Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164338992> ?p ?o ?g. }
- W3164338992 endingPage "2170" @default.
- W3164338992 startingPage "2161" @default.
- W3164338992 abstract "KMRC011 is a novel Toll-like receptor 5 agonist under development as a treatment for acute radiation syndrome (ARS). The aim of this first-in-human study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of a single intramuscular dose of KMRC011 in healthy subjects. A randomized, single-blind, placebo-controlled, single dose-escalation study was conducted with the starting dose of 5 μg. Eight (4 only for 5 μg cohort) subjects per cohort were randomly assigned to KMRC011 or placebo in a 3:1 ratio. Dose-limiting toxicity (DLT) was assessed throughout the study. Serum concentrations of KMRC011, granulocyte colony-stimulating factor (G-CSF), and interleukin-6 (IL-6) were measured up to 48 h postdose. Based on safety review, the dose of KMRC011 escalated up to 20 μg, and consequently, a total of 4 dose levels (5, 10, 15, and 20 μg) were explored. The most common adverse event was injection site reaction, showing no dose-related trend. Three DLTs (2 cases of hepatic enzyme increased and 1 of pyrexia) were observed; 1 in the 15 μg cohort and 2 in the 20 μg cohort. A developed method could not detect any KMRC011 in serum. KMRC011 15 μg and 20 μg showed significant increases of G-CSF, IL-6, and absolute neutrophil counts, compared with the placebo. A single intramuscular administration of KMRC011 ranging from 5 to 15 μg was tolerated in healthy subjects. Doses of KMRC011 equal to or greater than 15 μg exerted TLR5 agonist-like activities by increasing serum G-CSF and IL-6. It suggests that KMRC011 has the potential for a treatment for ARS." @default.
- W3164338992 created "2021-06-07" @default.
- W3164338992 creator A5018073941 @default.
- W3164338992 creator A5026723153 @default.
- W3164338992 creator A5027989015 @default.
- W3164338992 creator A5028454019 @default.
- W3164338992 creator A5038976110 @default.
- W3164338992 creator A5040721205 @default.
- W3164338992 creator A5057662102 @default.
- W3164338992 creator A5079416565 @default.
- W3164338992 date "2021-06-10" @default.
- W3164338992 modified "2023-10-16" @default.
- W3164338992 title "A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics" @default.
- W3164338992 cites W136190643 @default.
- W3164338992 cites W1547679482 @default.
- W3164338992 cites W2013040905 @default.
- W3164338992 cites W2033575211 @default.
- W3164338992 cites W2044351980 @default.
- W3164338992 cites W2057858743 @default.
- W3164338992 cites W2105192616 @default.
- W3164338992 cites W2107674270 @default.
- W3164338992 cites W2114964734 @default.
- W3164338992 cites W2118796952 @default.
- W3164338992 cites W2155398159 @default.
- W3164338992 cites W2257942969 @default.
- W3164338992 cites W2471732223 @default.
- W3164338992 cites W2680883357 @default.
- W3164338992 cites W2735527928 @default.
- W3164338992 cites W2768536814 @default.
- W3164338992 cites W2808166290 @default.
- W3164338992 cites W2901411178 @default.
- W3164338992 cites W2902130031 @default.
- W3164338992 cites W2917403768 @default.
- W3164338992 cites W2941603842 @default.
- W3164338992 cites W2944795429 @default.
- W3164338992 cites W2944798097 @default.
- W3164338992 cites W2963953774 @default.
- W3164338992 cites W3004744640 @default.
- W3164338992 cites W47829030 @default.
- W3164338992 doi "https://doi.org/10.1111/cts.13073" @default.
- W3164338992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8604209" @default.
- W3164338992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34080313" @default.
- W3164338992 hasPublicationYear "2021" @default.
- W3164338992 type Work @default.
- W3164338992 sameAs 3164338992 @default.
- W3164338992 citedByCount "3" @default.
- W3164338992 countsByYear W31643389922022 @default.
- W3164338992 countsByYear W31643389922023 @default.
- W3164338992 crossrefType "journal-article" @default.
- W3164338992 hasAuthorship W3164338992A5018073941 @default.
- W3164338992 hasAuthorship W3164338992A5026723153 @default.
- W3164338992 hasAuthorship W3164338992A5027989015 @default.
- W3164338992 hasAuthorship W3164338992A5028454019 @default.
- W3164338992 hasAuthorship W3164338992A5038976110 @default.
- W3164338992 hasAuthorship W3164338992A5040721205 @default.
- W3164338992 hasAuthorship W3164338992A5057662102 @default.
- W3164338992 hasAuthorship W3164338992A5079416565 @default.
- W3164338992 hasBestOaLocation W31643389923 @default.
- W3164338992 hasConcept C111113717 @default.
- W3164338992 hasConcept C112705442 @default.
- W3164338992 hasConcept C126322002 @default.
- W3164338992 hasConcept C142724271 @default.
- W3164338992 hasConcept C170493617 @default.
- W3164338992 hasConcept C197934379 @default.
- W3164338992 hasConcept C204787440 @default.
- W3164338992 hasConcept C27081682 @default.
- W3164338992 hasConcept C2776694085 @default.
- W3164338992 hasConcept C2777767877 @default.
- W3164338992 hasConcept C2778375690 @default.
- W3164338992 hasConcept C2778938600 @default.
- W3164338992 hasConcept C71924100 @default.
- W3164338992 hasConcept C72563966 @default.
- W3164338992 hasConcept C90924648 @default.
- W3164338992 hasConcept C98274493 @default.
- W3164338992 hasConceptScore W3164338992C111113717 @default.
- W3164338992 hasConceptScore W3164338992C112705442 @default.
- W3164338992 hasConceptScore W3164338992C126322002 @default.
- W3164338992 hasConceptScore W3164338992C142724271 @default.
- W3164338992 hasConceptScore W3164338992C170493617 @default.
- W3164338992 hasConceptScore W3164338992C197934379 @default.
- W3164338992 hasConceptScore W3164338992C204787440 @default.
- W3164338992 hasConceptScore W3164338992C27081682 @default.
- W3164338992 hasConceptScore W3164338992C2776694085 @default.
- W3164338992 hasConceptScore W3164338992C2777767877 @default.
- W3164338992 hasConceptScore W3164338992C2778375690 @default.
- W3164338992 hasConceptScore W3164338992C2778938600 @default.
- W3164338992 hasConceptScore W3164338992C71924100 @default.
- W3164338992 hasConceptScore W3164338992C72563966 @default.
- W3164338992 hasConceptScore W3164338992C90924648 @default.
- W3164338992 hasConceptScore W3164338992C98274493 @default.
- W3164338992 hasIssue "6" @default.
- W3164338992 hasLocation W31643389921 @default.
- W3164338992 hasLocation W31643389922 @default.
- W3164338992 hasLocation W31643389923 @default.
- W3164338992 hasLocation W31643389924 @default.
- W3164338992 hasOpenAccess W3164338992 @default.
- W3164338992 hasPrimaryLocation W31643389921 @default.
- W3164338992 hasRelatedWork W1830687917 @default.