Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164515955> ?p ?o ?g. }
- W3164515955 endingPage "103392" @default.
- W3164515955 startingPage "103392" @default.
- W3164515955 abstract "Multiple sclerosis (MS) is after trauma the most important neurological disease in young adults, affecting 1 per 1000 individuals. With currently available medications, most of these targeting the immune system, satisfactory results have been obtained in patients with relapsing MS, but these can have serious adverse effects. Moreover, despite some promising developments, such as with B cell targeting therapies or sphingosine-1-phosphate modulating drugs, there still is a high unmet need of safe drugs with broad efficacy in patients with progressive MS. Despite substantial investments and intensive preclinical research, the proportion of promising lead compounds that reaches the approved drug status remains disappointingly low. One cause lies in the poor predictive validity of MS animal models used in the translation of pathogenic mechanisms into safe and effective treatments for the patient. This disturbing situation has raised criticism against the relevance of animal models used in preclinical research and calls for improvement of these models. This publication presents a potentially useful strategy to enhance the predictive validity of MS animal models, namely, to analyze the causes of failure in forward translation (lab to clinic) via reverse translation (clinic to lab). Through this strategy new insights can be gained that can help generate more valid MS models." @default.
- W3164515955 created "2021-06-07" @default.
- W3164515955 creator A5027685825 @default.
- W3164515955 creator A5036389128 @default.
- W3164515955 creator A5036457360 @default.
- W3164515955 creator A5053447140 @default.
- W3164515955 creator A5078507054 @default.
- W3164515955 date "2021-06-01" @default.
- W3164515955 modified "2023-10-18" @default.
- W3164515955 title "Multiple sclerosis and drug discovery: A work of translation" @default.
- W3164515955 cites W1145189572 @default.
- W3164515955 cites W1523338791 @default.
- W3164515955 cites W1560762441 @default.
- W3164515955 cites W1913155416 @default.
- W3164515955 cites W1944517551 @default.
- W3164515955 cites W1970547229 @default.
- W3164515955 cites W1972752407 @default.
- W3164515955 cites W1986913568 @default.
- W3164515955 cites W1987625972 @default.
- W3164515955 cites W1995234326 @default.
- W3164515955 cites W2004118951 @default.
- W3164515955 cites W2006197871 @default.
- W3164515955 cites W2009495078 @default.
- W3164515955 cites W2013917285 @default.
- W3164515955 cites W2017006890 @default.
- W3164515955 cites W2017332009 @default.
- W3164515955 cites W2024140382 @default.
- W3164515955 cites W2024568936 @default.
- W3164515955 cites W2024898420 @default.
- W3164515955 cites W2032875252 @default.
- W3164515955 cites W2037907937 @default.
- W3164515955 cites W2041482977 @default.
- W3164515955 cites W2042735882 @default.
- W3164515955 cites W2062601795 @default.
- W3164515955 cites W2069359761 @default.
- W3164515955 cites W2074924096 @default.
- W3164515955 cites W2086080135 @default.
- W3164515955 cites W2087909308 @default.
- W3164515955 cites W2096175009 @default.
- W3164515955 cites W2102938498 @default.
- W3164515955 cites W2102960796 @default.
- W3164515955 cites W2103849595 @default.
- W3164515955 cites W2104188690 @default.
- W3164515955 cites W2106968078 @default.
- W3164515955 cites W2109963121 @default.
- W3164515955 cites W2110843068 @default.
- W3164515955 cites W2114224507 @default.
- W3164515955 cites W2121968767 @default.
- W3164515955 cites W2125468126 @default.
- W3164515955 cites W2141111992 @default.
- W3164515955 cites W2151492920 @default.
- W3164515955 cites W2154337381 @default.
- W3164515955 cites W2162162619 @default.
- W3164515955 cites W2167846216 @default.
- W3164515955 cites W2167896409 @default.
- W3164515955 cites W2171953655 @default.
- W3164515955 cites W2261157573 @default.
- W3164515955 cites W2300922079 @default.
- W3164515955 cites W2337334490 @default.
- W3164515955 cites W2548933161 @default.
- W3164515955 cites W2549731291 @default.
- W3164515955 cites W2553562241 @default.
- W3164515955 cites W2558102406 @default.
- W3164515955 cites W2565433170 @default.
- W3164515955 cites W2565990505 @default.
- W3164515955 cites W2567490015 @default.
- W3164515955 cites W2741780122 @default.
- W3164515955 cites W2749786720 @default.
- W3164515955 cites W2750838281 @default.
- W3164515955 cites W2756391458 @default.
- W3164515955 cites W2900501647 @default.
- W3164515955 cites W2910037458 @default.
- W3164515955 cites W2910867209 @default.
- W3164515955 cites W2925207909 @default.
- W3164515955 cites W2944466104 @default.
- W3164515955 cites W2994779767 @default.
- W3164515955 cites W3088633119 @default.
- W3164515955 cites W3099145935 @default.
- W3164515955 cites W3120090657 @default.
- W3164515955 cites W3126493753 @default.
- W3164515955 cites W3132688803 @default.
- W3164515955 cites W3133100812 @default.
- W3164515955 cites W3173784878 @default.
- W3164515955 cites W4211254511 @default.
- W3164515955 doi "https://doi.org/10.1016/j.ebiom.2021.103392" @default.
- W3164515955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8245896" @default.
- W3164515955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34044219" @default.
- W3164515955 hasPublicationYear "2021" @default.
- W3164515955 type Work @default.
- W3164515955 sameAs 3164515955 @default.
- W3164515955 citedByCount "6" @default.
- W3164515955 countsByYear W31645159552022 @default.
- W3164515955 countsByYear W31645159552023 @default.
- W3164515955 crossrefType "journal-article" @default.
- W3164515955 hasAuthorship W3164515955A5027685825 @default.
- W3164515955 hasAuthorship W3164515955A5036389128 @default.
- W3164515955 hasAuthorship W3164515955A5036457360 @default.
- W3164515955 hasAuthorship W3164515955A5053447140 @default.