Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164349968> ?p ?o ?g. }
- W3164349968 endingPage "20210577" @default.
- W3164349968 startingPage "20210577" @default.
- W3164349968 abstract "Tasmanian devils ( Sarcophilus harrisii ) are evolving in response to a unique transmissible cancer, devil facial tumour disease (DFTD), first described in 1996. Persistence of wild populations and the recent emergence of a second independently evolved transmissible cancer suggest that transmissible cancers may be a recurrent feature in devils. Here, we compared signatures of selection across temporal scales to determine whether genes or gene pathways under contemporary selection (six to eight generations) have also been subject to historical selection (65–85 Myr). First, we used targeted sequencing, RAD-capture, in approximately 2500 devils in six populations to identify genomic regions subject to rapid evolution. We documented genome-wide contemporary evolution, including 186 candidate genes related to cell cycling and immune response. Then we used a molecular evolution approach to identify historical positive selection in devils compared to other marsupials and found evidence of selection in 1773 genes. However, we found limited overlap across time scales, with only 16 shared candidate genes, and no overlap in enriched functional gene sets. Our results are consistent with a novel, multi-locus evolutionary response of devils to DFTD. Our results can inform conservation by identifying high priority targets for genetic monitoring and guiding maintenance of adaptive potential in managed populations." @default.
- W3164349968 created "2021-06-07" @default.
- W3164349968 creator A5000681981 @default.
- W3164349968 creator A5011557413 @default.
- W3164349968 creator A5023481235 @default.
- W3164349968 creator A5026382424 @default.
- W3164349968 creator A5030758481 @default.
- W3164349968 creator A5032967781 @default.
- W3164349968 creator A5034164465 @default.
- W3164349968 creator A5047244631 @default.
- W3164349968 creator A5072773773 @default.
- W3164349968 creator A5074009978 @default.
- W3164349968 creator A5079923400 @default.
- W3164349968 creator A5083039744 @default.
- W3164349968 creator A5083710430 @default.
- W3164349968 creator A5084824186 @default.
- W3164349968 date "2021-05-26" @default.
- W3164349968 modified "2023-10-15" @default.
- W3164349968 title "Contemporary and historical selection in Tasmanian devils ( <i>Sarcophilus harrisii</i> ) support novel, polygenic response to transmissible cancer" @default.
- W3164349968 cites W126684448 @default.
- W3164349968 cites W1582217180 @default.
- W3164349968 cites W1907579575 @default.
- W3164349968 cites W1935879369 @default.
- W3164349968 cites W1966546969 @default.
- W3164349968 cites W1970812281 @default.
- W3164349968 cites W1981770389 @default.
- W3164349968 cites W1987510089 @default.
- W3164349968 cites W1993452367 @default.
- W3164349968 cites W2005785944 @default.
- W3164349968 cites W2034329979 @default.
- W3164349968 cites W2036589180 @default.
- W3164349968 cites W2046862684 @default.
- W3164349968 cites W2048069305 @default.
- W3164349968 cites W2050621940 @default.
- W3164349968 cites W2054518038 @default.
- W3164349968 cites W2055987794 @default.
- W3164349968 cites W2057456873 @default.
- W3164349968 cites W2058411257 @default.
- W3164349968 cites W2060996905 @default.
- W3164349968 cites W2067911388 @default.
- W3164349968 cites W2099039770 @default.
- W3164349968 cites W2101621979 @default.
- W3164349968 cites W2102636611 @default.
- W3164349968 cites W2106064134 @default.
- W3164349968 cites W2110335151 @default.
- W3164349968 cites W2116111392 @default.
- W3164349968 cites W2116204383 @default.
- W3164349968 cites W2117478434 @default.
- W3164349968 cites W2119632499 @default.
- W3164349968 cites W2120238938 @default.
- W3164349968 cites W2123600031 @default.
- W3164349968 cites W2123690291 @default.
- W3164349968 cites W2127435093 @default.
- W3164349968 cites W2128915255 @default.
- W3164349968 cites W2130410032 @default.
- W3164349968 cites W2135445066 @default.
- W3164349968 cites W2148294117 @default.
- W3164349968 cites W2150023121 @default.
- W3164349968 cites W2154770881 @default.
- W3164349968 cites W2157398085 @default.
- W3164349968 cites W2162281650 @default.
- W3164349968 cites W2164207497 @default.
- W3164349968 cites W2169773990 @default.
- W3164349968 cites W2171607086 @default.
- W3164349968 cites W2181000836 @default.
- W3164349968 cites W2187273062 @default.
- W3164349968 cites W2263977295 @default.
- W3164349968 cites W2292406565 @default.
- W3164349968 cites W2517379430 @default.
- W3164349968 cites W2534066018 @default.
- W3164349968 cites W2537059504 @default.
- W3164349968 cites W2586824663 @default.
- W3164349968 cites W2598633385 @default.
- W3164349968 cites W2605621130 @default.
- W3164349968 cites W2789418861 @default.
- W3164349968 cites W2791353709 @default.
- W3164349968 cites W2792314520 @default.
- W3164349968 cites W2793674395 @default.
- W3164349968 cites W2794843283 @default.
- W3164349968 cites W2810416640 @default.
- W3164349968 cites W2886631752 @default.
- W3164349968 cites W2887710876 @default.
- W3164349968 cites W2888922956 @default.
- W3164349968 cites W2890361416 @default.
- W3164349968 cites W2900044275 @default.
- W3164349968 cites W2900327507 @default.
- W3164349968 cites W2908303872 @default.
- W3164349968 cites W2914523491 @default.
- W3164349968 cites W2924802385 @default.
- W3164349968 cites W2929067327 @default.
- W3164349968 cites W2937851806 @default.
- W3164349968 cites W2949875906 @default.
- W3164349968 cites W2951796795 @default.
- W3164349968 cites W2952033584 @default.
- W3164349968 cites W2969254469 @default.
- W3164349968 cites W2981549736 @default.
- W3164349968 cites W2997628301 @default.
- W3164349968 cites W3000111529 @default.