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- W3164279916 abstract "In this chapter, we used cimetidine (C) and cimetidine with malathion (M + C) to assess oxidative stress enzymes suggestive of liver damage in rats exposed to malathion (M) in a subchronic form. Cimetidine is a histamine H2-receptor antagonist that has been demonstrated to inhibit many CYP450 isoforms. Malathion, a commonly used organophosphorus insecticide, causes oxidative liver harm. We studied male Wistar rats weighing 200-250 g, exposed to malathion orally for 3 weeks (0.15 mg / kg /day, 2 mg / kg /day, 15 mg / kg /day) and cimetidine 10 mg / kg /day. Malathion affects susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly. This study will provide alternate clinical diagnoses and therapies for pesticide-induced liver illness, as well as focusing future investigations on oxidative stress in organophosphate-exposed patients and creating intervention techniques." @default.
- W3164279916 created "2021-06-07" @default.
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- W3164279916 date "2021-05-19" @default.
- W3164279916 modified "2023-10-14" @default.
- W3164279916 title "Liver Damage due to the Interaction of Malathion with Cimetidine in Rat: Advanced Study" @default.
- W3164279916 doi "https://doi.org/10.9734/bpi/tipr/v5/9313d" @default.
- W3164279916 hasPublicationYear "2021" @default.
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