Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164323882> ?p ?o ?g. }
- W3164323882 endingPage "641" @default.
- W3164323882 startingPage "632" @default.
- W3164323882 abstract "Oxygen supplementation is one of the most common interventions in critically ill patients. Despite over a century of data suggesting both beneficial and detrimental effects of supplemental oxygen, optimal arterial oxygenation targets in adult patients remain unclear. Laboratory animal studies have consistently showed that exposure to a high FiO2 causes respiratory failure and early death. Human autopsy studies from the 1960s purported to provide histologic evidence of pulmonary oxygen toxicity in the form of diffuse alveolar damage. However, concomitant ventilator-induced lung injury and/or other causes of acute lung injury may explain these findings. Although some observational studies in general populations of critically adults showed higher mortality in association with higher oxygen exposures, this finding has not been consistent. For some specific populations, such as those with cardiac arrest, studies have suggested harm from targeting supraphysiologic PaO2 levels. More recently, randomized clinical trials of arterial oxygenation targets in narrower physiologic ranges were conducted in critically ill adult patients. Although two smaller trials came to opposite conclusions, the two largest of these trials showed no differences in clinical outcomes in study groups that received conservative versus liberal oxygen targets, suggesting that either strategy is reasonable. It is possible that some strategies are of benefit in some subpopulations, and this remains an important ongoing area of research. Because of the ubiquity of oxygen supplementation in critically ill adults, even small treatment effects could have a large impact on a global scale." @default.
- W3164323882 created "2021-06-07" @default.
- W3164323882 creator A5016346905 @default.
- W3164323882 creator A5027388050 @default.
- W3164323882 creator A5036048318 @default.
- W3164323882 date "2021-09-15" @default.
- W3164323882 modified "2023-10-06" @default.
- W3164323882 title "Oxygen Toxicity in Critically Ill Adults" @default.
- W3164323882 cites W1525938916 @default.
- W3164323882 cites W1914024450 @default.
- W3164323882 cites W1928918188 @default.
- W3164323882 cites W1938846285 @default.
- W3164323882 cites W1963595029 @default.
- W3164323882 cites W1963643838 @default.
- W3164323882 cites W1975333034 @default.
- W3164323882 cites W1981287061 @default.
- W3164323882 cites W2003049295 @default.
- W3164323882 cites W2008356609 @default.
- W3164323882 cites W2011404989 @default.
- W3164323882 cites W2012627045 @default.
- W3164323882 cites W2018138692 @default.
- W3164323882 cites W2028827931 @default.
- W3164323882 cites W2038508950 @default.
- W3164323882 cites W2042386901 @default.
- W3164323882 cites W2052703499 @default.
- W3164323882 cites W2070017721 @default.
- W3164323882 cites W2071853044 @default.
- W3164323882 cites W2076257350 @default.
- W3164323882 cites W208036677 @default.
- W3164323882 cites W2101436344 @default.
- W3164323882 cites W2107262953 @default.
- W3164323882 cites W2107497425 @default.
- W3164323882 cites W2110625603 @default.
- W3164323882 cites W2123193214 @default.
- W3164323882 cites W2128862148 @default.
- W3164323882 cites W2131225160 @default.
- W3164323882 cites W2134067436 @default.
- W3164323882 cites W2137878737 @default.
- W3164323882 cites W2138667236 @default.
- W3164323882 cites W2146682756 @default.
- W3164323882 cites W2147934896 @default.
- W3164323882 cites W2150455735 @default.
- W3164323882 cites W2150792876 @default.
- W3164323882 cites W2151546237 @default.
- W3164323882 cites W2163104804 @default.
- W3164323882 cites W2170118968 @default.
- W3164323882 cites W2171516150 @default.
- W3164323882 cites W2188088995 @default.
- W3164323882 cites W2210128369 @default.
- W3164323882 cites W2235701907 @default.
- W3164323882 cites W2280170445 @default.
- W3164323882 cites W2324626880 @default.
- W3164323882 cites W2329391602 @default.
- W3164323882 cites W2335230165 @default.
- W3164323882 cites W2395755052 @default.
- W3164323882 cites W2409979800 @default.
- W3164323882 cites W2410199588 @default.
- W3164323882 cites W2493756966 @default.
- W3164323882 cites W2528556615 @default.
- W3164323882 cites W2532550607 @default.
- W3164323882 cites W2587881246 @default.
- W3164323882 cites W2594294830 @default.
- W3164323882 cites W2747404832 @default.
- W3164323882 cites W2755788236 @default.
- W3164323882 cites W2772166052 @default.
- W3164323882 cites W2779793883 @default.
- W3164323882 cites W2788801492 @default.
- W3164323882 cites W2801508025 @default.
- W3164323882 cites W2883638038 @default.
- W3164323882 cites W2889649899 @default.
- W3164323882 cites W2889778156 @default.
- W3164323882 cites W2898599437 @default.
- W3164323882 cites W289877619 @default.
- W3164323882 cites W2915126954 @default.
- W3164323882 cites W2972862987 @default.
- W3164323882 cites W2977278846 @default.
- W3164323882 cites W2979851589 @default.
- W3164323882 cites W2980403271 @default.
- W3164323882 cites W2990625389 @default.
- W3164323882 cites W3005325972 @default.
- W3164323882 cites W3011047309 @default.
- W3164323882 cites W3015168464 @default.
- W3164323882 cites W3037831724 @default.
- W3164323882 cites W3041432730 @default.
- W3164323882 cites W3043492626 @default.
- W3164323882 cites W3048766942 @default.
- W3164323882 cites W3092839682 @default.
- W3164323882 cites W3121451006 @default.
- W3164323882 cites W3134595848 @default.
- W3164323882 cites W331399997 @default.
- W3164323882 doi "https://doi.org/10.1164/rccm.202102-0417ci" @default.
- W3164323882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8521700" @default.
- W3164323882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34086536" @default.
- W3164323882 hasPublicationYear "2021" @default.
- W3164323882 type Work @default.
- W3164323882 sameAs 3164323882 @default.
- W3164323882 citedByCount "20" @default.
- W3164323882 countsByYear W31643238822021 @default.