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- W3164474219 abstract "To investigate whether use of chlorhexidine gluconate 4% or povidone-iodine 10% vaginal and perineal antiseptic preparation significantly affects the rate of surgical site infection after laparoscopic hysterectomy. This was a retrospective cohort study of adult patients from the Carolina Data Warehouse for Health (a central database with clinical, research, and administrative data) undergoing laparoscopic hysterectomy for benign or malignant indications between 2016 and 2018. Type of vaginal antiseptic was reported as either 4% chlorhexidine gluconate or 10% povidone-iodine solution. Our primary outcome was 30-day surgical site infection (superficial/incisional and deep/organ space infections). Demographic and clinical characteristics were compared among vaginal antiseptic cohorts. Logistic regression was performed adjusting for patient demographic and perioperative variables to identify a potential association between type of vaginal antiseptic solution and surgical site infection. A total of 410 patients were identified for inclusion, with 336 (82%) receiving povidone-iodine vaginal antisepsis and 75 (18%) receiving chlorhexidine gluconate antisepsis. The rate of surgical site infection was similar in the povidone-iodine and the chlorhexidine group (5% vs 8%, P = 0.26). The rates of superficial (3% vs 5%, P = 0.27) and deep (2% vs 3%, P > 0.99) surgical site infection also remained similar between groups. After adjustment for patient and perioperative characteristics, there was no statistically significant difference in the risk of surgical site infection for patients who received povidone-iodine compared to chlorhexidine gluconate vaginal antisepsis (aOR = 0.74, 95% CI = 0.27 to 2.08). There remained an overall low incidence of surgical site infection after laparoscopic hysterectomy. For women undergoing laparoscopic hysterectomy, use of either povidone-iodine or chlorhexidine gluconate vaginal antisepsis did not significantly influence the risk of 30-day surgical site infection. Patient tolerance, surgeon preference, and cost-effectiveness can continue to guide the choice of vaginal antiseptic agent at the time of laparoscopic hysterectomy as we await further prospective data." @default.
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- W3164474219 date "2021-06-01" @default.
- W3164474219 modified "2023-09-26" @default.
- W3164474219 title "38 An investigation of chlorhexidine gluconate versus povidone-iodine vaginal antisepsis and rate of surgical site infection in laparoscopic hysterectomy" @default.
- W3164474219 doi "https://doi.org/10.1016/j.ajog.2021.04.063" @default.
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