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- W3164603583 endingPage "69" @default.
- W3164603583 startingPage "53" @default.
- W3164603583 abstract "The emergence of carbapenemase resistant Gram-negative is designated as an 'urgent' priority of public health. Carbapenemase producing Klebsiella pneumoniae (CPKP) is linked with significant mortality. Conventionally used antibiotics (polymyxins, tigecycline, aminoglycosides, etc.) are associated with poor efficacy and toxicity profiles are quite worrisome.This article reviews mechanism of resistance and evidence regarding novel treatments of infections caused by CPKP, focusing mainly on currently approved new therapies and implications on future therapeutic strategies. A review of novel β-lactam/β-lactamase inhibitors (BLI) recently approved and in clinical development as well as cefiderocol, eravacycline and apramycin are discussed.Newly approved and forthcoming antimicrobial agents are promising to combat infections caused by CPKP. Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-cilastatin-relebactam are novel agents with favorable outcome and associated with improved mortality in KPC-producing K.pneumoniae infections. However, are inactive against metallo-β-lactamases (MBL). Novel BLI in later stage of development, i.e. aztreonam-avibactam, cefepime-zidebactam, cefepime-taniborbactam, and meropenem-nacubactam as well as cefiderocol are active invitro against both KPC and MBL. Potential expectations of future therapeutic strategies are improved potency against CPKP, more tolerable safety profile, and capability of overcoming current resistance mechanism of multidrug-resistant K.pneumoniae." @default.
- W3164603583 created "2021-06-07" @default.
- W3164603583 creator A5005851825 @default.
- W3164603583 creator A5045620840 @default.
- W3164603583 creator A5052146006 @default.
- W3164603583 creator A5071394239 @default.
- W3164603583 creator A5072775316 @default.
- W3164603583 date "2021-06-03" @default.
- W3164603583 modified "2023-09-30" @default.
- W3164603583 title "Carbapenemase producing <i>Klebsiella pneumoniae</i>: implication on future therapeutic strategies" @default.
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