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- W3164423621 abstract "Billions of years of Darwinian evolution has led to the emergence of highly sophisticated and diverse life forms on Earth. Inspired by natural evolution, similar principles have been adopted in laboratory evolution for the fast optimization of genes and proteins for specific applications. In this review, we highlight state-of-the-art laboratory evolution strategies for protein engineering, with a special emphasis on in vitro strategies. We further describe how recent progress in microfluidic technology has allowed the generation and manipulation of artificial compartments for high-throughput laboratory evolution experiments. Expectations for the future are high: we foresee a revolution on-a-chip." @default.
- W3164423621 created "2021-06-07" @default.
- W3164423621 creator A5010586842 @default.
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- W3164423621 creator A5068215729 @default.
- W3164423621 creator A5070006603 @default.
- W3164423621 creator A5073457405 @default.
- W3164423621 date "2022-01-01" @default.
- W3164423621 modified "2023-09-25" @default.
- W3164423621 title "(R)evolution-on-a-chip" @default.
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- W3164423621 doi "https://doi.org/10.1016/j.tibtech.2021.04.009" @default.
- W3164423621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34049723" @default.
- W3164423621 hasPublicationYear "2022" @default.