 @default.
- W3164274236 cites W2331184627 @default.
- W3164274236 cites W2348746475 @default.
- W3164274236 cites W3004280078 @default.
- W3164274236 cites W3007814559 @default.
- W3164274236 cites W3008295344 @default.
- W3164274236 cites W3008827533 @default.
- W3164274236 cites W3009885589 @default.
- W3164274236 cites W3009912996 @default.
- W3164274236 cites W3010538497 @default.
- W3164274236 cites W3011134208 @default.
- W3164274236 cites W3011376519 @default.
- W3164274236 cites W3011483298 @default.
- W3164274236 cites W3011608970 @default.
- W3164274236 cites W3013025026 @default.
- W3164274236 cites W3014604938 @default.
- W3164274236 cites W3015155434 @default.
- W3164274236 cites W3015539298 @default.
- W3164274236 cites W3015660580 @default.
- W3164274236 cites W3015890581 @default.
- W3164274236 cites W3016148207 @default.
- W3164274236 cites W3017841804 @default.
- W3164274236 cites W3017987988 @default.
- W3164274236 cites W3018257933 @default.
- W3164274236 cites W3018448193 @default.
- W3164274236 cites W3020503487 @default.
- W3164274236 cites W3020646040 @default.
- W3164274236 cites W3021329327 @default.
- W3164274236 cites W3021685303 @default.
- W3164274236 cites W3022412356 @default.
- W3164274236 cites W3022971546 @default.
- W3164274236 cites W3024004469 @default.
- W3164274236 cites W3024068183 @default.
- W3164274236 cites W3024339709 @default.
- W3164274236 cites W3024623392 @default.
- W3164274236 cites W3024894164 @default.
- W3164274236 cites W3025847192 @default.
- W3164274236 cites W3027918021 @default.
- W3164274236 cites W3028582054 @default.
- W3164274236 cites W3028583791 @default.
- W3164274236 cites W3030748957 @default.
- W3164274236 cites W3033043516 @default.
- W3164274236 cites W3033716792 @default.
- W3164274236 cites W3035704025 @default.
- W3164274236 cites W3037544553 @default.
- W3164274236 cites W3038741500 @default.
- W3164274236 cites W3040801404 @default.
- W3164274236 cites W3041765132 @default.
- W3164274236 cites W3042292025 @default.
- W3164274236 cites W3043649968 @default.
- W3164274236 cites W3043833747 @default.
- W3164274236 cites W3044069820 @default.
- W3164274236 cites W3044722686 @default.
- W3164274236 cites W3045319552 @default.
- W3164274236 cites W3046281247 @default.
- W3164274236 cites W3048548820 @default.
- W3164274236 cites W3080853025 @default.
- W3164274236 cites W3082704225 @default.
- W3164274236 cites W3087588044 @default.
- W3164274236 cites W3088661180 @default.
- W3164274236 cites W3092361860 @default.
- W3164274236 cites W3092528671 @default.
- W3164274236 cites W3105487129 @default.
- W3164274236 cites W3105736810 @default.
- W3164274236 cites W3108643601 @default.
- W3164274236 cites W3109354304 @default.
- W3164274236 cites W3111104756 @default.
- W3164274236 cites W3112918571 @default.
- W3164274236 cites W3114906536 @default.
- W3164274236 cites W3118927526 @default.
- W3164274236 cites W3120549918 @default.
- W3164274236 cites W3123994040 @default.
- W3164274236 cites W3125160514 @default.