Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164560156> ?p ?o ?g. }
- W3164560156 endingPage "1455" @default.
- W3164560156 startingPage "1445" @default.
- W3164560156 abstract "Exposure to polycyclic aromatic hydrocarbons (PAHs) often occurs as complex chemical mixtures, which are linked to numerous adverse health outcomes in humans, with cancer as the greatest concern. The cancer risk associated with PAH exposures is commonly evaluated using the relative potency factor (RPF) approach, which estimates PAH mixture carcinogenic potential based on the sum of relative potency estimates of individual PAHs, compared to benzo[a]pyrene (BAP), a reference carcinogen. The present study evaluates molecular mechanisms related to PAH cancer risk through integration of transcriptomic and bioinformatic approaches in a 3D human bronchial epithelial cell model. Genes with significant differential expression from human bronchial epithelium exposed to PAHs were analyzed using a weighted gene coexpression network analysis (WGCNA) two-tiered approach: first to identify gene sets comodulated to RPF and second to link genes to a more comprehensive list of regulatory values, including inhalation-specific risk values. Over 3000 genes associated with processes of cell cycle regulation, inflammation, DNA damage, and cell adhesion processes were found to be comodulated with increasing RPF with pathways for cell cycle S phase and cytoskeleton actin identified as the most significantly enriched biological networks correlated to RPF. In addition, comodulated genes were linked to additional cancer-relevant risk values, including inhalation unit risks, oral cancer slope factors, and cancer hazard classifications from the World Health Organization's International Agency for Research on Cancer (IARC). These gene sets represent potential biomarkers that could be used to evaluate cancer risk associated with PAH mixtures. Among the values tested, RPF values and IARC categorizations shared the most similar responses in positively and negatively correlated gene modules. Together, we demonstrated a novel manner of integrating gene sets with chemical toxicity equivalence estimates through WGCNA to understand potential mechanisms." @default.
- W3164560156 created "2021-06-07" @default.
- W3164560156 creator A5074912970 @default.
- W3164560156 creator A5075469209 @default.
- W3164560156 creator A5077210745 @default.
- W3164560156 date "2021-05-28" @default.
- W3164560156 modified "2023-10-11" @default.
- W3164560156 title "Linking Coregulated Gene Modules with Polycyclic Aromatic Hydrocarbon-Related Cancer Risk in the 3D Human Bronchial Epithelium" @default.
- W3164560156 cites W1540016031 @default.
- W3164560156 cites W1624859412 @default.
- W3164560156 cites W1626705661 @default.
- W3164560156 cites W1908738074 @default.
- W3164560156 cites W1935129283 @default.
- W3164560156 cites W1966327575 @default.
- W3164560156 cites W1966806137 @default.
- W3164560156 cites W1967795278 @default.
- W3164560156 cites W1978679318 @default.
- W3164560156 cites W1979574159 @default.
- W3164560156 cites W1998008917 @default.
- W3164560156 cites W1998862010 @default.
- W3164560156 cites W2004305401 @default.
- W3164560156 cites W2005250753 @default.
- W3164560156 cites W2006690303 @default.
- W3164560156 cites W2021074697 @default.
- W3164560156 cites W2022089088 @default.
- W3164560156 cites W2029214473 @default.
- W3164560156 cites W2029891787 @default.
- W3164560156 cites W2029895352 @default.
- W3164560156 cites W2030890458 @default.
- W3164560156 cites W2040047879 @default.
- W3164560156 cites W2041473955 @default.
- W3164560156 cites W2046528317 @default.
- W3164560156 cites W2060394144 @default.
- W3164560156 cites W2060705109 @default.
- W3164560156 cites W2061834412 @default.
- W3164560156 cites W2076314388 @default.
- W3164560156 cites W2077810031 @default.
- W3164560156 cites W2080540038 @default.
- W3164560156 cites W2087732778 @default.
- W3164560156 cites W2097065948 @default.
- W3164560156 cites W2111789320 @default.
- W3164560156 cites W2117335756 @default.
- W3164560156 cites W2118421662 @default.
- W3164560156 cites W2141341794 @default.
- W3164560156 cites W2141458291 @default.
- W3164560156 cites W2144656637 @default.
- W3164560156 cites W2159334494 @default.
- W3164560156 cites W2159675211 @default.
- W3164560156 cites W2161604082 @default.
- W3164560156 cites W2166997364 @default.
- W3164560156 cites W2171326652 @default.
- W3164560156 cites W2179438025 @default.
- W3164560156 cites W2201735116 @default.
- W3164560156 cites W2226740446 @default.
- W3164560156 cites W2261484780 @default.
- W3164560156 cites W2327368021 @default.
- W3164560156 cites W2333474130 @default.
- W3164560156 cites W2417162942 @default.
- W3164560156 cites W2555607948 @default.
- W3164560156 cites W2597897076 @default.
- W3164560156 cites W2607270046 @default.
- W3164560156 cites W2608029792 @default.
- W3164560156 cites W2621479942 @default.
- W3164560156 cites W2732456683 @default.
- W3164560156 cites W2755867701 @default.
- W3164560156 cites W2769853272 @default.
- W3164560156 cites W2779101301 @default.
- W3164560156 cites W2788944862 @default.
- W3164560156 cites W2794365399 @default.
- W3164560156 cites W2805627351 @default.
- W3164560156 cites W2808928947 @default.
- W3164560156 cites W2884761957 @default.
- W3164560156 cites W2885710012 @default.
- W3164560156 cites W2901454839 @default.
- W3164560156 cites W2956134726 @default.
- W3164560156 cites W2979983023 @default.
- W3164560156 cites W2998137297 @default.
- W3164560156 cites W2999552632 @default.
- W3164560156 cites W3012561843 @default.
- W3164560156 cites W3033018263 @default.
- W3164560156 cites W3081896287 @default.
- W3164560156 cites W57306529 @default.
- W3164560156 cites W858332724 @default.
- W3164560156 doi "https://doi.org/10.1021/acs.chemrestox.0c00333" @default.
- W3164560156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8560124" @default.
- W3164560156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34048650" @default.
- W3164560156 hasPublicationYear "2021" @default.
- W3164560156 type Work @default.
- W3164560156 sameAs 3164560156 @default.
- W3164560156 citedByCount "10" @default.
- W3164560156 countsByYear W31645601562021 @default.
- W3164560156 countsByYear W31645601562022 @default.
- W3164560156 countsByYear W31645601562023 @default.
- W3164560156 crossrefType "journal-article" @default.
- W3164560156 hasAuthorship W3164560156A5074912970 @default.
- W3164560156 hasAuthorship W3164560156A5075469209 @default.
- W3164560156 hasAuthorship W3164560156A5077210745 @default.
- W3164560156 hasBestOaLocation W31645601562 @default.