FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164305890> ?p ?o ?g. }

• W3164305890 abstract "Abstract Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoiding persistence of dead cells and cellular debris and their consequent effects. Dysregulation of efferocytosis is thought to lead to secondary necrosis and associated inflammation and immune activation. Efferocytosis in primarily murine macrophages and dendritic cells has been shown to require TAM RTKs, with MERTK and AXL being critical for clearance of apoptotic cells. The functional role of human orthologs, especially the exact contribution of each individual receptor is less well studied. Here we show that human macrophages differentiated in vitro from iPSC-derived precursor cells express both AXL and MERTK and engulf apoptotic cells. TAM RTK agonism by the natural ligand growth-arrest specific 6 (GAS6) significantly enhanced such efferocytosis. Using a newly-developed mouse model of kinase-dead MERTK, we demonstrate that MERTK kinase activity is essential for efferocytosis in peritoneal macrophages in vivo. Moreover, human iPSC-derived macrophages treated in vitro with blocking antibodies or small molecule inhibitors recapitulated this observation. Hence, our results highlight a conserved MERTK function between mice and humans, and the critical role of its kinase activity in homeostatic efferocytosis." @default.
• W3164305890 created "2021-06-07" @default.
• W3164305890 creator A5017136656 @default.
• W3164305890 creator A5021595565 @default.
• W3164305890 creator A5021853457 @default.
• W3164305890 creator A5023260904 @default.
• W3164305890 creator A5026774988 @default.
• W3164305890 creator A5028128317 @default.
• W3164305890 creator A5029847792 @default.
• W3164305890 creator A5030279391 @default.
• W3164305890 creator A5035167338 @default.
• W3164305890 creator A5041290954 @default.
• W3164305890 creator A5043442749 @default.
• W3164305890 creator A5043745034 @default.
• W3164305890 creator A5065884985 @default.
• W3164305890 creator A5071786785 @default.
• W3164305890 creator A5073658203 @default.
• W3164305890 creator A5076216504 @default.
• W3164305890 creator A5079934722 @default.
• W3164305890 creator A5082732480 @default.
• W3164305890 creator A5084011990 @default.
• W3164305890 creator A5085075067 @default.
• W3164305890 date "2021-05-25" @default.
• W3164305890 modified "2023-10-16" @default.
• W3164305890 title "Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages" @default.
• W3164305890 cites W1552024435 @default.
• W3164305890 cites W1646925026 @default.
• W3164305890 cites W1971003904 @default.
• W3164305890 cites W1971602395 @default.
• W3164305890 cites W1973431560 @default.
• W3164305890 cites W1988958010 @default.
• W3164305890 cites W1996842103 @default.
• W3164305890 cites W2011617127 @default.
• W3164305890 cites W2020441038 @default.
• W3164305890 cites W2028888447 @default.
• W3164305890 cites W2035500547 @default.
• W3164305890 cites W2036571449 @default.
• W3164305890 cites W2037655090 @default.
• W3164305890 cites W2040434188 @default.
• W3164305890 cites W2043642782 @default.
• W3164305890 cites W2071709107 @default.
• W3164305890 cites W2080677705 @default.
• W3164305890 cites W2081982964 @default.
• W3164305890 cites W2091740140 @default.
• W3164305890 cites W2093633691 @default.
• W3164305890 cites W2100326315 @default.
• W3164305890 cites W2103830724 @default.
• W3164305890 cites W2110153407 @default.
• W3164305890 cites W2118374586 @default.
• W3164305890 cites W2121999038 @default.
• W3164305890 cites W2122693935 @default.
• W3164305890 cites W2123901710 @default.
• W3164305890 cites W2131899060 @default.
• W3164305890 cites W2132626958 @default.
• W3164305890 cites W2134961193 @default.
• W3164305890 cites W2140185229 @default.
• W3164305890 cites W2144741217 @default.
• W3164305890 cites W2149014007 @default.
• W3164305890 cites W2153043340 @default.
• W3164305890 cites W2154049957 @default.
• W3164305890 cites W2333008150 @default.
• W3164305890 cites W2401656403 @default.
• W3164305890 cites W2569227792 @default.
• W3164305890 cites W2623352127 @default.
• W3164305890 cites W2736895630 @default.
• W3164305890 cites W2751767740 @default.
• W3164305890 cites W2781670419 @default.
• W3164305890 cites W2784609274 @default.
• W3164305890 cites W2901171936 @default.
• W3164305890 cites W2995149669 @default.
• W3164305890 cites W2995961563 @default.
• W3164305890 cites W3037615636 @default.
• W3164305890 cites W3039988661 @default.
• W3164305890 doi "https://doi.org/10.1038/s41419-021-03770-0" @default.
• W3164305890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8149813" @default.
• W3164305890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34035216" @default.
• W3164305890 hasPublicationYear "2021" @default.
• W3164305890 type Work @default.
• W3164305890 sameAs 3164305890 @default.
• W3164305890 citedByCount "7" @default.
• W3164305890 countsByYear W31643058902022 @default.
• W3164305890 countsByYear W31643058902023 @default.
• W3164305890 crossrefType "journal-article" @default.
• W3164305890 hasAuthorship W3164305890A5017136656 @default.
• W3164305890 hasAuthorship W3164305890A5021595565 @default.
• W3164305890 hasAuthorship W3164305890A5021853457 @default.
• W3164305890 hasAuthorship W3164305890A5023260904 @default.
• W3164305890 hasAuthorship W3164305890A5026774988 @default.
• W3164305890 hasAuthorship W3164305890A5028128317 @default.
• W3164305890 hasAuthorship W3164305890A5029847792 @default.
• W3164305890 hasAuthorship W3164305890A5030279391 @default.
• W3164305890 hasAuthorship W3164305890A5035167338 @default.
• W3164305890 hasAuthorship W3164305890A5041290954 @default.
• W3164305890 hasAuthorship W3164305890A5043442749 @default.
• W3164305890 hasAuthorship W3164305890A5043745034 @default.
• W3164305890 hasAuthorship W3164305890A5065884985 @default.
• W3164305890 hasAuthorship W3164305890A5071786785 @default.
• W3164305890 hasAuthorship W3164305890A5073658203 @default.
• W3164305890 hasAuthorship W3164305890A5076216504 @default.
• W3164305890 hasAuthorship W3164305890A5079934722 @default.

• next