Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164496834> ?p ?o ?g. }
- W3164496834 abstract "Molecular mechanisms and targets of cyclic guanosine monophosphate (cGMP) accounting for vascular smooth muscles (VSM) contractility are reviewed. Mathematical models of five published mechanisms are presented, and four novel mechanisms are proposed. cGMP, which is primarily produced by the nitric oxide (NO) dependent soluble guanylate cyclase (sGC), activates cGMP-dependent protein kinase (PKG). The NO/cGMP/PKG signaling pathway targets are the mechanisms that regulate cytosolic calcium ([Ca2+]i) signaling and those implicated in the Ca2+-desensitization of the contractile apparatus. In addition to previous mathematical models of cGMP-mediated molecular mechanisms targeting [Ca2+]i regulation, such as large-conductance Ca2+-activated K+ channels (BKCa), Ca2+-dependent Cl− channels (ClCa), Na+/Ca2+ exchanger (NCX), Na+/K+/Cl− cotransport (NKCC), and Na+/K+-ATPase (NKA), other four novel mechanisms are proposed here based on the existing but perhaps overlooked experimental results. These are the effects of cGMP on the sarco−/endo- plasmic reticulum Ca2+-ATPase (SERCA), the plasma membrane Ca2+-ATPase (PMCA), the inositol 1,4,5-trisphosphate (IP3) receptor channels type 1 (IP3R1), and on the myosin light chain phosphatase (MLCP), which is implicated in the Ca2+-desensitization. Different modeling approaches are presented and discussed, and novel model descriptions are proposed." @default.
- W3164496834 created "2021-06-07" @default.
- W3164496834 creator A5064887279 @default.
- W3164496834 date "2021-07-07" @default.
- W3164496834 modified "2023-09-26" @default.
- W3164496834 title "Molecular Mechanisms and Targets of Cyclic Guanosine Monophosphate (cGMP) in Vascular Smooth Muscles" @default.
- W3164496834 cites W120532893 @default.
- W3164496834 cites W1509564023 @default.
- W3164496834 cites W1526187099 @default.
- W3164496834 cites W1567418767 @default.
- W3164496834 cites W1584737584 @default.
- W3164496834 cites W1600173404 @default.
- W3164496834 cites W1834747511 @default.
- W3164496834 cites W1863186034 @default.
- W3164496834 cites W1894088205 @default.
- W3164496834 cites W1921519961 @default.
- W3164496834 cites W1938377867 @default.
- W3164496834 cites W1958244357 @default.
- W3164496834 cites W1961081692 @default.
- W3164496834 cites W1964186367 @default.
- W3164496834 cites W1972331465 @default.
- W3164496834 cites W1984306408 @default.
- W3164496834 cites W1986338378 @default.
- W3164496834 cites W1987784438 @default.
- W3164496834 cites W1993185375 @default.
- W3164496834 cites W1994802893 @default.
- W3164496834 cites W1995978489 @default.
- W3164496834 cites W1997332134 @default.
- W3164496834 cites W2000156315 @default.
- W3164496834 cites W2000665249 @default.
- W3164496834 cites W2004643272 @default.
- W3164496834 cites W2005971493 @default.
- W3164496834 cites W2009899857 @default.
- W3164496834 cites W2015934609 @default.
- W3164496834 cites W2019822857 @default.
- W3164496834 cites W2020750779 @default.
- W3164496834 cites W2023033897 @default.
- W3164496834 cites W2025644841 @default.
- W3164496834 cites W2028754469 @default.
- W3164496834 cites W2032295238 @default.
- W3164496834 cites W2035348154 @default.
- W3164496834 cites W2036874203 @default.
- W3164496834 cites W2038938013 @default.
- W3164496834 cites W2048117991 @default.
- W3164496834 cites W2051230900 @default.
- W3164496834 cites W2052666798 @default.
- W3164496834 cites W2053807796 @default.
- W3164496834 cites W2057185402 @default.
- W3164496834 cites W2058106736 @default.
- W3164496834 cites W2065928074 @default.
- W3164496834 cites W2067598924 @default.
- W3164496834 cites W2068847639 @default.
- W3164496834 cites W2069597305 @default.
- W3164496834 cites W2073508107 @default.
- W3164496834 cites W2074476430 @default.
- W3164496834 cites W2076997567 @default.
- W3164496834 cites W2080814134 @default.
- W3164496834 cites W2082988280 @default.
- W3164496834 cites W2091526004 @default.
- W3164496834 cites W2092019165 @default.
- W3164496834 cites W2096271770 @default.
- W3164496834 cites W2097098660 @default.
- W3164496834 cites W2101998405 @default.
- W3164496834 cites W2109679295 @default.
- W3164496834 cites W2109835398 @default.
- W3164496834 cites W2111900761 @default.
- W3164496834 cites W2120556384 @default.
- W3164496834 cites W2121452261 @default.
- W3164496834 cites W2123649025 @default.
- W3164496834 cites W2125590987 @default.
- W3164496834 cites W2126046035 @default.
- W3164496834 cites W2130258723 @default.
- W3164496834 cites W2130818764 @default.
- W3164496834 cites W2131684714 @default.
- W3164496834 cites W2138742704 @default.
- W3164496834 cites W2141203688 @default.
- W3164496834 cites W2144371871 @default.
- W3164496834 cites W2146058743 @default.
- W3164496834 cites W2147534811 @default.
- W3164496834 cites W2156307604 @default.
- W3164496834 cites W2160944315 @default.
- W3164496834 cites W2161827251 @default.
- W3164496834 cites W2170151360 @default.
- W3164496834 cites W2170899424 @default.
- W3164496834 cites W2240768837 @default.
- W3164496834 cites W2297887849 @default.
- W3164496834 cites W2325318720 @default.
- W3164496834 cites W2326671771 @default.
- W3164496834 cites W2346176709 @default.
- W3164496834 cites W261751860 @default.
- W3164496834 cites W2766498431 @default.
- W3164496834 cites W2802181904 @default.
- W3164496834 cites W2887473550 @default.
- W3164496834 cites W2971368798 @default.
- W3164496834 cites W3005672853 @default.
- W3164496834 cites W307883368 @default.
- W3164496834 cites W4255205881 @default.
- W3164496834 doi "https://doi.org/10.5772/intechopen.97708" @default.
- W3164496834 hasPublicationYear "2021" @default.
- W3164496834 type Work @default.