FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164331335> ?p ?o ?g. }

• W3164331335 endingPage "707" @default.
• W3164331335 startingPage "706" @default.
• W3164331335 abstract "Background: Current studies suggest that the phenotype of spondyloarthritis differs between genders and that this may influence the subsequent diagnostic approach and therapeutic decisions 1 . The German non-interventional study AQUILA provides real-world data on the influence of gender on therapeutic effectiveness and retention rate under treatment with secukinumab, a fully human monoclonal antibody that selectively inhibits interleukin-17A. Objectives: The aim of this interim analysis is to describe selected baseline (BL) demographics, to evaluate secukinumab treatment outcomes on disease activity, global functioning and health and retention rate depending on the gender of AS patients. Methods: AQUILA is an ongoing, multi-center, non-interventional study including more than 3000 patients with active AS or psoriatic arthritis. Patients were observed from BL up to week (w) 52 according to clinical routine. Real-world data was assessed prospectively and analyzed as observed. Validated questionnaires were used to collect data on disease activity (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI), global functioning and health (Assessment of SpondyloArthritis-Health Index, ASAS-HI) and severity of depressive mood (Beck´s Depression Inventory version II, BDI-II). Patient reported outcomes were reported using patient´s global assessment (PGA). In addition, retention rates (time from study inclusion until premature secukinumab treatment discontinuation) were assessed through Kaplan-Meier plots. This interim analysis focuses on the subgroups of male and female AS patients. Results: At BL, 683 AS patients were included: 59.7% (n=408) male and 40.3% (n=275) female. Demographic data (Table 1) of male and female AS patients differed numerically in the following parameters: proportion of obese patients, smokers, pretreatment with disease-modifying antirheumatic drugs (csDMARDs), and biologicals/biosimilars (b-bsDMARDs). Mean BASDAI and PGA were comparable between male and female AS patients over time (♂: 5.2 at BL to 3.8 at w52, ♀: 5.3 at BL to 4.1 at w52 and ♂: 5.9 at BL to 4.1 at w52, ♀: 5.6 at BL to 4.3 at w52, respectively). Mean ASAS-HI over time was higher in women; nevertheless, improvements in global functioning were comparable for both genders from BL to week 52 (Fig. 1A). Severity of depressive mood was numerically lower in male patients; nevertheless, BDI-II reductions were comparable across the genders (♂: 11.2 at BL to 10.0 at w52, ♀: 13.1 at BL to 11.0 at w52). Secukinumab treatment retention rate for men was (not significantly) higher than for women (Fig. 1B). Conclusion: In a real-world setting, secukinumab improved disease activity, global functioning and severity of depressive mood in AS patients in both men and women. Women showed overall higher disease burden. Altogether, real-world data of this interim analysis are in line with those of Phase 3 studies and show that secukinumab is an effective treatment up to 52 weeks with high treatment retention rates, irrespective of gender. References: [1]Landi, M. , et al. Medicine (Baltimore ) 95 , e5652 (2016). Table 1. Overview of baseline characteristics in AS patients depending on gender Demographics* Male (N=408 ) Female (N=275 ) Age, years 45.6 (12.1) 47.8 (12.2) BMI, kg/m 2 27.4 (4.5) 27.6 (5.7) BMI >25 to ≤30 kg/m 2 , n (%) 178 (45.1) 88 (32.4) BMI >30 kg/m 2 , n (%) 94 (23.8) 83 (30.5) Smoker, n (%) 150 (36.8) 67 (24.4) BASDAI 5.2 (1.9) 5.3 (1.9) PGA 5.8 (4.9) 5.6 (5.6) ASAS-HI 7.4 (3.5) 8.2 (3.5) BDI-II 11.2 (10.2) 13.1 (13.0) Medication prior to secukinumab initiation, n (%): NSAID 330 (80.9) 222 (80.7) csDMARD 145 (35.5) 137 (49.8) b-bsDMARD 249 (61.0) 190 (69.1) *variables given as mean (SD) Figure 1. Global functioning and secukinumab treatment retention in AS patients stratified by gender Note: P-values are of exploratory nature Disclosure of Interests: Uta Kiltz Consultant of: AbbVie, Biocad, Chugai, Eli Lilly, Gruenenthal, Janssen, MSD, Novartis, Pfizer, Roche, UCB, Grant/research support from: AbbVie, Biogen, Novartis, Pfizer, Jan Brandt-Juergens Consultant of: Abbvie, Affibody, BMS, Gilead, Janssen, Lilly, Medac, MSD, Novartis, Pfizer, Roche, Sanofi-Aventis, UCB, Peter Kästner Consultant of: Chugai, Novartis, Elke Riechers Consultant of: AbbVie, Chugai, Novartis, UCB, Grant/research support from: AbbVie, Chugai, Lilly, Janssen, Novartis, Pfizer, Roche, UCB, Daniel Peterlik Employee of: Novartis Pharma GmbH, Hans-Peter Tony Consultant of: AbbVie, Astra-Zeneca, BMS, Chugai, Janssen, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi" @default.
• W3164331335 created "2021-06-07" @default.
• W3164331335 creator A5001947020 @default.
• W3164331335 creator A5058930849 @default.
• W3164331335 creator A5060626069 @default.
• W3164331335 creator A5064219689 @default.
• W3164331335 creator A5068820873 @default.
• W3164331335 creator A5074627741 @default.
• W3164331335 date "2021-05-19" @default.
• W3164331335 modified "2023-09-25" @default.
• W3164331335 title "POS0899 HOW DOES GENDER AFFECT SECUKINUMAB TREATMENT OUTCOMES AND RETENTION RATES IN PATIENTS WITH ANKYLOSING SPONDYLITIS? - REAL WORLD DATA FROM THE GERMAN AQUILA STUDY" @default.
• W3164331335 doi "https://doi.org/10.1136/annrheumdis-2021-eular.141" @default.
• W3164331335 hasPublicationYear "2021" @default.
• W3164331335 type Work @default.
• W3164331335 sameAs 3164331335 @default.
• W3164331335 citedByCount "2" @default.
• W3164331335 countsByYear W31643313352023 @default.
• W3164331335 crossrefType "journal-article" @default.
• W3164331335 hasAuthorship W3164331335A5001947020 @default.
• W3164331335 hasAuthorship W3164331335A5058930849 @default.
• W3164331335 hasAuthorship W3164331335A5060626069 @default.
• W3164331335 hasAuthorship W3164331335A5064219689 @default.
• W3164331335 hasAuthorship W3164331335A5068820873 @default.
• W3164331335 hasAuthorship W3164331335A5074627741 @default.
• W3164331335 hasBestOaLocation W31643313351 @default.
• W3164331335 hasConcept C118552586 @default.
• W3164331335 hasConcept C126322002 @default.
• W3164331335 hasConcept C1862650 @default.
• W3164331335 hasConcept C2776260265 @default.
• W3164331335 hasConcept C2777402515 @default.
• W3164331335 hasConcept C2777453003 @default.
• W3164331335 hasConcept C2777575956 @default.
• W3164331335 hasConcept C2778715236 @default.
• W3164331335 hasConcept C2779631380 @default.
• W3164331335 hasConcept C2779786854 @default.
• W3164331335 hasConcept C558461103 @default.
• W3164331335 hasConcept C71924100 @default.
• W3164331335 hasConceptScore W3164331335C118552586 @default.
• W3164331335 hasConceptScore W3164331335C126322002 @default.
• W3164331335 hasConceptScore W3164331335C1862650 @default.
• W3164331335 hasConceptScore W3164331335C2776260265 @default.
• W3164331335 hasConceptScore W3164331335C2777402515 @default.
• W3164331335 hasConceptScore W3164331335C2777453003 @default.
• W3164331335 hasConceptScore W3164331335C2777575956 @default.
• W3164331335 hasConceptScore W3164331335C2778715236 @default.
• W3164331335 hasConceptScore W3164331335C2779631380 @default.
• W3164331335 hasConceptScore W3164331335C2779786854 @default.
• W3164331335 hasConceptScore W3164331335C558461103 @default.
• W3164331335 hasConceptScore W3164331335C71924100 @default.
• W3164331335 hasIssue "Suppl 1" @default.
• W3164331335 hasLocation W31643313351 @default.
• W3164331335 hasOpenAccess W3164331335 @default.
• W3164331335 hasPrimaryLocation W31643313351 @default.
• W3164331335 hasRelatedWork W2111965497 @default.
• W3164331335 hasRelatedWork W2416448965 @default.
• W3164331335 hasRelatedWork W2946910872 @default.
• W3164331335 hasRelatedWork W2952285305 @default.
• W3164331335 hasRelatedWork W3157181858 @default.
• W3164331335 hasRelatedWork W3164331335 @default.
• W3164331335 hasRelatedWork W4224317126 @default.
• W3164331335 hasRelatedWork W4246832057 @default.
• W3164331335 hasRelatedWork W4283692022 @default.
• W3164331335 hasRelatedWork W4293229883 @default.
• W3164331335 hasVolume "80" @default.
• W3164331335 isParatext "false" @default.
• W3164331335 isRetracted "false" @default.
• W3164331335 magId "3164331335" @default.
• W3164331335 workType "article" @default.