Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164371311> ?p ?o ?g. }
- W3164371311 endingPage "495" @default.
- W3164371311 startingPage "479" @default.
- W3164371311 abstract "Current understanding of amyloid-β protein (Aβ) aggregation and toxicity provides an extensive list of drugs for treating Alzheimer's disease (AD); however, one of the most promising strategies for its treatment has been tri-peptides.The aim of this study is to examine those tri-peptides, such as Arg-Arg-Try (RRY), which have the potential of Aβ1-42 aggregating inhibition and Aβ clearance.In the present study, in silico, in vitro, and in vivo studies were integrated for screening tri-peptides binding to Aβ, then evaluating its inhibition of aggregation of Aβ, and finally its rescuing cognitive deficit.In the in silico simulations, molecular docking and molecular dynamics determined that seven top-ranking tri-peptides could bind to Aβ1-42 and form stable complexes. Circular dichroism, ThT assay, and transmission electron microscope indicated the seven tri-peptides might inhibit the aggregation of Aβ1-42in vitro. In the in vivo studies, Morris water maze, ELISA, and Diolistic staining were used, and data showed that RRY was capable of rescuing the Aβ1-42-induced cognitive deficit, reducing the Aβ1-42 load and increasing the dendritic spines in the transgenic mouse model.Such converging outcomes from three consecutive studies lead us to conclude that RRY is a preferred inhibitor of Aβ1-42 aggregation and treatment for Aβ-induced cognitive deficit." @default.
- W3164371311 created "2021-06-07" @default.
- W3164371311 creator A5004855793 @default.
- W3164371311 creator A5012997422 @default.
- W3164371311 creator A5020595100 @default.
- W3164371311 creator A5022725431 @default.
- W3164371311 creator A5027695680 @default.
- W3164371311 creator A5031612412 @default.
- W3164371311 creator A5031973253 @default.
- W3164371311 creator A5039009774 @default.
- W3164371311 creator A5060110137 @default.
- W3164371311 creator A5063514061 @default.
- W3164371311 creator A5067963962 @default.
- W3164371311 creator A5070520625 @default.
- W3164371311 creator A5075618375 @default.
- W3164371311 date "2021-06-08" @default.
- W3164371311 modified "2023-10-16" @default.
- W3164371311 title "RRY Inhibits Amyloid-β1–42 Peptide Aggregation and Neurotoxicity" @default.
- W3164371311 cites W1493833772 @default.
- W3164371311 cites W1602771322 @default.
- W3164371311 cites W1617965928 @default.
- W3164371311 cites W1967523479 @default.
- W3164371311 cites W1967838681 @default.
- W3164371311 cites W1967917932 @default.
- W3164371311 cites W1973479349 @default.
- W3164371311 cites W1976161355 @default.
- W3164371311 cites W1976499671 @default.
- W3164371311 cites W1978314140 @default.
- W3164371311 cites W1978330227 @default.
- W3164371311 cites W1980750700 @default.
- W3164371311 cites W1982046519 @default.
- W3164371311 cites W1982244038 @default.
- W3164371311 cites W1983270545 @default.
- W3164371311 cites W1983728938 @default.
- W3164371311 cites W1994580609 @default.
- W3164371311 cites W1995524817 @default.
- W3164371311 cites W2001370623 @default.
- W3164371311 cites W2002181764 @default.
- W3164371311 cites W2003223057 @default.
- W3164371311 cites W2016447529 @default.
- W3164371311 cites W2018650092 @default.
- W3164371311 cites W2022532556 @default.
- W3164371311 cites W2024473468 @default.
- W3164371311 cites W2025070688 @default.
- W3164371311 cites W2029073267 @default.
- W3164371311 cites W2037617444 @default.
- W3164371311 cites W2041464039 @default.
- W3164371311 cites W2043332654 @default.
- W3164371311 cites W2046059051 @default.
- W3164371311 cites W2047190839 @default.
- W3164371311 cites W2052135835 @default.
- W3164371311 cites W2059795294 @default.
- W3164371311 cites W2060240527 @default.
- W3164371311 cites W2063699848 @default.
- W3164371311 cites W2066892610 @default.
- W3164371311 cites W2067174909 @default.
- W3164371311 cites W2069123478 @default.
- W3164371311 cites W2079219702 @default.
- W3164371311 cites W2079749054 @default.
- W3164371311 cites W2082429191 @default.
- W3164371311 cites W2089501103 @default.
- W3164371311 cites W2096410114 @default.
- W3164371311 cites W2106140689 @default.
- W3164371311 cites W2108150032 @default.
- W3164371311 cites W2108398194 @default.
- W3164371311 cites W2108475007 @default.
- W3164371311 cites W2109727228 @default.
- W3164371311 cites W2112645135 @default.
- W3164371311 cites W2112878090 @default.
- W3164371311 cites W2118233996 @default.
- W3164371311 cites W2121753059 @default.
- W3164371311 cites W2122294662 @default.
- W3164371311 cites W2122814674 @default.
- W3164371311 cites W2126402425 @default.
- W3164371311 cites W2128120672 @default.
- W3164371311 cites W2132562756 @default.
- W3164371311 cites W2134802476 @default.
- W3164371311 cites W2134967712 @default.
- W3164371311 cites W2147231139 @default.
- W3164371311 cites W2147993766 @default.
- W3164371311 cites W2148714108 @default.
- W3164371311 cites W2151409678 @default.
- W3164371311 cites W2171268876 @default.
- W3164371311 cites W2171898817 @default.
- W3164371311 doi "https://doi.org/10.3233/adr-210012" @default.
- W3164371311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8293670" @default.
- W3164371311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34368633" @default.
- W3164371311 hasPublicationYear "2021" @default.
- W3164371311 type Work @default.
- W3164371311 sameAs 3164371311 @default.
- W3164371311 citedByCount "2" @default.
- W3164371311 countsByYear W31643713112023 @default.
- W3164371311 crossrefType "journal-article" @default.
- W3164371311 hasAuthorship W3164371311A5004855793 @default.
- W3164371311 hasAuthorship W3164371311A5012997422 @default.
- W3164371311 hasAuthorship W3164371311A5020595100 @default.
- W3164371311 hasAuthorship W3164371311A5022725431 @default.
- W3164371311 hasAuthorship W3164371311A5027695680 @default.