FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164567320> ?p ?o ?g. }

• W3164567320 endingPage "126792" @default.
• W3164567320 startingPage "126792" @default.
• W3164567320 abstract "Regulatory networks play critical roles in controlling the the biosynthesis of natural products in Streptomyces. ActVI-ORFA, a regulatory factor encoded by the actinorhodin biosynthetic gene cluster (act cluster), positively controls the production of actinorhodin (ACT) in Streptomyces coelicolor, although its regulatory mechanism remains obscure. This study aimed to identify the regulatory targets of ActVI-ORFA. Deletion of ActVI-ORFA caused the differential expression of hundreds of proteins, as determined by two-dimensional electrophoresis and peptide mass fingerprinting analysis. qRT-PCR analysis of some genes encoding these differentially expressed proteins, including act genes and non-act genes, confirmed that ActVI-ORFA could control their transcriptional levels. In an electrophoretic mobility shift assay with a promoter region of a target gene located in the act cluster, no binding was detected, consistent with the lack of a recognizable DNA-binding domain in ActVI-ORFA. Overall, our findings suggest that ActVI-ORFA is a pleiotropic regulatory factor that controls multiple physiological pathways, including secondary metabolite production, probably via an indirect mode." @default.
• W3164567320 created "2021-06-07" @default.
• W3164567320 creator A5001839464 @default.
• W3164567320 creator A5021053144 @default.
• W3164567320 creator A5056021955 @default.
• W3164567320 creator A5075277705 @default.
• W3164567320 date "2021-09-01" @default.
• W3164567320 modified "2023-10-17" @default.
• W3164567320 title "Pleiotropic effects of ActVI-ORFA as an unusual regulatory factor identified in the biosynthetic pathway of actinorhodin in Streptomyces coelicolor" @default.
• W3164567320 cites W1814148485 @default.
• W3164567320 cites W1911399467 @default.
• W3164567320 cites W1989857762 @default.
• W3164567320 cites W2004659858 @default.
• W3164567320 cites W2011881132 @default.
• W3164567320 cites W2012960603 @default.
• W3164567320 cites W2021093204 @default.
• W3164567320 cites W2039947832 @default.
• W3164567320 cites W2041051287 @default.
• W3164567320 cites W2041467484 @default.
• W3164567320 cites W2042358518 @default.
• W3164567320 cites W2077763739 @default.
• W3164567320 cites W2085441805 @default.
• W3164567320 cites W2090988351 @default.
• W3164567320 cites W2095063801 @default.
• W3164567320 cites W2096919138 @default.
• W3164567320 cites W2107277218 @default.
• W3164567320 cites W2137891225 @default.
• W3164567320 cites W2146193735 @default.
• W3164567320 cites W2149220857 @default.
• W3164567320 cites W2417585904 @default.
• W3164567320 cites W2582479444 @default.
• W3164567320 cites W2735242026 @default.
• W3164567320 cites W2765437187 @default.
• W3164567320 cites W2792190845 @default.
• W3164567320 cites W2884990729 @default.
• W3164567320 cites W2893961844 @default.
• W3164567320 cites W2915558519 @default.
• W3164567320 cites W2939524881 @default.
• W3164567320 cites W2958473633 @default.
• W3164567320 cites W2990504175 @default.
• W3164567320 cites W2994759188 @default.
• W3164567320 cites W2999737881 @default.
• W3164567320 cites W3001546882 @default.
• W3164567320 cites W3017733664 @default.
• W3164567320 cites W3046226165 @default.
• W3164567320 cites W3110940241 @default.
• W3164567320 cites W852427928 @default.
• W3164567320 doi "https://doi.org/10.1016/j.micres.2021.126792" @default.
• W3164567320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34082307" @default.
• W3164567320 hasPublicationYear "2021" @default.
• W3164567320 type Work @default.
• W3164567320 sameAs 3164567320 @default.
• W3164567320 citedByCount "0" @default.
• W3164567320 crossrefType "journal-article" @default.
• W3164567320 hasAuthorship W3164567320A5001839464 @default.
• W3164567320 hasAuthorship W3164567320A5021053144 @default.
• W3164567320 hasAuthorship W3164567320A5056021955 @default.
• W3164567320 hasAuthorship W3164567320A5075277705 @default.
• W3164567320 hasConcept C101762097 @default.
• W3164567320 hasConcept C104317684 @default.
• W3164567320 hasConcept C143065580 @default.
• W3164567320 hasConcept C150194340 @default.
• W3164567320 hasConcept C165864922 @default.
• W3164567320 hasConcept C183978625 @default.
• W3164567320 hasConcept C27153228 @default.
• W3164567320 hasConcept C2776668381 @default.
• W3164567320 hasConcept C2779920670 @default.
• W3164567320 hasConcept C2780681812 @default.
• W3164567320 hasConcept C33498276 @default.
• W3164567320 hasConcept C36857842 @default.
• W3164567320 hasConcept C523546767 @default.
• W3164567320 hasConcept C54355233 @default.
• W3164567320 hasConcept C86339819 @default.
• W3164567320 hasConcept C86803240 @default.
• W3164567320 hasConceptScore W3164567320C101762097 @default.
• W3164567320 hasConceptScore W3164567320C104317684 @default.
• W3164567320 hasConceptScore W3164567320C143065580 @default.
• W3164567320 hasConceptScore W3164567320C150194340 @default.
• W3164567320 hasConceptScore W3164567320C165864922 @default.
• W3164567320 hasConceptScore W3164567320C183978625 @default.
• W3164567320 hasConceptScore W3164567320C27153228 @default.
• W3164567320 hasConceptScore W3164567320C2776668381 @default.
• W3164567320 hasConceptScore W3164567320C2779920670 @default.
• W3164567320 hasConceptScore W3164567320C2780681812 @default.
• W3164567320 hasConceptScore W3164567320C33498276 @default.
• W3164567320 hasConceptScore W3164567320C36857842 @default.
• W3164567320 hasConceptScore W3164567320C523546767 @default.
• W3164567320 hasConceptScore W3164567320C54355233 @default.
• W3164567320 hasConceptScore W3164567320C86339819 @default.
• W3164567320 hasConceptScore W3164567320C86803240 @default.
• W3164567320 hasFunder F4320321001 @default.
• W3164567320 hasFunder F4320324174 @default.
• W3164567320 hasFunder F4320327912 @default.
• W3164567320 hasFunder F4320335777 @default.
• W3164567320 hasFunder F4320336026 @default.
• W3164567320 hasLocation W31645673201 @default.
• W3164567320 hasLocation W31645673202 @default.
• W3164567320 hasOpenAccess W3164567320 @default.

• next