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- W3164313957 abstract "Abstract Disease overview POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Diagnosis The diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal plasma cell disorder, and at least one of the minor criteria. Risk stratification Because the pathogenesis of the syndrome is not well understood, risk stratification is limited to clinical phenotype rather than specific molecular markers. Risk factors include low serum albumin, age, pleural effusion, pulmonary hypertension, and reduced eGFR. Risk‐adapted therapy For those patients with a dominant plasmacytoma, first line therapy is irradiation. Patients with diffuse sclerotic lesions or disseminated bone marrow involvement and for those who have progression of their disease 3–6 months after completing radiation therapy should receive systemic therapy. Corticosteroids are temporizing, but alkylators are the mainstay of treatment, either in the form of low dose conventional therapy or high dose with stem cell transplantation. Lenalidomide shows promise with manageable toxicity. Thalidomide and bortezomib also have activity, but their benefit needs to be weighed against their risk of exacerbating the peripheral neuropathy. Prompt recognition and institution of both supportive care measures and therapy directed against the plasma cell result in the best outcomes." @default.
- W3164313957 created "2021-06-07" @default.
- W3164313957 creator A5000308170 @default.
- W3164313957 date "2021-05-31" @default.
- W3164313957 modified "2023-10-14" @default.
- W3164313957 title "POEMS syndrome: 2021 Update on diagnosis, risk‐stratification, and management" @default.
- W3164313957 cites W141492214 @default.
- W3164313957 cites W150778959 @default.
- W3164313957 cites W1528918582 @default.
- W3164313957 cites W1834852860 @default.
- W3164313957 cites W185954562 @default.
- W3164313957 cites W1904404356 @default.
- W3164313957 cites W1918173801 @default.
- W3164313957 cites W1963553041 @default.
- W3164313957 cites W1965977684 @default.
- W3164313957 cites W1966714645 @default.
- W3164313957 cites W1966868722 @default.
- W3164313957 cites W1966936495 @default.
- W3164313957 cites W1971290010 @default.
- W3164313957 cites W1971416647 @default.
- W3164313957 cites W1974547871 @default.
- W3164313957 cites W1975521996 @default.
- W3164313957 cites W1975852558 @default.
- W3164313957 cites W1980171506 @default.
- W3164313957 cites W1981313177 @default.
- W3164313957 cites W1982154014 @default.
- W3164313957 cites W1982273340 @default.
- W3164313957 cites W1983182895 @default.
- W3164313957 cites W1986606467 @default.
- W3164313957 cites W1988186308 @default.
- W3164313957 cites W1988461816 @default.
- W3164313957 cites W1988663536 @default.
- W3164313957 cites W1989431331 @default.
- W3164313957 cites W1989698080 @default.
- W3164313957 cites W1991640191 @default.
- W3164313957 cites W1993767416 @default.
- W3164313957 cites W1994771083 @default.
- W3164313957 cites W1995486690 @default.
- W3164313957 cites W1999943742 @default.
- W3164313957 cites W2002085529 @default.
- W3164313957 cites W2004001589 @default.
- W3164313957 cites W2004942346 @default.
- W3164313957 cites W2005800091 @default.
- W3164313957 cites W2013083235 @default.
- W3164313957 cites W2013381973 @default.
- W3164313957 cites W2013802257 @default.
- W3164313957 cites W2015329833 @default.
- W3164313957 cites W2016229037 @default.
- W3164313957 cites W2017240364 @default.
- W3164313957 cites W2021101080 @default.
- W3164313957 cites W2024554365 @default.
- W3164313957 cites W2026920764 @default.
- W3164313957 cites W2027488164 @default.
- W3164313957 cites W2027742754 @default.
- W3164313957 cites W2027879458 @default.
- W3164313957 cites W2032048924 @default.
- W3164313957 cites W2033178897 @default.
- W3164313957 cites W2033869363 @default.
- W3164313957 cites W2034798596 @default.
- W3164313957 cites W2035834427 @default.
- W3164313957 cites W2038193784 @default.
- W3164313957 cites W2039471716 @default.
- W3164313957 cites W2039717141 @default.
- W3164313957 cites W2039724386 @default.
- W3164313957 cites W2040057687 @default.
- W3164313957 cites W2040978620 @default.
- W3164313957 cites W2041952262 @default.
- W3164313957 cites W2042028969 @default.
- W3164313957 cites W2042765702 @default.
- W3164313957 cites W2043503880 @default.
- W3164313957 cites W2044439644 @default.
- W3164313957 cites W2046840192 @default.
- W3164313957 cites W2049043216 @default.
- W3164313957 cites W2050080528 @default.
- W3164313957 cites W2051556891 @default.
- W3164313957 cites W2052565014 @default.
- W3164313957 cites W2053289260 @default.
- W3164313957 cites W2054888616 @default.
- W3164313957 cites W2055500870 @default.
- W3164313957 cites W2055563816 @default.
- W3164313957 cites W2055979425 @default.
- W3164313957 cites W2059269328 @default.
- W3164313957 cites W2059736302 @default.
- W3164313957 cites W2059782906 @default.
- W3164313957 cites W2061108137 @default.
- W3164313957 cites W2061738284 @default.
- W3164313957 cites W2063493287 @default.
- W3164313957 cites W2063886936 @default.
- W3164313957 cites W2064281577 @default.
- W3164313957 cites W2064346179 @default.
- W3164313957 cites W2064829641 @default.
- W3164313957 cites W2064944325 @default.
- W3164313957 cites W2066743269 @default.
- W3164313957 cites W2066994535 @default.
- W3164313957 cites W2067519094 @default.
- W3164313957 cites W2070530010 @default.
- W3164313957 cites W2073008290 @default.
- W3164313957 cites W2073427257 @default.