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• W3164328883 abstract "Chemopreventive approaches with food-derived phytochemicals are progressively rising as a significant aspect of tumor management and control. Herein, we have showcased the major phytoconstituents belonging to the group of flavanoid, as anti-cancer agents used for the treatment and prevention of hepatocellular carcinoma (HCC). Sorafenib is the sole drug used for the treatment of advanced HCC, but its clinical application is limited because of its severe adverse effects and drug resistance. Diet-based chemoprevention seems to be the way forward for this disease of malignant nature. As HCC is derived from a chronic inflammatory milieu, the regular incorporation of bioactive phytochemicals in the diet will confer protection and prevent progression to hepatocarcinogenesis. Many preclinical studies proved that the health benefits of flavonoids confer cytotoxic potential against various types of cancers including hepatocellular carcinoma. As flavonoids with excellent safety profile are abundantly present in common vegetables and fruits, they can be better utilized for chemoprevention and chemosensitization in such chronic condition. This review highlights the plausible role of the eight most promising flavonoids (Curcumin, Kaempferol, Resveratrol, Quercetin, Silibinin, Baicalein, Galangin and Luteolin) as key orchestrators of chemoprevention in hepatocellular carcinoma with preclinical and clinical evidence. An attempt to address the challenges in its clinical translation is also included. This review also provides an insight into the close association of HCC and metabolic disorders which may further decipher the chemopreventive effect of dietary bioactive from a proof of concept to extensive clinical translation. Practical applications According to GLOBOCAN 2020 database, it is estimated that 905,677 new cases of liver cancer and approximately 830,180 deaths related to that. The cancer incidence and mortality are almost similar as it is diagnosed at an advanced stage in patients where systemic drug therapy is the sole approach. Due to the emergence of multidrug resistance and drug-related toxicities, most of the patient can not adhere to the therapy regimen. Flavonoids are known to be a potential anticancer agent with an excellent safety profile. These are found to be effective preclinically against hepatocellular carcinoma through modulation of numerous pathways in hepatocarcinogenesis. But, the bioavailability issue, lack of well designed-validated clinical evidence, the possibility of food–drug interaction etc limit its clinical utility. The research inputs mainly to overcome pharmacokinetic issues along with suitable validation of efficacy and toxicity will be a critical point for establishing flavonoids as an effective, safe, affordable therapeutics." @default.
• W3164328883 created "2021-06-07" @default.
• W3164328883 creator A5000254483 @default.
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• W3164328883 creator A5037122426 @default.
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• W3164328883 creator A5079050135 @default.
• W3164328883 date "2021-05-24" @default.
• W3164328883 modified "2023-10-14" @default.
• W3164328883 title "Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review" @default.
• W3164328883 cites W1138555338 @default.
• W3164328883 cites W1235120122 @default.
• W3164328883 cites W1484007224 @default.
• W3164328883 cites W1486720764 @default.
• W3164328883 cites W1551499428 @default.
• W3164328883 cites W1900973879 @default.
• W3164328883 cites W1914622032 @default.
• W3164328883 cites W1917820844 @default.
• W3164328883 cites W1921220968 @default.
• W3164328883 cites W1964351891 @default.
• W3164328883 cites W1964983873 @default.
• W3164328883 cites W1974197340 @default.
• W3164328883 cites W1976271889 @default.
• W3164328883 cites W1977515048 @default.
• W3164328883 cites W1979047182 @default.
• W3164328883 cites W1980060783 @default.
• W3164328883 cites W1981239378 @default.
• W3164328883 cites W1987340528 @default.
• W3164328883 cites W1990980729 @default.
• W3164328883 cites W2007299371 @default.
• W3164328883 cites W2007727330 @default.
• W3164328883 cites W2009924034 @default.
• W3164328883 cites W2012077091 @default.
• W3164328883 cites W2013837271 @default.
• W3164328883 cites W2016358101 @default.
• W3164328883 cites W2016372364 @default.
• W3164328883 cites W2018195061 @default.
• W3164328883 cites W2019166464 @default.
• W3164328883 cites W2024791268 @default.
• W3164328883 cites W2028272823 @default.
• W3164328883 cites W2029776483 @default.
• W3164328883 cites W2033218392 @default.
• W3164328883 cites W2035499134 @default.
• W3164328883 cites W2039261753 @default.
• W3164328883 cites W2039507504 @default.
• W3164328883 cites W2041950852 @default.
• W3164328883 cites W2044496118 @default.
• W3164328883 cites W2044787665 @default.
• W3164328883 cites W2044913906 @default.
• W3164328883 cites W2045146500 @default.
• W3164328883 cites W2045970460 @default.
• W3164328883 cites W2048923609 @default.
• W3164328883 cites W2050244937 @default.
• W3164328883 cites W2050837407 @default.
• W3164328883 cites W2052469687 @default.
• W3164328883 cites W2054206661 @default.
• W3164328883 cites W2057520467 @default.
• W3164328883 cites W2063299574 @default.
• W3164328883 cites W2067670322 @default.
• W3164328883 cites W2072490844 @default.
• W3164328883 cites W2073171043 @default.
• W3164328883 cites W2074383379 @default.
• W3164328883 cites W2076920401 @default.
• W3164328883 cites W2080304600 @default.
• W3164328883 cites W2081401587 @default.
• W3164328883 cites W2085075365 @default.
• W3164328883 cites W2088849513 @default.
• W3164328883 cites W2095426065 @default.
• W3164328883 cites W2097360999 @default.
• W3164328883 cites W2098049360 @default.
• W3164328883 cites W2099215442 @default.
• W3164328883 cites W2100798947 @default.
• W3164328883 cites W2107269155 @default.
• W3164328883 cites W2109219853 @default.
• W3164328883 cites W2129710639 @default.
• W3164328883 cites W2132637443 @default.
• W3164328883 cites W2133848791 @default.
• W3164328883 cites W2135736941 @default.
• W3164328883 cites W2136402236 @default.
• W3164328883 cites W2138843776 @default.
• W3164328883 cites W2139210816 @default.
• W3164328883 cites W2139240475 @default.
• W3164328883 cites W2140813472 @default.
• W3164328883 cites W2141977119 @default.
• W3164328883 cites W2143626453 @default.
• W3164328883 cites W2144862608 @default.
• W3164328883 cites W2144868623 @default.
• W3164328883 cites W2154193667 @default.
• W3164328883 cites W2155098460 @default.
• W3164328883 cites W2160901639 @default.
• W3164328883 cites W2162149845 @default.
• W3164328883 cites W2162676285 @default.
• W3164328883 cites W2168556140 @default.
• W3164328883 cites W2170028652 @default.
• W3164328883 cites W2171371398 @default.
• W3164328883 cites W2196397027 @default.
• W3164328883 cites W2227736936 @default.
• W3164328883 cites W2297606889 @default.

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