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- W3164524213 abstract "Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a key to immune suppressive microenvironment in solid tumors. Many studies have revealed the biology of Tregs in various human pathologies. Here we review recent understandings of the immunophenotypes and suppressive functions of Tregs in melanoma, including Treg recruitment and expansion in a tumor. Tregs are frequently accumulated in melanoma and the ratio of CD8+ T cells versus Tregs in the melanoma is predictive for patient survival. Hence, depletion of Tregs is a promising strategy for the enhancement of anti-melanoma immunity. Many recent studies are aimed to target Tregs in melanoma. Distinguishing Tregs from other immune cells and understanding the function of different subsets of Tregs may contribute to better therapeutic efficacy. Depletion of functional Tregs from the tumor microenvironment has been tested to induce clinically relevant immune responses against melanomas. However, the lack of Treg specific therapeutic antibodies or Treg specific depleting strategies is a big hurdle that is yet to be overcome. Additional studies to fine-tune currently available therapies and more agents that specifically and selectively target tumor infiltrating Tregs in melanoma are urgently needed." @default.
- W3164524213 created "2021-06-07" @default.
- W3164524213 creator A5004014762 @default.
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- W3164524213 creator A5051741885 @default.
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- W3164524213 creator A5079547381 @default.
- W3164524213 date "2021-04-19" @default.
- W3164524213 modified "2023-10-17" @default.
- W3164524213 title "Targeting regulatory T cells for immunotherapy in melanoma" @default.
- W3164524213 cites W128718553 @default.
- W3164524213 cites W1468140428 @default.
- W3164524213 cites W1499854106 @default.
- W3164524213 cites W1517049862 @default.
- W3164524213 cites W1517717066 @default.
- W3164524213 cites W1536980415 @default.
- W3164524213 cites W1543659825 @default.
- W3164524213 cites W1544895611 @default.
- W3164524213 cites W1552885427 @default.
- W3164524213 cites W1556237598 @default.
- W3164524213 cites W1567420244 @default.
- W3164524213 cites W1618337835 @default.
- W3164524213 cites W1941651450 @default.
- W3164524213 cites W1962920088 @default.
- W3164524213 cites W1963626506 @default.
- W3164524213 cites W1964389846 @default.
- W3164524213 cites W1967782952 @default.
- W3164524213 cites W1968059098 @default.
- W3164524213 cites W1975566288 @default.
- W3164524213 cites W1975677688 @default.
- W3164524213 cites W1977064347 @default.
- W3164524213 cites W1978410307 @default.
- W3164524213 cites W1983626382 @default.
- W3164524213 cites W1984543828 @default.
- W3164524213 cites W1987165863 @default.
- W3164524213 cites W1987802826 @default.
- W3164524213 cites W1988474688 @default.
- W3164524213 cites W1992249154 @default.
- W3164524213 cites W1993494729 @default.
- W3164524213 cites W1993764727 @default.
- W3164524213 cites W1993918137 @default.
- W3164524213 cites W1994160001 @default.
- W3164524213 cites W2000897207 @default.
- W3164524213 cites W2002726823 @default.
- W3164524213 cites W2005616249 @default.
- W3164524213 cites W2007631222 @default.
- W3164524213 cites W2011873300 @default.
- W3164524213 cites W2014634158 @default.
- W3164524213 cites W2014894665 @default.
- W3164524213 cites W2016910978 @default.
- W3164524213 cites W2018233112 @default.
- W3164524213 cites W2018426264 @default.
- W3164524213 cites W2019888542 @default.
- W3164524213 cites W2021866608 @default.
- W3164524213 cites W2022063033 @default.
- W3164524213 cites W2022208959 @default.
- W3164524213 cites W2022585261 @default.
- W3164524213 cites W2022614912 @default.
- W3164524213 cites W2023214087 @default.
- W3164524213 cites W2026383745 @default.
- W3164524213 cites W2026426963 @default.
- W3164524213 cites W2030689322 @default.
- W3164524213 cites W2033181170 @default.
- W3164524213 cites W2034607874 @default.
- W3164524213 cites W2041762667 @default.
- W3164524213 cites W2046972425 @default.
- W3164524213 cites W2051320960 @default.
- W3164524213 cites W2052073154 @default.
- W3164524213 cites W2054738595 @default.
- W3164524213 cites W2058250248 @default.
- W3164524213 cites W2059146779 @default.
- W3164524213 cites W2061071534 @default.
- W3164524213 cites W2063452120 @default.
- W3164524213 cites W2068639447 @default.
- W3164524213 cites W2068857175 @default.
- W3164524213 cites W2076956606 @default.
- W3164524213 cites W2077627244 @default.
- W3164524213 cites W2077702286 @default.
- W3164524213 cites W2077915163 @default.
- W3164524213 cites W2088414731 @default.
- W3164524213 cites W2091687780 @default.
- W3164524213 cites W2100553040 @default.
- W3164524213 cites W2101449057 @default.
- W3164524213 cites W2101581360 @default.
- W3164524213 cites W2104464991 @default.
- W3164524213 cites W2108722982 @default.
- W3164524213 cites W2108933323 @default.
- W3164524213 cites W2109077280 @default.
- W3164524213 cites W2111417631 @default.
- W3164524213 cites W2112123471 @default.
- W3164524213 cites W2113030185 @default.
- W3164524213 cites W2120233660 @default.
- W3164524213 cites W2121391430 @default.
- W3164524213 cites W2121626779 @default.
- W3164524213 cites W2123845047 @default.
- W3164524213 cites W2126028507 @default.
- W3164524213 cites W2128035403 @default.
- W3164524213 cites W2128864185 @default.