FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164545902> ?p ?o ?g. }

• W3164545902 endingPage "8498" @default.
• W3164545902 startingPage "8488" @default.
• W3164545902 abstract "The critical role of site-specific phosphorylation in eukaryotic transcription has motivated efforts to decipher the complex phosphorylation patterns exhibited by the carboxyl-terminal domain (CTD) of RNA polymerase II. Phosphorylation remains a challenging post-translational modification to characterize by mass spectrometry owing to the labile phosphate ester linkage and low stoichiometric prevalence, two features that complicate analysis by high-throughput MS/MS methods. Identifying phosphorylation sites represents one significant hurdle in decrypting the CTD phosphorylation, a problem exaggerated by a large number of potential phosphorylation sites. An even greater obstacle is decoding the dynamic phosphorylation pattern along the length of the periodic CTD sequence. Ultraviolet photodissociation (UVPD) is a high-energy ion activation method that provides ample backbone cleavages of peptides while preserving labile post-translational modifications that facilitate their confident localization. Herein, we report a quantitative parallel reaction monitoring (PRM) method developed to monitor spatiotemporal changes in site-specific Ser5 phosphorylation of the CTD by cyclin-dependent kinase 7 (CDK7) using UVPD for sequence identification, phosphosite localization, and differentiation of phosphopeptide isomers. We capitalize on the series of phospho-retaining fragment ions produced by UVPD to create unique transition lists that are pivotal for distinguishing the array of phosphopeptides generated from the CTD." @default.
• W3164545902 created "2021-06-07" @default.
• W3164545902 creator A5024404577 @default.
• W3164545902 creator A5025572710 @default.
• W3164545902 creator A5037799326 @default.
• W3164545902 creator A5052628663 @default.
• W3164545902 date "2021-05-31" @default.
• W3164545902 modified "2023-10-14" @default.
• W3164545902 title "Evaluating Spatiotemporal Dynamics of Phosphorylation of RNA Polymerase II Carboxy-Terminal Domain by Ultraviolet Photodissociation Mass Spectrometry" @default.
• W3164545902 cites W1856317036 @default.
• W3164545902 cites W1964259728 @default.
• W3164545902 cites W1976286254 @default.
• W3164545902 cites W1981930838 @default.
• W3164545902 cites W2011061591 @default.
• W3164545902 cites W2032742580 @default.
• W3164545902 cites W2045232646 @default.
• W3164545902 cites W2045755743 @default.
• W3164545902 cites W2047929205 @default.
• W3164545902 cites W2057179319 @default.
• W3164545902 cites W2074304165 @default.
• W3164545902 cites W2092014341 @default.
• W3164545902 cites W2100649212 @default.
• W3164545902 cites W2102440675 @default.
• W3164545902 cites W2103931447 @default.
• W3164545902 cites W2107710616 @default.
• W3164545902 cites W2123603532 @default.
• W3164545902 cites W2128426510 @default.
• W3164545902 cites W2182554819 @default.
• W3164545902 cites W2233598149 @default.
• W3164545902 cites W2256726566 @default.
• W3164545902 cites W2261490373 @default.
• W3164545902 cites W2289585679 @default.
• W3164545902 cites W2315705994 @default.
• W3164545902 cites W2330597159 @default.
• W3164545902 cites W2338828725 @default.
• W3164545902 cites W2436016506 @default.
• W3164545902 cites W2496859259 @default.
• W3164545902 cites W2554756234 @default.
• W3164545902 cites W2604924179 @default.
• W3164545902 cites W2606647715 @default.
• W3164545902 cites W2606916790 @default.
• W3164545902 cites W2612733724 @default.
• W3164545902 cites W2730255373 @default.
• W3164545902 cites W2741454017 @default.
• W3164545902 cites W2802654440 @default.
• W3164545902 cites W2805413541 @default.
• W3164545902 cites W2890702814 @default.
• W3164545902 cites W2901651792 @default.
• W3164545902 cites W2945823364 @default.
• W3164545902 cites W2946658064 @default.
• W3164545902 cites W2963508943 @default.
• W3164545902 cites W2966394534 @default.
• W3164545902 cites W2977061458 @default.
• W3164545902 cites W2989956260 @default.
• W3164545902 cites W2992890944 @default.
• W3164545902 cites W2995723120 @default.
• W3164545902 cites W3033584837 @default.
• W3164545902 cites W3035952314 @default.
• W3164545902 cites W3039492798 @default.
• W3164545902 cites W3042135946 @default.
• W3164545902 cites W3134718897 @default.
• W3164545902 cites W3175059578 @default.
• W3164545902 cites W4211007003 @default.
• W3164545902 doi "https://doi.org/10.1021/jacs.1c03321" @default.
• W3164545902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8377744" @default.
• W3164545902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34053220" @default.
• W3164545902 hasPublicationYear "2021" @default.
• W3164545902 type Work @default.
• W3164545902 sameAs 3164545902 @default.
• W3164545902 citedByCount "4" @default.
• W3164545902 countsByYear W31645459022021 @default.
• W3164545902 countsByYear W31645459022022 @default.
• W3164545902 countsByYear W31645459022023 @default.
• W3164545902 crossrefType "journal-article" @default.
• W3164545902 hasAuthorship W3164545902A5024404577 @default.
• W3164545902 hasAuthorship W3164545902A5025572710 @default.
• W3164545902 hasAuthorship W3164545902A5037799326 @default.
• W3164545902 hasAuthorship W3164545902A5052628663 @default.
• W3164545902 hasBestOaLocation W31645459022 @default.
• W3164545902 hasConcept C101762097 @default.
• W3164545902 hasConcept C104317684 @default.
• W3164545902 hasConcept C111368507 @default.
• W3164545902 hasConcept C11960822 @default.
• W3164545902 hasConcept C125533998 @default.
• W3164545902 hasConcept C12554922 @default.
• W3164545902 hasConcept C127313418 @default.
• W3164545902 hasConcept C150194340 @default.
• W3164545902 hasConcept C162356407 @default.
• W3164545902 hasConcept C185592680 @default.
• W3164545902 hasConcept C2779933727 @default.
• W3164545902 hasConcept C43617362 @default.
• W3164545902 hasConcept C55493867 @default.
• W3164545902 hasConcept C64350747 @default.
• W3164545902 hasConcept C70721500 @default.
• W3164545902 hasConcept C86803240 @default.
• W3164545902 hasConcept C87325107 @default.
• W3164545902 hasConcept C97029542 @default.
• W3164545902 hasConceptScore W3164545902C101762097 @default.

• next