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• W3164457652 abstract "Transformation of astrocytes into reactive states is considered one of the major pathological hallmarks of prion and other neurodegenerative diseases. Recent years witnessed a growing appreciation of the view that reactive astrocytes are intimately involved in chronic neurodegeneration; however, little is known about their role in disease pathogenesis. The current article reviews the progress of the last few years and critically discusses controversial questions of whether reactive astrocytes associated with prion diseases are neurotoxic or neuroprotective and whether bidirectional A1–A2 model is applicable for describing polarization of astrocytes. Moreover, other important topics, including reversibility of a transition to a reactive state, along with the role of microglia and other stimuli in triggering astrocyte activation are reviewed. Defining the role of reactive astrocytes in pathogenesis of neurodegenerative diseases will open unrealized opportunities for developing new therapeutic approaches against prion and other neurodegenerative diseases." @default.
• W3164457652 created "2021-06-07" @default.
• W3164457652 creator A5032924150 @default.
• W3164457652 date "2021-01-01" @default.
• W3164457652 modified "2023-10-16" @default.
• W3164457652 title "On the reactive states of astrocytes in prion diseases" @default.
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• W3164457652 doi "https://doi.org/10.1080/19336896.2021.1930852" @default.
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