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- W3164323000 endingPage "933" @default.
- W3164323000 startingPage "918" @default.
- W3164323000 abstract "The efficiency of somatic cell nuclear transfer (scNT) for production of viable offspring is relatively low as compared to in vitro fertilization (IVF), presumably due to deficiencies in epigenetic reprogramming of the donor cell genome. Such defects may also involve the population of small non-coding RNAs (sncRNAs), which are important during early embryonic development. The objective of this study was to examine dynamic changes in relative abundance of sncRNAs during the maternal-to-embryonic transition (MET) in bovine embryos produced by scNT as compared to IVF by using RNA sequencing. When comparing populations of miRNA in scNT versus IVF embryos, only miR-2340, miR-345, and miR34a were differentially expressed in morulae, though many more miRNAs were differentially expressed when comparing across developmental stages. Also of interest, distinct populations of piwi-interacting like RNAs (pilRNAs) were identified in bovine embryos prior to and during embryonic genome activation (EGA) as compared bovine embryos post-EGA and differentiated cells. Overall, sncRNA sequencing analysis of preimplantation embryos revealed largely similar profiles of sncRNAs for IVF and scNT embryos at the 2-cell, 8-cell, morula, and blastocyst stages of development. However, these sncRNA profiles, including miRNA, piRNA, and tRNA fragments, were notably distinct prior to and after completion of the MET." @default.
- W3164323000 created "2021-06-07" @default.
- W3164323000 creator A5007909705 @default.
- W3164323000 creator A5026776123 @default.
- W3164323000 creator A5038107522 @default.
- W3164323000 creator A5042562433 @default.
- W3164323000 creator A5054883946 @default.
- W3164323000 creator A5091433180 @default.
- W3164323000 date "2021-05-03" @default.
- W3164323000 modified "2023-10-15" @default.
- W3164323000 title "Dynamics of small non-coding RNAs in bovine scNT embryos through the maternal-to-embryonic transition" @default.
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- W3164323000 doi "https://doi.org/10.1093/biolre/ioab107" @default.