FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164642214> ?p ?o ?g. }

• W3164642214 endingPage "972" @default.
• W3164642214 startingPage "963" @default.
• W3164642214 abstract "PD-1/PD-L1 blocking therapy has become one of the most promising methods in the field of tumor treatment. However, it encounters the challenge of immune escape due to the exhaustion of T cells. Studies have shown that the epigenetic regulation drug histone deacetylase inhibitor (HDACi) may be able to reverse exhausted T cells by changing the epigenetic transcription program. Therefore, the combination of epigenetic therapy and PD-1/PD-L1 blockade therapy is expected to reverse the immune escape, whereas the overriding goal should aim at the spontaneous release and synergy of PD-1/PD-L1 blocking siRNA and HDACi. In this study, we develop PDDS{polyethylene glycol-b-asparaginate(diethylenetriamine-vorinostat), (PEG-b-P[Asp(DET-SAHA)n] PPDS)}encapsulating siRNA-PD-L1to provide micelles siRNA-PD-L1-loaded micelles (siRNA@PPDS). Transmission electron microscope (TEM) images demonstrate that siRNA@PPDS micelles presented spherical morphology with a size of about 120 nm; hydrodynamic data analysis indicates pH sensitivity of siRNA@PPDS micelles. The experiments reveal that siRNA@PPDS micelles could be well uptaken by the tumor cells to silence the expression of PD-L1 protein in a dose-dependent manner; compared with the free SAHA, the SAHA-loaded micelles PPDS show higher cytotoxicity to induce tumor cell apoptosis and block cell cycle in G1 phase on melanoma-bearing mice, siRNA@PPDS has shown outstanding inhibition of tumor growth and pulmonary metastasis. By comprehensively activating the immune system, lysosome activable polymeric vorinostat encapsulating PD-L1KD for the combination therapy of PD-L1-KD and HDACIs can be an effective strategy to reverse the unresponsiveness of immune checkpoint inhibitors and a promising treatment to inhibit tumor growth, recurrence, and metastasis in clinic." @default.
• W3164642214 created "2021-06-07" @default.
• W3164642214 creator A5012443625 @default.
• W3164642214 creator A5013038112 @default.
• W3164642214 creator A5013719639 @default.
• W3164642214 creator A5023558826 @default.
• W3164642214 creator A5025089090 @default.
• W3164642214 creator A5046152184 @default.
• W3164642214 creator A5061908974 @default.
• W3164642214 creator A5068669762 @default.
• W3164642214 creator A5069265733 @default.
• W3164642214 date "2021-01-01" @default.
• W3164642214 modified "2023-10-03" @default.
• W3164642214 title "Lysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy" @default.
• W3164642214 cites W1481633630 @default.
• W3164642214 cites W1498454097 @default.
• W3164642214 cites W1985182657 @default.
• W3164642214 cites W1998458019 @default.
• W3164642214 cites W2001737550 @default.
• W3164642214 cites W2004630197 @default.
• W3164642214 cites W2019173523 @default.
• W3164642214 cites W2033577259 @default.
• W3164642214 cites W2051455650 @default.
• W3164642214 cites W2051830227 @default.
• W3164642214 cites W2068116723 @default.
• W3164642214 cites W2089618836 @default.
• W3164642214 cites W2098005365 @default.
• W3164642214 cites W2103665811 @default.
• W3164642214 cites W2122605363 @default.
• W3164642214 cites W2156440836 @default.
• W3164642214 cites W2165263439 @default.
• W3164642214 cites W2174136617 @default.
• W3164642214 cites W2177971463 @default.
• W3164642214 cites W2301488980 @default.
• W3164642214 cites W2323330456 @default.
• W3164642214 cites W2334650916 @default.
• W3164642214 cites W2338494814 @default.
• W3164642214 cites W2497442705 @default.
• W3164642214 cites W2506616866 @default.
• W3164642214 cites W2541574334 @default.
• W3164642214 cites W2548210940 @default.
• W3164642214 cites W2591189187 @default.
• W3164642214 cites W2606494852 @default.
• W3164642214 cites W2608694312 @default.
• W3164642214 cites W2610082331 @default.
• W3164642214 cites W2617088135 @default.
• W3164642214 cites W2738363017 @default.
• W3164642214 cites W2746334444 @default.
• W3164642214 cites W2756422634 @default.
• W3164642214 cites W2771850922 @default.
• W3164642214 cites W2889763022 @default.
• W3164642214 cites W2913630332 @default.
• W3164642214 cites W2918948206 @default.
• W3164642214 cites W2966507386 @default.
• W3164642214 cites W3088547513 @default.
• W3164642214 cites W3096710313 @default.
• W3164642214 cites W3126492050 @default.
• W3164642214 doi "https://doi.org/10.1080/10717544.2021.1927246" @default.
• W3164642214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8158275" @default.
• W3164642214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34036867" @default.
• W3164642214 hasPublicationYear "2021" @default.
• W3164642214 type Work @default.
• W3164642214 sameAs 3164642214 @default.
• W3164642214 citedByCount "8" @default.
• W3164642214 countsByYear W31646422142021 @default.
• W3164642214 countsByYear W31646422142022 @default.
• W3164642214 countsByYear W31646422142023 @default.
• W3164642214 crossrefType "journal-article" @default.
• W3164642214 hasAuthorship W3164642214A5012443625 @default.
• W3164642214 hasAuthorship W3164642214A5013038112 @default.
• W3164642214 hasAuthorship W3164642214A5013719639 @default.
• W3164642214 hasAuthorship W3164642214A5023558826 @default.
• W3164642214 hasAuthorship W3164642214A5025089090 @default.
• W3164642214 hasAuthorship W3164642214A5046152184 @default.
• W3164642214 hasAuthorship W3164642214A5061908974 @default.
• W3164642214 hasAuthorship W3164642214A5068669762 @default.
• W3164642214 hasAuthorship W3164642214A5069265733 @default.
• W3164642214 hasBestOaLocation W31646422141 @default.
• W3164642214 hasConcept C104317684 @default.
• W3164642214 hasConcept C11268172 @default.
• W3164642214 hasConcept C147789679 @default.
• W3164642214 hasConcept C184651966 @default.
• W3164642214 hasConcept C185592680 @default.
• W3164642214 hasConcept C192562407 @default.
• W3164642214 hasConcept C203014093 @default.
• W3164642214 hasConcept C2776202225 @default.
• W3164642214 hasConcept C2776262904 @default.
• W3164642214 hasConcept C2778305200 @default.
• W3164642214 hasConcept C502942594 @default.
• W3164642214 hasConcept C55493867 @default.
• W3164642214 hasConcept C64927066 @default.
• W3164642214 hasConcept C71924100 @default.
• W3164642214 hasConcept C8891405 @default.
• W3164642214 hasConcept C98274493 @default.
• W3164642214 hasConceptScore W3164642214C104317684 @default.
• W3164642214 hasConceptScore W3164642214C11268172 @default.
• W3164642214 hasConceptScore W3164642214C147789679 @default.
• W3164642214 hasConceptScore W3164642214C184651966 @default.

• next