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- W3164610320 abstract "Thousands of species will be sequenced in the next few years; however, understanding how their genomes work, without an unlimited budget, requires both molecular and novel evolutionary approaches. We developed a sensitive sequence alignment pipeline to identify conserved noncoding sequences (CNSs) in the Andropogoneae tribe (multiple crop species descended from a common ancestor ∼18 million years ago). The Andropogoneae share similar physiology while being tremendously genomically diverse, harboring a broad range of ploidy levels, structural variation, and transposons. These contribute to the potential of Andropogoneae as a powerful system for studying CNSs and are factors we leverage to understand the function of maize CNSs. We found that 86% of CNSs were comprised of annotated features, including introns, UTRs, putative cis-regulatory elements, chromatin loop anchors, noncoding RNA (ncRNA) genes, and several transposable element superfamilies. CNSs were enriched in active regions of DNA replication in the early S phase of the mitotic cell cycle and showed different DNA methylation ratios compared to the genome-wide background. More than half of putative cis-regulatory sequences (identified via other methods) overlapped with CNSs detected in this study. Variants in CNSs were associated with gene expression levels, and CNS absence contributed to loss of gene expression. Furthermore, the evolution of CNSs was associated with the functional diversification of duplicated genes in the context of maize subgenomes. Our results provide a quantitative understanding of the molecular processes governing the evolution of CNSs in maize." @default.
- W3164610320 created "2021-06-07" @default.
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- W3164610320 date "2021-05-27" @default.
- W3164610320 modified "2023-10-13" @default.
- W3164610320 title "Conserved noncoding sequences provide insights into regulatory sequence and loss of gene expression in maize" @default.
- W3164610320 cites W1594737021 @default.
- W3164610320 cites W1844405070 @default.
- W3164610320 cites W1865845132 @default.
- W3164610320 cites W1884519301 @default.
- W3164610320 cites W1952527981 @default.
- W3164610320 cites W1965359527 @default.
- W3164610320 cites W1970213292 @default.
- W3164610320 cites W1982855075 @default.
- W3164610320 cites W1988832105 @default.
- W3164610320 cites W2001554877 @default.
- W3164610320 cites W2021779654 @default.
- W3164610320 cites W2034638165 @default.
- W3164610320 cites W2040351382 @default.
- W3164610320 cites W2041471326 @default.
- W3164610320 cites W2048568138 @default.
- W3164610320 cites W2054430532 @default.
- W3164610320 cites W2056573937 @default.
- W3164610320 cites W2058659458 @default.
- W3164610320 cites W2059979506 @default.
- W3164610320 cites W2060141463 @default.
- W3164610320 cites W2062521673 @default.
- W3164610320 cites W2065735621 @default.
- W3164610320 cites W2067634013 @default.
- W3164610320 cites W2072636428 @default.
- W3164610320 cites W2074981513 @default.
- W3164610320 cites W2076658876 @default.
- W3164610320 cites W2087064593 @default.
- W3164610320 cites W2093931624 @default.
- W3164610320 cites W2094519647 @default.
- W3164610320 cites W2095955242 @default.
- W3164610320 cites W2098773881 @default.
- W3164610320 cites W2100267912 @default.
- W3164610320 cites W2101071606 @default.
- W3164610320 cites W2101383499 @default.
- W3164610320 cites W2103441770 @default.
- W3164610320 cites W2103914320 @default.
- W3164610320 cites W2105214361 @default.
- W3164610320 cites W2106597634 @default.
- W3164610320 cites W2107337799 @default.
- W3164610320 cites W2108234281 @default.
- W3164610320 cites W2110284618 @default.
- W3164610320 cites W2113458225 @default.
- W3164610320 cites W2114970231 @default.
- W3164610320 cites W2116464462 @default.
- W3164610320 cites W2119180969 @default.
- W3164610320 cites W2122429294 @default.
- W3164610320 cites W2123921145 @default.
- W3164610320 cites W2128489434 @default.
- W3164610320 cites W2130925862 @default.
- W3164610320 cites W2132799322 @default.
- W3164610320 cites W2134112768 @default.
- W3164610320 cites W2142486812 @default.
- W3164610320 cites W2143172590 @default.
- W3164610320 cites W2147848023 @default.
- W3164610320 cites W2150654633 @default.
- W3164610320 cites W2154166873 @default.
- W3164610320 cites W2155628349 @default.
- W3164610320 cites W2156673173 @default.
- W3164610320 cites W2234533219 @default.
- W3164610320 cites W2259938310 @default.
- W3164610320 cites W2401562190 @default.
- W3164610320 cites W2405567513 @default.
- W3164610320 cites W2409781001 @default.
- W3164610320 cites W2410745085 @default.
- W3164610320 cites W2515922456 @default.
- W3164610320 cites W2560119881 @default.
- W3164610320 cites W2575750030 @default.
- W3164610320 cites W2594730553 @default.
- W3164610320 cites W2599581093 @default.
- W3164610320 cites W2611102567 @default.
- W3164610320 cites W2623168030 @default.
- W3164610320 cites W2624089641 @default.
- W3164610320 cites W2737056215 @default.
- W3164610320 cites W2747655851 @default.
- W3164610320 cites W2749628345 @default.
- W3164610320 cites W2765098025 @default.
- W3164610320 cites W2767310027 @default.
- W3164610320 cites W2770852695 @default.
- W3164610320 cites W2774072836 @default.
- W3164610320 cites W2788228074 @default.
- W3164610320 cites W2788268580 @default.