Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164385462> ?p ?o ?g. }
- W3164385462 endingPage "460" @default.
- W3164385462 startingPage "460" @default.
- W3164385462 abstract "We studied the overview of drug discovery and development to understand the recent trends and potential success factors of interorganizational collaboration by reviewing 1204 transactions performed until 2019 for 107 anticancer drugs approved by the US Food and Drug Administration (FDA) from 1999 to 2018. Immune checkpoint blockade was found to be a significantly active area in interorganizational transactions, especially the number of alliances, compared with other mechanisms of action of small molecules and biologics for cancer treatment. Furthermore, the analysis of pembrolizumab and nivolumab showed that the number of approved indications for these two drugs has been rapidly expanding since their first approval in 2014. Examination of the acquisitions and alliances regarding pembrolizumab and nivolumab showed that many combination partners were developed by US-based biotechnology or start-up companies, the majority of which were biologics. These findings suggest that immune checkpoint blockade is a paradigm for cancer treatment, resulting in huge product sales and continuous indication expansion. Additionally, interorganizational collaboration, especially trial collaboration, is a strategic approach for the development of immune checkpoint blockade agents. The translation of these empirical practices to new drug candidates is expected for the research and development of innovative drugs in the future." @default.
- W3164385462 created "2021-06-07" @default.
- W3164385462 creator A5002445361 @default.
- W3164385462 creator A5009577771 @default.
- W3164385462 creator A5040309932 @default.
- W3164385462 creator A5045966318 @default.
- W3164385462 creator A5049599111 @default.
- W3164385462 date "2021-05-24" @default.
- W3164385462 modified "2023-09-26" @default.
- W3164385462 title "Dynamic Collaborations for the Development of Immune Checkpoint Blockade Agents" @default.
- W3164385462 cites W1534849470 @default.
- W3164385462 cites W1538902372 @default.
- W3164385462 cites W1568317937 @default.
- W3164385462 cites W1895993106 @default.
- W3164385462 cites W1913780655 @default.
- W3164385462 cites W1969393470 @default.
- W3164385462 cites W1976145004 @default.
- W3164385462 cites W1994750296 @default.
- W3164385462 cites W2008573694 @default.
- W3164385462 cites W2009720434 @default.
- W3164385462 cites W2016732129 @default.
- W3164385462 cites W2020434234 @default.
- W3164385462 cites W2028376975 @default.
- W3164385462 cites W2050477250 @default.
- W3164385462 cites W2056535502 @default.
- W3164385462 cites W2058743530 @default.
- W3164385462 cites W2060070314 @default.
- W3164385462 cites W2061061337 @default.
- W3164385462 cites W2062789265 @default.
- W3164385462 cites W2066671159 @default.
- W3164385462 cites W2069012311 @default.
- W3164385462 cites W2075819066 @default.
- W3164385462 cites W2087186136 @default.
- W3164385462 cites W2096322385 @default.
- W3164385462 cites W2101990345 @default.
- W3164385462 cites W2107752337 @default.
- W3164385462 cites W2109485845 @default.
- W3164385462 cites W2118471749 @default.
- W3164385462 cites W2121175754 @default.
- W3164385462 cites W2121556079 @default.
- W3164385462 cites W2132724845 @default.
- W3164385462 cites W2136859769 @default.
- W3164385462 cites W2143772132 @default.
- W3164385462 cites W2145857936 @default.
- W3164385462 cites W2147328441 @default.
- W3164385462 cites W2166209362 @default.
- W3164385462 cites W2187430385 @default.
- W3164385462 cites W2296047035 @default.
- W3164385462 cites W2747016053 @default.
- W3164385462 cites W2789937708 @default.
- W3164385462 cites W2794577178 @default.
- W3164385462 cites W2796643083 @default.
- W3164385462 cites W2896996832 @default.
- W3164385462 cites W2902968854 @default.
- W3164385462 cites W3002914689 @default.
- W3164385462 cites W3041622498 @default.
- W3164385462 cites W3097921797 @default.
- W3164385462 doi "https://doi.org/10.3390/jpm11060460" @default.
- W3164385462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8225058" @default.
- W3164385462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34073680" @default.
- W3164385462 hasPublicationYear "2021" @default.
- W3164385462 type Work @default.
- W3164385462 sameAs 3164385462 @default.
- W3164385462 citedByCount "4" @default.
- W3164385462 countsByYear W31643854622022 @default.
- W3164385462 countsByYear W31643854622023 @default.
- W3164385462 crossrefType "journal-article" @default.
- W3164385462 hasAuthorship W3164385462A5002445361 @default.
- W3164385462 hasAuthorship W3164385462A5009577771 @default.
- W3164385462 hasAuthorship W3164385462A5040309932 @default.
- W3164385462 hasAuthorship W3164385462A5045966318 @default.
- W3164385462 hasAuthorship W3164385462A5049599111 @default.
- W3164385462 hasBestOaLocation W31643854621 @default.
- W3164385462 hasConcept C126322002 @default.
- W3164385462 hasConcept C144133560 @default.
- W3164385462 hasConcept C170493617 @default.
- W3164385462 hasConcept C203014093 @default.
- W3164385462 hasConcept C2777701055 @default.
- W3164385462 hasConcept C2778468042 @default.
- W3164385462 hasConcept C2780030458 @default.
- W3164385462 hasConcept C2780035454 @default.
- W3164385462 hasConcept C2780057760 @default.
- W3164385462 hasConcept C2780851360 @default.
- W3164385462 hasConcept C64903051 @default.
- W3164385462 hasConcept C71924100 @default.
- W3164385462 hasConcept C8891405 @default.
- W3164385462 hasConcept C98274493 @default.
- W3164385462 hasConceptScore W3164385462C126322002 @default.
- W3164385462 hasConceptScore W3164385462C144133560 @default.
- W3164385462 hasConceptScore W3164385462C170493617 @default.
- W3164385462 hasConceptScore W3164385462C203014093 @default.
- W3164385462 hasConceptScore W3164385462C2777701055 @default.
- W3164385462 hasConceptScore W3164385462C2778468042 @default.
- W3164385462 hasConceptScore W3164385462C2780030458 @default.
- W3164385462 hasConceptScore W3164385462C2780035454 @default.
- W3164385462 hasConceptScore W3164385462C2780057760 @default.
- W3164385462 hasConceptScore W3164385462C2780851360 @default.
- W3164385462 hasConceptScore W3164385462C64903051 @default.