FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164628057> ?p ?o ?g. }

• W3164628057 abstract "Abstract Background Multiple organ dysfunction syndrome is the leading cause of death in pediatric intensive care units and can be very critical when combined with shock and disseminated intravascular coagulation (DIC). Currently, there is no effective treatment. We developed a new hemodiafiltration (HDF) method called plasma HDF (PHDF) that uses fresh frozen plasma as replacement fluid and investigated the safety and efficacy of this treatment. Methods We enrolled critically ill children with (1) a Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score ≥ 14, (2) a Japanese Ministry of Health and Welfare (JMHW) DIC score ≥ 7, (3) a vasoactive inotropic score (VIS) ≥ 10, and (4) a serum total protein concentration ≤ 5.0 g/dL. PHDF was performed for 5 h and then switched to continuous HDF. The primary endpoint was the 28-day mortality rate. Secondary endpoints included assessment of vital signs, blood test data, and fluid balance from PHDF start to day 7. Results Nine patients (four males and five females) between 3 days and 40 months of age, weighing 2.1–13 kg, met the inclusion criteria. Although the median PMR was 0.94 (0.71–0.96), the 28-day mortality rate was 22.2% (2/9). One hour after the start of PHDF, there was an increase in mean arterial pressure and central venous pressure and a decrease in heart rate; by day 7, there was a significant decrease in the PELOD-2 score, the JMHW DIC score, and the VIS. Hypoproteinemia also improved the day after PHDF. Water balance was able to remain negative after day 2. Conclusions PHDF was found to be effective in the treatment of DIC and circulatory failure by supplementing coagulation and antithrombotic factors as well as by raising colloid osmotic pressure to increase circulating blood volume. PHDF has been shown to be a safe and useful treatment for critically ill children and has the potential to improve 28-day survival." @default.
• W3164628057 created "2021-06-07" @default.
• W3164628057 creator A5028090784 @default.
• W3164628057 creator A5031183549 @default.
• W3164628057 creator A5064085530 @default.
• W3164628057 creator A5078099306 @default.
• W3164628057 creator A5079255032 @default.
• W3164628057 date "2021-04-07" @default.
• W3164628057 modified "2023-10-17" @default.
• W3164628057 title "Efficacy and safety of plasma hemodiafiltration (PHDF) in pediatric patients with multiple organ dysfunction syndrome with shock and DIC: a preliminary study" @default.
• W3164628057 cites W18152198 @default.
• W3164628057 cites W1963826623 @default.
• W3164628057 cites W1967499351 @default.
• W3164628057 cites W1968003238 @default.
• W3164628057 cites W1975198268 @default.
• W3164628057 cites W1979650759 @default.
• W3164628057 cites W1995457200 @default.
• W3164628057 cites W1999829047 @default.
• W3164628057 cites W2002926363 @default.
• W3164628057 cites W2022938424 @default.
• W3164628057 cites W2042741544 @default.
• W3164628057 cites W2075859866 @default.
• W3164628057 cites W2081598833 @default.
• W3164628057 cites W2087942074 @default.
• W3164628057 cites W2092623210 @default.
• W3164628057 cites W2103008130 @default.
• W3164628057 cites W2127258061 @default.
• W3164628057 cites W2170963650 @default.
• W3164628057 cites W2321829810 @default.
• W3164628057 cites W2331697328 @default.
• W3164628057 cites W2592778288 @default.
• W3164628057 cites W2619168870 @default.
• W3164628057 cites W2784785350 @default.
• W3164628057 cites W2792217843 @default.
• W3164628057 cites W2902614592 @default.
• W3164628057 doi "https://doi.org/10.1186/s41100-021-00335-x" @default.
• W3164628057 hasPublicationYear "2021" @default.
• W3164628057 type Work @default.
• W3164628057 sameAs 3164628057 @default.
• W3164628057 citedByCount "0" @default.
• W3164628057 crossrefType "journal-article" @default.
• W3164628057 hasAuthorship W3164628057A5028090784 @default.
• W3164628057 hasAuthorship W3164628057A5031183549 @default.
• W3164628057 hasAuthorship W3164628057A5064085530 @default.
• W3164628057 hasAuthorship W3164628057A5078099306 @default.
• W3164628057 hasAuthorship W3164628057A5079255032 @default.
• W3164628057 hasBestOaLocation W31646280571 @default.
• W3164628057 hasConcept C126322002 @default.
• W3164628057 hasConcept C141071460 @default.
• W3164628057 hasConcept C168563851 @default.
• W3164628057 hasConcept C179755657 @default.
• W3164628057 hasConcept C203092338 @default.
• W3164628057 hasConcept C2777140744 @default.
• W3164628057 hasConcept C2777953023 @default.
• W3164628057 hasConcept C2778384902 @default.
• W3164628057 hasConcept C2778426790 @default.
• W3164628057 hasConcept C2778734968 @default.
• W3164628057 hasConcept C2779936836 @default.
• W3164628057 hasConcept C2780835948 @default.
• W3164628057 hasConcept C2781300812 @default.
• W3164628057 hasConcept C35207712 @default.
• W3164628057 hasConcept C42219234 @default.
• W3164628057 hasConcept C66112548 @default.
• W3164628057 hasConcept C71924100 @default.
• W3164628057 hasConcept C84393581 @default.
• W3164628057 hasConcept C89560881 @default.
• W3164628057 hasConceptScore W3164628057C126322002 @default.
• W3164628057 hasConceptScore W3164628057C141071460 @default.
• W3164628057 hasConceptScore W3164628057C168563851 @default.
• W3164628057 hasConceptScore W3164628057C179755657 @default.
• W3164628057 hasConceptScore W3164628057C203092338 @default.
• W3164628057 hasConceptScore W3164628057C2777140744 @default.
• W3164628057 hasConceptScore W3164628057C2777953023 @default.
• W3164628057 hasConceptScore W3164628057C2778384902 @default.
• W3164628057 hasConceptScore W3164628057C2778426790 @default.
• W3164628057 hasConceptScore W3164628057C2778734968 @default.
• W3164628057 hasConceptScore W3164628057C2779936836 @default.
• W3164628057 hasConceptScore W3164628057C2780835948 @default.
• W3164628057 hasConceptScore W3164628057C2781300812 @default.
• W3164628057 hasConceptScore W3164628057C35207712 @default.
• W3164628057 hasConceptScore W3164628057C42219234 @default.
• W3164628057 hasConceptScore W3164628057C66112548 @default.
• W3164628057 hasConceptScore W3164628057C71924100 @default.
• W3164628057 hasConceptScore W3164628057C84393581 @default.
• W3164628057 hasConceptScore W3164628057C89560881 @default.
• W3164628057 hasLocation W31646280571 @default.
• W3164628057 hasOpenAccess W3164628057 @default.
• W3164628057 hasPrimaryLocation W31646280571 @default.
• W3164628057 hasRelatedWork W10623557 @default.
• W3164628057 hasRelatedWork W10698368 @default.
• W3164628057 hasRelatedWork W12234050 @default.
• W3164628057 hasRelatedWork W12451132 @default.
• W3164628057 hasRelatedWork W14992206 @default.
• W3164628057 hasRelatedWork W18152198 @default.
• W3164628057 hasRelatedWork W3304483 @default.
• W3164628057 hasRelatedWork W62318 @default.
• W3164628057 hasRelatedWork W7391891 @default.
• W3164628057 hasRelatedWork W9837179 @default.
• W3164628057 isParatext "false" @default.
• W3164628057 isRetracted "false" @default.

• next