Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164630907> ?p ?o ?g. }
- W3164630907 abstract "Abstract O‐GlcNAcylation is a ubiquitous post‐translational modification that is extremely labile and plays a significant role in physiology, including the heart. Sustained activation of cardiac O‐GlcNAcylation is frequently associated with alterations in cellular metabolism, leading to detrimental effects on cardiovascular function. This is particularly true during conditions such as diabetes, hypertension, cardiac remodelling, heart failure and arrhythmogenesis. Paradoxically, transient elevation of cardiac protein O‐GlcNAcylation can also exert beneficial effects in the heart. There is compelling evidence to suggest that a complex interaction between O‐GlcNAcylation and phosphorylation also exists in the heart. Beyond direct functional consequences on cardiomyocytes, O‐GlcNAcylation also acts indirectly by altering the function of transcription factors that affect downstream signalling. This review focuses on the potential cardioprotective role of protein O‐GlcNAcylation during ischaemia‐reperfusion injury, the deleterious consequences of chronically elevated O‐GlcNAc levels, the interplay between O‐GlcNAcylation and phosphorylation in the cardiomyocytes and the effects of O‐GlcNAcylation on other major non‐myocyte cell types in the heart." @default.
- W3164630907 created "2021-06-07" @default.
- W3164630907 creator A5007560905 @default.
- W3164630907 creator A5009100296 @default.
- W3164630907 creator A5064601457 @default.
- W3164630907 creator A5070180043 @default.
- W3164630907 creator A5091764181 @default.
- W3164630907 date "2021-06-17" @default.
- W3164630907 modified "2023-10-16" @default.
- W3164630907 title "Protein O‐GlcNAcylation in the heart" @default.
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